当前位置： SCI文献检索 > SLEEP MEDICINE期刊下所有文献 > Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP.

Effects of modafinil on sustained attention performance and quality of life in OSA patients with residual sleepiness while being treated with nCPAP.

Abstract：

BACKGROUND:Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) who are regular users of nasal continuous positive airway pressure (nCPAP) therapy continue to experience daytime sleepiness that impairs performance and quality of life. A randomized, double-blind, placebo-controlled, parallel-group study was conducted to determine the effect of modafinil on sustained attention performance and functional quality of life in OSA/HS patients with residual daytime sleepiness, who were regular users of nCPAP therapy. METHODS:Seventy-seven patients received modafinil (200 mg/day, week 1; 400 mg/day, weeks 2-4) and 80 patients received matching placebo once daily for 4 weeks. Sustained attention performance on the psychomotor vigilance task (PVT) and functional status and quality of life using the Functional Outcomes of Sleep Questionnaire (FOSQ) were measured. RESULTS:The frequency of lapses of attention during PVT performance was significantly decreased, and both the median and slowest reaction times were significantly improved in patients receiving nCPAP plus modafinil compared with those receiving nCPAP plus placebo (P=0.010 for the number of lapses [transformed], P=0.023 for the median reaction time, and P=0.014 for the reciprocal of the 10% slowest reaction times). Treatment with nCPAP plus modafinil significantly improved the FOSQ total score (weeks 1 and 4), the vigilance subscale score (weeks 1 and 4), and the activity level subscale score (week 4) compared with treatment with nCPAP plus placebo (all P<0.05). CONCLUSIONS:Consistent with previous results for objective and subjective measures of sleepiness, modafinil used adjunctively improved performance on a test of behavioral alertness and reduced functional impairments in patients with OSA/HS who were regular users of nCPAP therapy but still experiencing sleepiness.

journal_name

Sleep Med

journal_title

Sleep medicine

authors

Dinges DF,Weaver TE

doi

10.1016/s1389-9457(03)00108-4

keywords:

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

393-402

issue

5

eissn

1389-9457

issn

1878-5506

pii

S1389945703001084

journal_volume

4

pub_type

临床试验,杂志文章,随机对照试验

相关文献

SLEEP MEDICINE文献大全
  • Modulation of upper and lower esophageal sphincter tone during sleep.

    abstract：BACKGROUND AND PURPOSE:The pressures generated within the upper esophageal sphincter (P(UES)) and lower esophageal sphincter (P(LES)) reflect the integrity of these barriers to gastroesophageal and pharyngoesophageal reflux, respectively. This study sought to describe the effects of sleep, respiration and posture on th...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2006.08.016

    authors： Eastwood PR,Katagiri S,Shepherd KL,Hillman DR

    更新日期：2007-03-01 00:00:00

  • Contextualised urinary biomarker analysis facilitates diagnosis of paediatric obstructive sleep apnoea.

    abstract：BACKGROUND:Intrinsic variance of the urine proteome limits the discriminative power of proteomic analysis and complicates potential biomarker detection in the context of paediatric sleep disorders. METHODS AND RESULTS:Using a rigorous workflow for proteomic analysis of urine, we demonstrate that gender and diurnal eff...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2014.01.010

    authors： Becker L,Kheirandish-Gozal L,Peris E,Schoenfelt KQ,Gozal D

    更新日期：2014-05-01 00:00:00

  • Sensitivity and specificity of Frontal Assessment Battery in newly diagnosed and untreated obstructive sleep apnea patients.

    abstract：BACKGROUND:Executive dysfunction (ED) is often observed in subjects diagnosed with obstructive sleep apnea (OSA), but their assessment requires facilities that are not always available. We aim to evaluate the extent to which Frontal Assessment Battery (FAB) discriminates ED in newly diagnosed, untreated, and without-co...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2017.11.1122

    authors： Ladera V,Sargento P,Perea V,Faria M,Garcia R

    更新日期：2018-02-01 00:00:00

  • Test-to-test variability in motor activity during the suggested immobilization test in restless legs patients.

    abstract：BACKGROUND AND PURPOSE:To evaluate the test-to-test variability of the suggested immobilization test (SIT) in patients with restless legs syndrome (RLS). PATIENTS AND METHODS:Twenty patients with primary RLS (12 men and eight women; age: 53.3+/-11.3 years) were selected for the study. We compared the results of two SI...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2006.02.007

    authors： Haba-Rubio J,Sforza E

    更新日期：2006-10-01 00:00:00

  • Atomoxetine improves sleepiness and global severity of illness but not the respiratory disturbance index in mild to moderate obstructive sleep apnea with sleepiness.

    abstract：BACKGROUND AND PURPOSE:Norepinephrine reuptake inhibitors such as protriptyline have been shown to improve sleepiness in sleep apnea, with or without improvement in the respiratory disturbance index (RDI). This study was performed to evaluate whether the selective norepinephrine reuptake inhibitor atomoxetine improves ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2007.07.013

    authors： Bart Sangal R,Sangal JM,Thorp K

    更新日期：2008-07-01 00:00:00

  • Unaltered EEG spectral power and functional connectivity in REM microstates in frequent nightmare recallers: are nightmares really a REM parasomnia?

    abstract：BACKGROUND:Frequent nightmares show signs of hyperarousal in NREM sleep. Nevertheless, idiopathic nightmare disorder is considered a REM parasomnia, but the pathophysiology of REM sleep in relation to frequent nightmares is controversial. Cortical oscillatory activity in REM sleep is largely modulated by phasic and ton...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2020.07.014

    authors： van der Wijk G,Blaskovich B,Farahzadi Y,Simor P

    更新日期：2020-11-01 00:00:00

  • EEG topography during sleep inertia upon awakening after a period of increased homeostatic sleep pressure.

    abstract：OBJECTIVE:Behavioral and physiological indexes of high sleep inertia (SI) characterize the awakening from recovery (REC) sleep after prolonged wakefulness, but the associated electroencephalogram (EEG) topography has never been investigated. Here, we compare the EEG topography following the awakening from baseline (BSL...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2015.03.009

    authors： Gorgoni M,Ferrara M,D'Atri A,Lauri G,Scarpelli S,Truglia I,De Gennaro L

    更新日期：2015-07-01 00:00:00

  • Sleep architecture and attenuated heart rate response to arousal from sleep in patients with autonomic failure.

    abstract：OBJECTIVE:To determine if patients with autonomic failure have increased sleep disturbances and if multiple system atrophy (MSA) and pure autonomic failure (PAF) patients have frequent arousals from sleep associated with an attenuated heart rate (HR) response compared to healthy volunteers. METHODS:With informed conse...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2008.12.017

    authors： Freilich S,Goff EA,Malaweera AS,Twigg GL,Simonds AK,Mathias CJ,Morrell MJ

    更新日期：2010-01-01 00:00:00

  • Emergence of restless legs syndrome after subthalamic stimulation in Parkinson's disease: a dopaminergic overstimulation?

    abstract：OBJECTIVE:Studies investigating the effects of subthalamic deep-brain stimulation (DBS-STN) on restless legs syndrome (RLS) in Parkinson's disease (PD) are limited and report conflicting results, with some describing the emergence of RLS after DBS-STN, while others report postoperative improvement of this disorder. Sev...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2014.11.020

    authors： Marques A,Fantini ML,Morand D,Pereira B,Derost P,Ulla M,Debilly B,Lemaire JJ,Durif F

    更新日期：2015-05-01 00:00:00

  • Sleep perception in insomniacs, sleep-disordered breathing patients, and healthy volunteers--an important biologic parameter of sleep.

    abstract：BACKGROUND:The mechanisms involved in sleep perception are not widely known. Therefore, we believe that investigating this phenomenon is the best way to understand some of the mechanisms involved in several sleep disturbances, particularly insomnias. OBJECTIVE:The objective of our study was to evaluate sleep perceptio...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2008.06.016

    authors： Pinto LR Jr,Pinto MC,Goulart LI,Truksinas E,Rossi MV,Morin CM,Tufik S

    更新日期：2009-09-01 00:00:00

  • Increased severity of sleep-disordered breathing is associated with insomnia and excessive somnolence in primary school children.

    abstract：OBJECTIVE:The aim of the study was to investigate the prevalence of difficulty with initiation or maintenance of sleep (DIMS) and excessive daytime sleepiness (EDS) in a general pediatric population, and to evaluate the relationship between these conditions and sleep-disordered breathing (SDB) symptom intensity. METHO...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2016.04.007

    authors： Kukwa W,Migacz E,Ishman S,Wichniak A

    更新日期：2016-07-01 00:00:00

  • Sleep difficulties one year following mild traumatic brain injury in a population-based study.

    abstract：BACKGROUND:Sleep quality affects all aspects of daily functioning, and it is vital for facilitating recovery from illness and injury. Sleep commonly becomes disrupted following moderate to severe brain injury, yet little is known about the prevalence of sleep disruption over time and how it impacts on recovery followin...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2015.04.013

    authors： Theadom A,Cropley M,Parmar P,Barker-Collo S,Starkey N,Jones K,Feigin VL,BIONIC Research Group.

    更新日期：2015-08-01 00:00:00

  • Functional neuroimaging studies in restless legs syndrome.

    abstract：:Functional neuroimaging studies may contribute to elucidate pathophysiological mechanisms of the restless legs syndrome (RLS) which still remain unclear. Studies in patients with RLS have been performed using functional magnetic resonance imaging (fMRI), single photon emission computed tomography (SPECT) and, more rec...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2004.01.009

    authors： Wetter TC,Eisensehr I,Trenkwalder C

    更新日期：2004-07-01 00:00:00

  • Obstructive lingual thyroid causing sleep apnea: a case report and review of the literature.

    abstract：:Lingual thyroid has been reported to cause obstructive sleep apnea (OSA) only once in the literature. We present a case of a 49-year-old nonobese female with a 2-year history of progressive snoring, apneas, snort arousals, and daytime somnolence associated with the sensation of an 'enlarging tongue'. She was found to ...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2004.06.005

    authors： Barnes TW,Olsen KD,Morgenthaler TI

    更新日期：2004-11-01 00:00:00

  • Impact of obstructive sleep apnea on silent cerebral small vessel disease: a systematic review and meta-analysis.

    abstract：BACKGROUND:Cerebral small vessel disease (CSVD) is a well-known cause of vascular dementia, a leading medical morbidity in the aging population. Obstructive sleep apnea (OSA) has been validated as a cardiovascular risk factor. However, the relationship between these two clinical syndromes is not well established. We ai...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2019.11.1262

    authors： Chokesuwattanaskul A,Lertjitbanjong P,Thongprayoon C,Bathini T,Sharma K,Mao MA,Cheungpasitporn W,Chokesuwattanaskul R

    更新日期：2020-04-01 00:00:00

  • Sleep complaints: snoring and daytime sleepiness in pregnant and pre-eclamptic women.

    abstract：BACKGROUND AND PURPOSE:To examine whether snoring and sleepiness are linked in pregnancy and pre-eclampsia. PATIENTS AND METHODS:We recruited 167 healthy and 82 pre-eclamptic women in the third trimester of pregnancy and 160 non-pregnant women. Subjects and their partners completed a sleep questionnaire. Height, weigh...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2004.12.007

    authors： Izci B,Martin SE,Dundas KC,Liston WA,Calder AA,Douglas NJ

    更新日期：2005-03-01 00:00:00

  • Cholinergic neurotransmission and olfactory function in obstructive sleep apnea syndrome: a TMS study.

    abstract：BACKGROUND/OBJECTIVE:Odor identification and discrimination are reduced in subjects with obstructive sleep apnea syndrome (OSAS), but the pathophysiology of the olfactory dysfunction in OSAS is still poorly understood. Experimental evidence suggests that olfactory impairment could be related to central cholinergic dysf...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2017.06.021

    authors： Versace V,Langthaler PB,Sebastianelli L,Golaszewski S,Kunz AB,Brigo F,Saltuari L,Nardone R

    更新日期：2017-09-01 00:00:00

  • Association of sleep habits with behavior problems and resilience of 6- to 7-year-old children: results from the A-CHILD study.

    abstract：BACKGROUND:Childhood sleep habits are associated with mental health development; however, little is known about the impact of irregular bedtimes on the mental health of early school-aged children. The aims of this study were to examine the effect of weekday sleep habits (varying bedtimes depending on the night of the w...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2017.12.015

    authors： Doi S,Fujiwara T,Ochi M,Isumi A,Kato T

    更新日期：2018-05-01 00:00:00

  • Sleep habits, circadian preference, and school performance in early adolescents.

    abstract：OBJECTIVE:This study aimed to cast light on the relationships between sleep habits, perceived sleep problems and school performance in Evening-type (E-type) compared with Morning-type (M-type) early adolescents. METHODS:Comparison of questionnaire data of E-type and M-type adolescents random-selected from a large samp...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2016.09.019

    authors： Russo PM,Biasi V,Cipolli C,Mallia L,Caponera E

    更新日期：2017-01-01 00:00:00

  • Nightmare sufferers show atypical emotional semantic associations and prolonged REM sleep-dependent emotional priming.

    abstract：STUDY OBJECTIVES:The objective of this study was to investigate whether nightmare (NM) sufferers exhibit an abnormal network of emotional semantic associations as measured by a recently developed, rapid eye movement (REM) sleep-sensitive, associational breadth (AB) task. DESIGN:NM sufferers were compared to healthy co...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2015.11.013

    authors： Carr M,Blanchette-Carrière C,Marquis LP,Ting CT,Nielsen T

    更新日期：2016-04-01 00:00:00

  • Associations between specific technologies and adolescent sleep quantity, sleep quality, and parasomnias.

    abstract：OBJECTIVE:We tested the hypothesis that weekday bedtime use of six technologies would be significantly associated with eight sleep parameters studied relating to sleep quantity, sleep quality, and parasomnias. METHODS:In our cross-sectional study, we previously administered validated age-appropriate questionnaires (Sc...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2013.08.799

    authors： Arora T,Broglia E,Thomas GN,Taheri S

    更新日期：2014-02-01 00:00:00

  • The influence of sleep disordered breathing in REM sleep behavior disorder.

    abstract：OBJECTIVES/BACKGROUND:Because both REM sleep behavior disorder (RBD) and Obstructive Sleep Apnea (OSA) can present with similar symptoms, it is important to understand the influence of OSA in the clinical manifestations of RBD and whether RBD modulates OSA severity. Our objectives were to compare: 1. the intensity of n...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2017.05.012

    authors： Bugalho P,Mendonça M,Barbosa R,Salavisa M

    更新日期：2017-09-01 00:00:00

  • Rapid eye movement sleep behavior disorder in adults younger than 50 years of age.

    abstract：:Rapid eye movement (REM) sleep behavior disorder (RBD) occurring prior to age 50 is termed early-onset RBD. Early-onset RBD comprises a substantial minority of cases, and demonstrates the differences in demographics, comorbidities, and clinical considerations from previously described typical RBD with onset >50years. ...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2012.09.026

    authors： Ju YE

    更新日期：2013-08-01 00:00:00

  • Sleep quality and gestational diabetes in pregnant women: a systematic review and meta-analysis.

    abstract：:Poor sleep quality is very common among pregnant women. Gestational diabetes mellitus (GDM) has been related to various adverse maternal and neonatal outcomes. The aim of this systematic review was to examine the association between poor sleep quality and gestational diabetes risk. Following the Preferred Reporting It...

    journal_title：Sleep medicine

    pub_type： 杂志文章,评审

    doi：10.1016/j.sleep.2019.11.1246

    authors： Zhu B,Shi C,Park CG,Reutrakul S

    更新日期：2020-03-01 00:00:00

  • Physiological relationship between autonomic reactions and arousals in infancy.

    abstract：OBJECTIVE:Changes in blood pressure (BP) were measured following auditory stimuli in the prone and the supine position to study the correlation between arousal from sleep and autonomic responses. METHOD:Two newborns born at term, two infants and four children were recorded polygraphically during one night, while sleep...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/s1389-9457(02)00165-x

    authors： Franco P,Van de Borne P,Chabanski S,Sawaguchi T,Horne R,Verheulpen D,Groswasser J,Kahn A

    更新日期：2002-12-01 00:00:00

  • Vitamins and sleep: an exploratory study.

    abstract：STUDY OBJECTIVE:We analyzed archival data from an epidemiology study to test the association between vitamin use and sleep. DESIGN:Random digit dialing was used to recruit 772 people ranging in age from 20 to 98 for a study of people's sleep experience. These individuals completed a set of questionnaires about their s...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2006.12.009

    authors： Lichstein KL,Payne KL,Soeffing JP,Heith Durrence H,Taylor DJ,Riedel BW,Bush AJ

    更新日期：2007-12-01 00:00:00

  • Sawtooth wave density analysis during REM sleep in temporal lobe epilepsy patients.

    abstract：BACKGROUND AND PURPOSE:This study analyzes sawtooth waves (STW), a characteristic feature of rapid eye movement (REM) sleep, in temporal lobe epilepsy patients in order to test the hypothesis of STW dysfunction in this population. METHODS:Polysomnographic records from 16 patients with temporal lobe epilepsy and 11 con...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2005.02.005

    authors： Vega-Bermudez F,Szczepanski S,Malow B,Sato S

    更新日期：2005-07-01 00:00:00

  • Genetic polymorphisms in the aryl hydrocarbon receptor-signaling pathway and sleep disturbances in middle-aged women.

    abstract：OBJECTIVE:We aimed to determine if selected genetic polymorphisms in the aryl hydrocarbon receptor (AHR)-signaling pathway and circadian locomotor output cycles kaput (CLOCK) are associated with insomnia and early awakening in middle-aged women. METHODS:Women aged 45 to 54years (n=639) were recruited into a middle-age...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/j.sleep.2013.04.007

    authors： Ziv-Gal A,Flaws JA,Mahoney MM,Miller SR,Zacur HA,Gallicchio L

    更新日期：2013-09-01 00:00:00

  • An examination of thought control strategies employed by acute and chronic insomniacs.

    abstract：STUDY OBJECTIVES:Theoretical accounts of the progression of insomnia from acute to chronic are lacking. A framework is proposed and tested to examine differences in cognitive coping styles between acute and chronic insomniacs and the relation of cognitive processing and sleep hygiene to causal attributions of insomnia....

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/s1389-9457(02)00039-4

    authors： Ellis J,Cropley M

    更新日期：2002-09-01 00:00:00

  • A clinical investigation of obstructive sleep apnea syndrome (OSAS) and upper airway resistance syndrome (UARS) patients.

    abstract：:Objective: (i) Evaluation of the clinical differences and similarities presented by patients diagnosed as OSAS and UARS subjects. (ii) Evaluation of the ability of a sleep disorders specialist to dissociate the two syndromes based upon clinical evaluation.Population: 314 subjects were included. They were referred to a...

    journal_title：Sleep medicine

    pub_type： 杂志文章

    doi：10.1016/s1389-9457(99)00011-8

    authors： Guilleminault C,Black JE,Palombini L,Ohayon M

    更新日期：2000-02-01 00:00:00