Abstract:
OBJECTIVE:We aimed to determine if selected genetic polymorphisms in the aryl hydrocarbon receptor (AHR)-signaling pathway and circadian locomotor output cycles kaput (CLOCK) are associated with insomnia and early awakening in middle-aged women. METHODS:Women aged 45 to 54years (n=639) were recruited into a middle-aged health study and agreed to complete questionnaires and donate blood samples. Questionnaires were used to assess sleep outcomes. Blood samples were processed for genotyping for the selected polymorphisms: AHR (rs2066853), AHR repressor (AHRR) (rs2292596), aryl hydrocarbon nuclear translocator (ARNT) (rs2228099), and CLOCK (rs1801260). Data were analyzed using multivariable logistic regression. RESULTS:Women heterozygous for the AHRR alleles (GC) had decreased odds of insomnia compared to women homozygous for the AHRR_C allele (adjusted odds ratio [aOR], 0.69; 95% confidence interval [CI], 0.49-0.96). Women with at least one of the AHRR_G or CLOCK_C alleles had significantly decreased odds of insomnia compared to women homozygous for the AHRR_C and CLOCK_T alleles (aOR, 0.64; 95% CI, 0.43-0.96). Additionally, women homozygous for the AHRR_G and CLOCK_C alleles had significantly decreased odds of insomnia compared to women homozygous for the AHRR_C and CLOCK_T alleles (aOR, 0.56; 95% CI, 0.35-0.89). None of the selected single nucleotide polymorphisms (SNPs) or combinations of SNPs were significantly associated with early awakening. CONCLUSIONS:Selected genetic polymorphisms in the AHR-signaling pathway (i.e., AHRR) and CLOCK may play a role in decreasing the risk for experiencing insomnia during the menopausal transition.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Ziv-Gal A,Flaws JA,Mahoney MM,Miller SR,Zacur HA,Gallicchio Ldoi
10.1016/j.sleep.2013.04.007subject
Has Abstractpub_date
2013-09-01 00:00:00pages
883-7issue
9eissn
1389-9457issn
1878-5506pii
S1389-9457(13)00139-1journal_volume
14pub_type
杂志文章相关文献
SLEEP MEDICINE文献大全abstract:OBJECTIVES:Oral appliances for the treatment of obstructive sleep apnea (OSA) reduce upper airway collapse by advancing the mandible (OAm) and associated soft tissues. OAm are well tolerated but have side effects, mainly dental movement. It is not yet clear whether there are irreversible skeletal changes associated wit...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.12.012
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To assess the association between sleep duration and physical activity and dietary behaviors among adolescents in a representative sample. METHODS:The analysis was performed using data from the 2015 Ningbo Youth Risk Behavior Survey. Associations between physical activity and dietary behaviors and sleep dura...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.06.024
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS:42 DSWPD (22 female, mean age 34.5 y) and 26 (±4 years) age-and-sex-matched controls (12 female...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.09.009
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Machado-Joseph disease (MJD) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as Parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. Some data have demonstrated a high frequency of sl...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2013.09.025
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To investigate the associations between sleep disturbances in mid-life and late-life and late-life cognitive status. METHODS:In four population-based studies (three Swedish studies: H70 study, Kungsholmen Project (KP) and The Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD); and one Finnis...
journal_title:Sleep medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.sleep.2017.11.1149
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) is associated with increased cardiovascular morbidity and mortality which may be mediated by increased arterial stiffness and endothelial dysfunction. Continuous positive airway pressure (CPAP) therapy improves excessive daytime somnolence (EDS), but its effect on vascular funct...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2013.08.786
更新日期:2013-12-01 00:00:00
abstract::Objective: To replicate the left minus right (L-R) hemisphere EEG power shifts coupled to rapid eye movement (REM) and non-rapid eye movement (NREM) sleep observed in 1972 by Goldstein (Physiol Behav (1972) 811), and to characterize the L-R EEG power spectra for total EEG, delta, theta, alpha and beta bands.Background...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(00)00066-6
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:In obstructive sleep apnea syndrome (OSAS), any of the activated neural, vascular, hemodynamic, metabolic, inflammatory, and thrombotic mechanisms may be related to increased cerebrovascular disease and risk of death; however, the possible pathophysiological process between obstructive sleep apnea syndrome an...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.09.020
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVES:The present study aimed to clarify the prevalence and risk factors of insomnia among public school teachers in Japan by examining the relationships between working hours, commuting time, and insomnia. Time spent on work activities among teachers with insomnia was also investigated. METHODS:This study was a ...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2019.09.017
更新日期:2020-11-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to evaluate if there is a significant effect of lunar phases on subjective and objective sleep variables in the general population. METHODS:A total of 2125 individuals (51.2% women, age 58.8 ± 11.2 years) participating in a population-based cohort study underwent a complete polys...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2015.08.002
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:Behavioral and physiological indexes of high sleep inertia (SI) characterize the awakening from recovery (REC) sleep after prolonged wakefulness, but the associated electroencephalogram (EEG) topography has never been investigated. Here, we compare the EEG topography following the awakening from baseline (BSL...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2015.03.009
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To examine the presence and characteristics of idiopathic REM sleep behavior disorder (IRBD) in a representative Caucasian sample from the elderly community of Lleida, Spain, attending primary care centers. METHODS:Participants were individuals aged 60 years or older who underwent routine visits in two prima...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.07.021
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Many studies have shown a U-shaped association of sleep duration with mortality; however, this association is difficult to interpret owing to possible reverse causation, residual confounding, and measurement issues. We used data from the Women's Health Initiative to examine the associations of slee...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2018.05.015
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVES/BACKGROUND:We assessed prevalence and correlates of insomnia; associations between changes in insomnia with incidence of physical, emotional, and mixed impairments (PI, EI, and MI, respectively); and age as a moderator in these relationships. PARTICIPANTS/METHODS:The Women's Health Initiative (WHI) clinical...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2014.11.008
更新日期:2015-03-01 00:00:00
abstract::We describe the first reported case of subclinical rhythmic electrographic discharge of adults (SREDA) during rapid eye movement (REM) sleep. This 48-year-old man, with a history of witnessed apneic spells, was sent for a baseline polysomnogram. Besides demonstrating obstructive sleep apnea, his study showed the occur...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2003.06.001
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To create a sleep duration classification technique for waist-worn ActiGraph accelerometers in preschool-aged children. METHODS:Children wore ActiGraph wGT3X-BT accelerometers on their right hip for 7 days (24 h/day). Ground truth nap, sleep, and wake were estimated through visual inspection of accelerometer...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.12.019
更新日期:2021-01-08 00:00:00
abstract:OBJECTIVES:Despite routine use with older adults, the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) have not been adequately validated in older samples, particularly those from diverse racial backgrounds. The objective of this study was to determine the reliability and validity of and to prov...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2011.04.005
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Some patients with obstructive sleep apnea/hypopnea syndrome (OSA/HS) who are regular users of nasal continuous positive airway pressure (nCPAP) therapy continue to experience daytime sleepiness that impairs performance and quality of life. A randomized, double-blind, placebo-controlled, parallel-group study...
journal_title:Sleep medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s1389-9457(03)00108-4
更新日期:2003-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although upper airway collapsibility (UAC) is theoretically useful to anticipate severity of sleep-disordered breathing (SDB), inspiratory UAC measurements are poorly correlated with obstructive sleep apnea (OSA) severity. PATIENTS AND METHODS:We investigated in 15 healthy and 35 SDB awake subje...
journal_title:Sleep medicine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.sleep.2004.10.013
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To describe the treatment response with melatonin for rapid eye movement (REM) sleep behavior disorder (RBD) associated with other neurologic disorders. BACKGROUND:Clonazepam has been considered the treatment of choice for RBD. However, an alternative treatment is desirable for those with RBD refractory to c...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(03)00072-8
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy and safety profile of gaboxadol, a selective extrasynaptic GABA(A) agonist (SEGA) previously in development for the treatment of insomnia. METHODS:This was a randomised, double-blind, placebo-controlled, parallel-group, 2-week, Phase III study of gaboxadol 5, 10 and 15mg in outpatie...
journal_title:Sleep medicine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.sleep.2008.09.010
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:Nocturnal eating behavior is shared by patients affected by a parasomnia, sleep-related eating disorder (SRED), and several eating disorders such as night eating syndrome (NES) and binge-eating disorder (BED); however, the differential clinical features of these patients have been poorly studied, with persist...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2014.12.020
更新日期:2015-06-01 00:00:00
abstract::Sleep disturbances are common in extrapyramidal diseases, including not only insomnia but excessive daytime sleepiness and parasomnias. In particular, complaints related to sleep are extremely common among patients affected by Parkinson's disease (PD). The underlying causes may include: patient age, associated illness...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2003.10.012
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:To assess the impact of three hypopnea definitions on the severity classification of obstructive sleep apnea (OSA) and its association with cardiovascular mortality risk in women and elderly individuals. METHODS:We analyzed two Spanish clinical cohorts (1116 women and 939 elderly individuals) who were studie...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2016.05.020
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Observational evidence suggests that atypical antipsychotics such as quetiapine are increasingly being used to manage insomnia. This is concerning given the uncertain efficacy and potential adverse effects associated with these medications. OBJECTIVES:The objectives of this study are to evaluate the benefit...
journal_title:Sleep medicine
pub_type: 杂志文章,评审
doi:10.1016/j.sleep.2016.04.003
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:In some patients with obstructive sleep apnea (OSA), Epworth Sleepiness Scale scores (ESS) do not reflect the severity of disease. In many cases, bed partners (BPs) report more severe hypersomnia on the part of the patient than the patient him/herself. The purpose of this study was to assess the agreement be...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/s1389-9457(01)00079-x
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Obstructive sleep apnea (OSA) was shown to be associated with gestational diabetes mellitus (GDM). However, prevalence of OSA in GDM women, its relationship to metabolic control, and predictive factors have not been studied. MATERIAL AND METHODS:Eighty-two obese pregnant women with diet-controlled GDM betwe...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2017.08.010
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to measure the relationship between sleep quality and health-related quality of life (HRQOL), in Indian population with type 2 diabetes mellitus (T2DM). METHODS:A cross-sectional study, included a total of 300 patients with T2DM. All participants were responding to the Pittsbur...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.04.022
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:During the outbreak of the COVID-19 pandemic in 2020, high schools closed or transitioned to remote teaching. The aim of this study was to describe how the COVID-19 related school shutdown impacted the sleep behaviors of typically developing adolescents. METHODS:A qualitative study was conducted between Apri...
journal_title:Sleep medicine
pub_type: 杂志文章
doi:10.1016/j.sleep.2020.09.015
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This randomized, double-blind, placebo-controlled study assessed the efficacy and safety of eszopiclone, a non-benzodiazepine hypnotic agent, in healthy adults using the first-night effect model of transient insomnia. PATIENTS AND METHODS:A total of 436 healthy, normal sleeping participants were...
journal_title:Sleep medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.sleep.2004.09.001
更新日期:2005-01-01 00:00:00