Abstract：
BACKGROUND/OBJECTIVE:Many studies have shown a U-shaped association of sleep duration with mortality; however, this association is difficult to interpret owing to possible reverse causation, residual confounding, and measurement issues. We used data from the Women's Health Initiative to examine the associations of sleep duration, insomnia, and use of sleep aids with death from cardiovascular disease (CVD), cancer, "other" causes, and all causes combined. METHODS:Cox proportional hazards models were used in the analysis of baseline data and in time-dependent analyses of repeated measures to estimate associations of sleep-related factors with mortality. Among 158,203 women with information regarding sleep, 30,400 total deaths, 8857 CVD deaths, 9284 cancer deaths, and 11,928 other deaths were ascertained over a median of 17.8 years. RESULTS:In both baseline and time-dependent analyses, both short (≤5 h) and long sleep (≥9 h) durations were associated with increased risk of total, CVD, and "other" deaths, but not with cancer deaths. Insomnia showed no association with mortality, whereas use of sleep medications was associated with an increased mortality risk. CONCLUSIONS:While our findings showed a small but robust association of sleep duration with mortality in postmenopausal women, studies including objective measurements of sleep quality and efficiency are needed to clarify these associations.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Kabat GC,Xue X,Kamensky V,Zaslavsky O,Stone KL,Johnson KC,Wassertheil-Smoller S,Shadyab AH,Luo J,Hale L,Qi L,Cauley JA,Brunner RL,Manson JE,Rohan TEdoi
10.1016/j.sleep.2018.05.015subject
Has Abstractpub_date
2018-10-01 00:00:00pages
48-54eissn
1389-9457issn
1878-5506pii
S1389-9457(18)30202-8journal_volume
50pub_type
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