Abstract：
:Functional neuroimaging studies may contribute to elucidate pathophysiological mechanisms of the restless legs syndrome (RLS) which still remain unclear. Studies in patients with RLS have been performed using functional magnetic resonance imaging (fMRI), single photon emission computed tomography (SPECT) and, more recently, positron emission tomography (PET). SPECT and PET studies revealed some controversial results of the pre- and postsynaptic dopaminergic neurotransmission system and cerebral metabolism in RLS probably reflecting a dysfunction of the central dopaminergic system. However, it still has to be determined whether these alterations affect the nigrostriatal and/or other central dopaminergic systems like the diencephalospinal or mesolimbic pathway and whether they are the primary mechanisms or only secondary phenomena within the manifestation of RLS symptoms. A subtle receptor dysfunction or a synaptic dopaminergic deficit may play a major role. fMRI investigations of RLS patients revealed an activation in the red nuclei and brainstem close to the reticular formation during the symptomatic period, suggesting that subcortical cerebral generators are involved in the pathogenesis of RLS. However, both techniques are not yet clinically relevant methods to differentiate RLS from other movement disorders during sleep. Further investigations, especially at night when RLS symptoms are most pronounced, will lead to a better understanding of the mechanisms underlying RLS.
journal_name
Sleep Medjournal_title
Sleep medicineauthors
Wetter TC,Eisensehr I,Trenkwalder Cdoi
10.1016/j.sleep.2004.01.009keywords:
subject
Has Abstractpub_date
2004-07-01 00:00:00pages
401-6issue
4eissn
1389-9457issn
1878-5506pii
S1389945704000218journal_volume
5pub_type
杂志文章,评审相关文献
SLEEP MEDICINE文献大全abstract：:A multiple sleep latency test (MSLT) with occurrence of sleep onset REM periods (SOREMP) is considered one of the central diagnostic criteria for narcolepsy according to the International Classification of Sleep Disorders, but its sensitivity and specificity have been questioned. This study aims to describe MSLT and p...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.12.037
更新日期：2021-01-02 00:00:00
abstract：BACKGROUND AND PURPOSE:This study was conducted to demonstrate the long-term efficacy of sodium oxybate for the long-term treatment of cataplexy in patients with narcolepsy. PATIENTS AND METHODS:Fifty-five (55) narcoleptic patients with cataplexy who had received continuous treatment with sodium oxybate for 7-44 month...
journal_title：Sleep medicine
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.sleep.2003.11.002
更新日期：2004-03-01 00:00:00
abstract：OBJECTIVE:Little is known about the prevalence and impact of insomnia on clinical outcomes in youth with obsessive-compulsive disorder (OCD). This study aimed to investigate this subject. PATIENTS/METHODS:A total of 193 patients from a specialist pediatric OCD clinic completed a range of diagnostic and clinical measur...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2018.12.024
更新日期：2019-04-01 00:00:00
abstract：OBJECTIVE:To explore the correlates of nocturnal sleep duration, nocturnal sleep variability, and nocturnal sleep problems in a sample of Australian toddlers. METHODS:Participants were 173 toddlers (average age 19.7 ± 4.1 months) from the GET UP! STUDY:Nocturnal sleep duration, nocturnal sleep variability, nap(s) and...
journal_title：Sleep medicine
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.sleep.2018.08.035
更新日期：2019-01-01 00:00:00
abstract：OBJECTIVE:The aim of the present study was to investigate the impact of sleep on osteoporosis. METHODS:The study used a baseline examination of the Hiroshima Sleep and Healthcare study, which was a cross-sectional and cohort study that addressed the association of sleep habits with lifestyle-related diseases. A total ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.06.029
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVES:This study aimed to evaluate children's bedtime, wake-up time, total sleep duration (TSD), sleep latency, and daytime napping by age and gender. Its secondary aim was to compare sleep duration among demographic and lifestyle factors. METHODS:We performed a cross-sectional study of 3639 children in Daegu, Ko...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.03.011
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Prior studies report less favorable sleep characteristics among non-Whites as compared with non-Hispanic Whites. However, few population-based studies have used objective measures of sleep duration, especially in more than two racial/ethnic groups. We tested whether objectively estimated sleep duration and s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.07.005
更新日期：2016-02-01 00:00:00
abstract：OBJECTIVE/BACKGROUND:Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common type of autosomal dominant spinocerebellar ataxia (SCA). Sleep disorders have been described as frequent non-motor symptoms in MJD, and with marked impairment on quality of life. However, few studies have evalua...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2018.04.002
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Infancy is a period of rapid development when the quality of caregiving behavior may be particularly consequential for children's long-term functioning. During this critical period for caregiving behavior, parents experience changes in their sleep that may affect their ability to provide sensitive ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2019.07.017
更新日期：2020-01-01 00:00:00
abstract：OBJECTIVES:Despite routine use with older adults, the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) have not been adequately validated in older samples, particularly those from diverse racial backgrounds. The objective of this study was to determine the reliability and validity of and to prov...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2011.04.005
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Birth order may play a role in autoimmune diseases and early childhood infections, both factors implicated in the etiology of narcolepsy. We investigated the association between birth order and narcolepsy risk in a population-based case-control study in which all study subjects were HLA-DQB1*0602 positive. ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2011.09.010
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:Odor identification and discrimination are reduced in subjects with obstructive sleep apnea syndrome (OSAS), but the pathophysiology of the olfactory dysfunction in OSAS is still poorly understood. Experimental evidence suggests that olfactory impairment could be related to central cholinergic dysf...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2017.06.021
更新日期：2017-09-01 00:00:00
abstract：:Depression is a significant public health issue, made worse by the absence of response to antidepressant medications by many patients. Given the high degree of overlap between sleep and circadian complaints and depression, chronotherapies are a promising avenue for novel, effective, and fast-acting treatments for depr...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2019.04.012
更新日期：2019-09-01 00:00:00
abstract：:We describe five patients who presented with irresistible daytime sleepiness and who have the clinical and laboratory features of narcolepsy but differ from most patients with narcolepsy in their ability to resist falling asleep during the daytime. All of the patients described partial or complete remission of their s...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(99)00016-7
更新日期：2000-04-01 00:00:00
abstract：:Vitamin D is a pro-hormone belonging to the category of the fat-soluble group of vitamins; it is obtained more from solar exposure and in smaller quantities through feeding. Although vitamin D has traditionally been shown to be involved in calcium homeostasis and bone health, recent studies have found a positive assoc...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2018.10.033
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Sleep restriction and sleep disorders are common causes of excessive daytime sleepiness (EDS). Medical disorders (MD) can also cause EDS, but previous studies have used non-standardized measures, selected samples, or have examined EDS in singular disorders. This study describes the relative degree of EDS a...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.04.010
更新日期：2010-10-01 00:00:00
abstract：BACKGROUND:Narcolepsy is often not recognized or accurately diagnosed. This may be due to the fact that cataplexy, a core symptom which is virtually 100% specific, can-in practice-only be diagnosed based on the patient's history. However, the current definition of cataplexy is not very precise and the common distinctio...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2010.05.010
更新日期：2011-01-01 00:00:00
abstract：STUDY OBJECTIVES:We investigated the moderation of caloric intake on the association between race/ethnicity and habitual sleep in adolescents. METHODS:We analyzed the data obtained from 324 adolescents who completed the follow-up examination of the Penn State Child Cohort study. We collected actigraphy-measured sleep ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.10.001
更新日期：2020-12-01 00:00:00
abstract：:Objective: To replicate the left minus right (L-R) hemisphere EEG power shifts coupled to rapid eye movement (REM) and non-rapid eye movement (NREM) sleep observed in 1972 by Goldstein (Physiol Behav (1972) 811), and to characterize the L-R EEG power spectra for total EEG, delta, theta, alpha and beta bands.Background...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/s1389-9457(00)00066-6
更新日期：2001-07-01 00:00:00
abstract：:This chapter addresses the use of long-term non-invasive positive pressure ventilation (NIPPV) (to the exclusion of continuous positive airway pressure) in the different clinical settings in which it is currently proposed: principally in diseases responsible for hypoventilation characterized by elevated PaCO(2). Nasal...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2007.03.009
更新日期：2007-06-01 00:00:00
abstract：OBJECTIVE:To characterize the patterns of light exposure and physical activity level and assess their relationship with sleep quality and depressive symptoms in adults with delayed sleep-wake phase disorder (DSWPD). METHODS:42 DSWPD (22 female, mean age 34.5 y) and 26 (±4 years) age-and-sex-matched controls (12 female...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2016.09.009
更新日期：2017-04-01 00:00:00
abstract：BACKGROUND:Hypoxia plays an important role in the development of solid tumors. Intermittent hypoxia is the hallmark of sleep apnea (SA). We tested the hypothesis that SA may increase the risk of breast cancer in Taiwan by using a population-based data set. METHODS:Our study cohort consisted of women diagnosed with SA ...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2014.05.026
更新日期：2014-09-01 00:00:00
abstract：:In addition to being necessary for vision, light also plays a primary role in circadian physiology. Humans are diurnal animals and their biological clock synchronizes their physiological functions in such a way that functions associated with activity happen in the daytime while functions associated with rest occur at ...
journal_title：Sleep medicine
pub_type： 杂志文章,评审
doi：10.1016/j.sleep.2006.11.008
更新日期：2007-09-01 00:00:00
abstract：STUDY OBJECTIVES:To examine the associations between screen time, the time spent on different screen devices, and sleep in a sample of Finnish preschool children. METHODS:The current study analyzed cross-sectional data from the DAGIS study carried out in Finland in 2015-2016 on 736 children aged 3-6 years. Parents rep...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2020.11.008
更新日期：2020-11-11 00:00:00
abstract：BACKGROUND AND PURPOSE:Although benzodiazepines (BZDs) are commonly used in the treatment of insomnia, there is little information about psychological, health, and sociodemographic correlates associated with their use. OBJECTIVE:This study examined correlates of benzodiazepine use for sleep in a clinical sample of pat...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2004.04.001
更新日期：2004-09-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Using transcranial B-mode sonography (TCS), the first morphological marker for restless legs syndrome (RLS), hypoechogenicity of the substantia nigra (SN) has been found. The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to i...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2007.09.001
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND AND PURPOSE:To estimate prevalence and severity (using the International Restless Legs Syndrome Study Group Rating Scale (IRLS)) and to identify risk factors of restless legs syndrome (RLS). PATIENTS AND METHODS:Population-based cross-sectional study; 2005 randomly selected adults 18 years and above partici...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2005.03.008
更新日期：2005-07-01 00:00:00
abstract：OBJECTIVE:Poor sleep may be a risk factor for obesity. Previous studies have mainly investigated the effects of sleep duration on body mass index, but research considering overall sleep quality and other anthropometric measures is scarce. The aim of this study was to examine the association between sleep quality and di...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.05.023
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVES:Sleep-disordered breathing (SDB) is very common in acute stroke patients and has been related to poor outcome. However, there is a lack of data about the association between SDB and stroke in developing countries. The study aims to characterize the frequency and severity of SDB in Brazilian patients during t...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2015.11.008
更新日期：2016-03-01 00:00:00
abstract：OBJECTIVES:To compare individuals with traumatic brain injury (TBI) to healthy controls (CTLs) on measures of sleepiness, fatigue, and sleep, and explore correlates of sleepiness and fatigue separately for each group. METHODS:Participants were 22 adults with moderate/severe TBI (time since injury ≥ 1 year; mean=53.0 ±...
journal_title：Sleep medicine
pub_type： 杂志文章
doi：10.1016/j.sleep.2012.02.010
更新日期：2012-06-01 00:00:00
