Preoperative Tumor Markers Independently Predict Survival in Stage III Gastric Cancer Patients: Should We Include Tumor Markers in AJCC Staging?

Abstract:

OBJECTIVE:The aim of this study was to determine the prognostic significance of preoperative carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels in patients with resectable gastric cancer (GC). PATIENTS AND METHODS:Patients who underwent a radical resection for GC at the Fujian Medical University Union Hospital between 2007 and 2014 were included in this study. The estimated area under the curve (AUC) was compared to evaluate the discriminatory ability of tumor makers. Additional external validation was performed using a dataset from Sun Yat-sen University Cancer Center. RESULTS:Preoperative CEA/CA19-9 levels were identified as an independent predictor of overall survival (OS) and disease-specific survival (DSS) (both p < 0.05) in the development group. In a subgroup analysis based on TNM stage, preoperative CEA/CA19-9 levels clearly stratified the survival rates for stage III GC (p < 0.05). A multivariate analysis revealed that preoperative CEA/CA19-9 levels were an independent prognostic factor (p < 0.05) in stage III; the AUC of the preoperative CEA/CA19-9 was equivalent to that of T stage. A prediction model (TNMC) for stage III GC was developed by incorporating preoperative CEA/CA19-9 levels into the American Joint Committee on Cancer (AJCC) staging system. The AUC of the TNMC was significantly higher than that of the TNM staging system at 1, 3, and 5 years postoperatively (all p < 0.05), with similar results also being obtained in the external validation set. CONCLUSION:Preoperative CEA/CA19-9 levels are an independent predictor of OS and DSS in stage III GC patients. The inclusion of preoperative CEA/CA19-9 levels in AJCC TNM staging provided an optimal prognosis in stage III GC.

journal_name

Ann Surg Oncol

authors

Lin JX,Wang W,Lin JP,Xie JW,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu R,Zheng CH,Huang CM,Zhou ZW,Li P

doi

10.1245/s10434-018-6634-z

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2703-2712

issue

9

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-018-6634-z

journal_volume

25

pub_type

杂志文章
  • Oncologic Outcomes of Colon Cancer Patients with Extraregional Lymph Node Metastasis: Comparison of Isolated Paraaortic Lymph Node Metastasis with Resectable Liver Metastasis.

    abstract:BACKGROUND:The treatment strategy and benefit of extended lymph node dissection among patients with preoperatively diagnosed paraaortic lymph node metastasis (PALNM) in colon cancer remains highly controversial. In the current study, we analyzed the oncologic outcomes of patients who underwent extraregional lymph node ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-5027-9

    authors: Bae SU,Han YD,Cho MS,Hur H,Min BS,Baik SH,Lee KY,Kim NK

    更新日期:2016-05-01 00:00:00

  • Receptor Tyrosine Kinase Expression Predicts Response to Sunitinib in Breast Cancer.

    abstract:BACKGROUND:Preliminary data indicate that tyrosine kinase inhibitors (TKIs) function through rearranged during transfection (RET) in breast cancer. However, TKIs are not specific and can block several receptor tyrosine kinases (RTKs). This study used cell lines and primary breast cancer specimens to determine factors a...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4597-x

    authors: Spanheimer PM,Lorenzen AW,De Andrade JP,Kulak MV,Carr JC,Woodfield GW,Sugg SL,Weigel RJ

    更新日期:2015-12-01 00:00:00

  • Sentinel lymph node biopsy in pediatric and adolescent cutaneous melanoma patients.

    abstract:BACKGROUND:The rarity of melanoma in young patients, particularly pediatric ones, has to date precluded any valid comparisons being made between young patients and adults undergoing sentinel lymph node biopsy (SLNB) for intermediate thickness localized melanoma. The present study takes advantage of the large Sydney Mel...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0657-4

    authors: Howman-Giles R,Shaw HM,Scolyer RA,Murali R,Wilmott J,McCarthy SW,Uren RF,Thompson JF

    更新日期:2010-01-01 00:00:00

  • Impact of Sarcopenic Obesity on Failure to Rescue from Major Complications Following Pancreaticoduodenectomy for Cancer: Results from a Multicenter Study.

    abstract:BACKGROUND:Failure to rescue (FTR) is a quality-of-care indicator in pancreatic surgery, but may also identify patients who may not tolerate major postoperative complications despite being treated with best available care. Previous studies found that high visceral adipose tissue-to-skeletal muscle ratio is associated w...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-017-6216-5

    authors: Pecorelli N,Capretti G,Sandini M,Damascelli A,Cristel G,De Cobelli F,Gianotti L,Zerbi A,Braga M

    更新日期:2018-01-01 00:00:00

  • Intra-operative sonography: a valuable aid during breast-conserving surgery for occult breast cancer.

    abstract:BACKGROUND:Breast cancer is increasingly detected during an early non-palpable stage. Together with pre-operative marking of the mass, intra-operative imaging provides invaluable clues. This study was designed to evaluate the usefulness of intra-operative sonography in the hands of the surgeon. METHODS:Between July 20...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9490-9

    authors: Haid A,Knauer M,Dunzinger S,Jasarevic Z,Köberle-Wührer R,Schuster A,Toeppker M,Haid B,Wenzl E,Offner F

    更新日期:2007-11-01 00:00:00

  • Axillary failure in patients treated with MammoSite accelerated partial breast irradiation.

    abstract:BACKGROUND:The risk of axillary failure (AF) after accelerated partial breast irradiation (APBI) using MammoSite brachytherapy is unknown and has been source of concern as the axillary region is not treated with this technique. We aimed to determine the rate of AF in patients treated with APBI and identify factors asso...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-011-1734-z

    authors: Aburabia M,Roses RE,Kuerer HM,Fine R,Beitsch PD,Goyal S,Haffty B,Lyden M,Vicini FA

    更新日期:2011-11-01 00:00:00

  • Impact and outcomes of routine microstaging of sentinel lymph nodes in breast cancer: significance of the pN0(i+) and pN1mi categories.

    abstract:BACKGROUND:In 2003, the American Joint Committee on Cancer (AJCC) initiated the 6th edition staging criteria, including pN0(i+) and pN1mi categories for breast cancer. However, the clinical significance of these categories is debated in the literature. METHODS:A prospective registry was used to identify patients stage...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-008-0121-x

    authors: Pugliese MS,Beatty JD,Tickman RJ,Allison KH,Atwood MK,Szymonifka J,Arthurs ZM,Huynh PP,Dawson JH

    更新日期:2009-01-01 00:00:00

  • Increasing the Number of Examined Lymph Nodes is a Prerequisite for Improvement in the Accurate Evaluation of Overall Survival of Node-Negative Gastric Cancer Patients.

    abstract:BACKGROUND:This study aims to elucidate whether increasing the number of examined lymph nodes (NELN) is mandatory for the accurate prognosis of node-negative gastric cancer (GC) patients after curative gastrectomy in Eastern countries (China and Japan). METHODS:The clinicopathological data of 2455 GC patients (includi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-016-5513-8

    authors: Deng J,Yamashita H,Seto Y,Liang H

    更新日期:2017-03-01 00:00:00

  • Defining the Safety Profile for Performing Pancreatoduodenectomy in the Setting of Hyperbilirubinemia.

    abstract:BACKGROUND:Hyperbilirubinemia is commonly observed in patients requiring pancreatoduodenectomy (PD). Thus far, literature regarding the danger of operating in the setting of hyperbilirubinemia is equivocal. What remains undefined is at what specific level of bilirubin there is an adverse safety profile for undergoing P...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-08044-w

    authors: Chen B,Trudeau MT,Maggino L,Ecker BL,Keele LJ,DeMatteo RP,Drebin JA,Fraker DL,Lee MK 4th,Roses RE,Vollmer CM Jr

    更新日期:2020-05-01 00:00:00

  • Prognostic Impact of Preoperative Nutritional Risk in Patients Who Undergo Surgery for Pancreatic Adenocarcinoma.

    abstract:BACKGROUND:Nutritional derangements are common hallmarks of pancreatic cancer (PC). Their early detection and management are usually overlooked in routine practice. This study aimed to explore preoperative nutritional status and its prognostic value in patients undergoing surgery for PC. METHODS:Data from 73 patients ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08515-5

    authors: Trestini I,Paiella S,Sandini M,Sperduti I,Elio G,Pollini T,Melisi D,Auriemma A,Soldà C,Bonaiuto C,Tregnago D,Avancini A,Secchettin E,Bonamini D,Lanza M,Pilotto S,Malleo G,Salvia R,Bovo C,Gianotti L,Bassi C,Milel

    更新日期:2020-12-01 00:00:00

  • Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients.

    abstract:BACKGROUND:Pretreatment evaluation of axillary lymph nodes (ALNs) and marking of biopsied nodes in patients with newly diagnosed breast cancer is becoming routine practice. We sought to test tattooing of biopsied ALNs with a sterile black carbon suspension (Spot™). The intraoperative success of identifying tattooed ALN...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4034-6

    authors: Choy N,Lipson J,Porter C,Ozawa M,Kieryn A,Pal S,Kao J,Trinh L,Wheeler A,Ikeda D,Jensen K,Allison K,Wapnir I

    更新日期:2015-02-01 00:00:00

  • Follow-Up Recommendations after Diagnosis of Primary Cutaneous Melanoma: A Population-Based Study in New South Wales, Australia.

    abstract:BACKGROUND:Follow-up practices after diagnosis and treatment of primary cutaneous melanoma vary considerably. We aimed to determine factors associated with recommendations for follow-up setting, frequency, skin surveillance, and concordance with clinical guidelines. METHODS:The population-based Melanoma Patterns of Ca...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6319-z

    authors: Read RL,Madronio CM,Cust AE,Goumas C,Watts CG,Menzies S,Curtin AM,Mann G,Thompson JF,Morton RL

    更新日期:2018-03-01 00:00:00

  • Factors Associated with Reoperation in Breast-Conserving Surgery for Cancer: A Prospective Study of American Society of Breast Surgeon Members.

    abstract:BACKGROUND:More than 20% of patients undergoing initial breast-conserving surgery (BCS) for cancer require reoperation. To address this concern, the American Society of Breast Surgeons (ASBrS) endorsed 10 processes of care (tools) in 2015 to be considered by surgeons to de-escalate reoperations. In a planned follow-up,...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07547-w

    authors: Landercasper J,Borgert AJ,Fayanju OM,Cody H 3rd,Feldman S,Greenberg C,Linebarger J,Pockaj B,Wilke L

    更新日期:2019-10-01 00:00:00

  • Urinary diversion after total pelvic exenteration for rectal cancer.

    abstract:BACKGROUND:Total cystectomy is indicated for the treatment of bulky primary rectal cancers as well as previously treated, locally recurrent tumors that invade the bladder, prostate, seminal vesicle, or urethra. We review a 10-year Memorial Sloan-Kettering Cancer Center experience with urinary diversion in this setting....

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10434-999-0732-x

    authors: Russo P,Ravindran B,Katz J,Paty P,Guillem J,Cohen AM

    更新日期:1999-12-01 00:00:00

  • Comprehensive needs assessment of clinical breast evaluation skills of primary care residents.

    abstract:BACKGROUND:Health care reform places primary care (PC) physicians in an increasingly significant role for breast cancer screening and diagnosis. This study assessed the adequacy of traditional PC resident training to prepare physicians for this front-line role. METHODS:Sixty-eight primary care residents, representing ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303850

    authors: Chalabian J,Formenti S,Russell C,Pearce J,Dunnington G

    更新日期:1998-03-01 00:00:00

  • Decreased expression of FOXJ1 is a potential prognostic predictor for progression and poor survival of gastric cancer.

    abstract:BACKGROUND:FOXJ1 is a member of the forkhead transcription factor family, which has been mostly studied for its role in the development of ciliated epithelium and immunology. However, the role of FOXJ1 in tumorigenesis remains largely unknown or even conflicting. We thus investigated FOXJ1 expression in gastric cancer ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3742-2

    authors: Wang J,Cai X,Xia L,Zhou J,Xin J,Liu M,Shang X,Liu J,Li X,Chen Z,Nie Y,Fan D

    更新日期:2015-02-01 00:00:00

  • A Temperature of 40 °C Appears to be a Critical Threshold for Potentiating Cytotoxic Chemotherapy In Vitro and in Peritoneal Carcinomatosis Patients Undergoing HIPEC.

    abstract:BACKGROUND:Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a radical but effective treatment option for patients with peritoneal carcinomatosis (PC). Unfortunately, a standardized HIPEC protocol is missing impeding systematic comparisons with regard to minimal effective temperatures...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4853-0

    authors: Schaaf L,van der Kuip H,Zopf W,Winter S,Münch M,Mürdter TE,Thon KP,Steurer W,Aulitzky WE,Ulmer C

    更新日期:2015-12-01 00:00:00

  • The association of surgical margins and local recurrence in women with early-stage invasive breast cancer treated with breast-conserving therapy: a meta-analysis.

    abstract:PURPOSE:There is no consensus on what constitutes adequate negative margins in breast-conserving therapy (BCT). We systematically review the evidence on surgical margins in BCT for invasive breast cancer to support the development of clinical guidelines. METHODS:Study-level meta-analysis of studies reporting local rec...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-014-3480-5

    authors: Houssami N,Macaskill P,Marinovich ML,Morrow M

    更新日期:2014-03-01 00:00:00

  • Lymph node ratio: role in the staging of node-positive colon cancer.

    abstract:BACKGROUND:Recent literature has shown that lymph node ratio (LNR) is superior to the number of positive lymph nodes (pLNs) in predicting the prognosis in several malignances other than colon cancer. We hypothesize that LNR may play a similar role in stage III colon cancer. METHODS:We included 24,477 stage III colon c...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-007-9716-x

    authors: Wang J,Hassett JM,Dayton MT,Kulaylat MN

    更新日期:2008-06-01 00:00:00

  • Isolated Limb Perfusion for Melanoma is Safe and Effective in Elderly Patients.

    abstract:BACKGROUND:Data on isolated limb perfusion (ILP) in elderly melanoma patients are scarce. We aimed to evaluate the efficacy and safety of ILP in our institutional cohort of melanoma patients. METHODS:We performed retrospective analysis of stage IIIB/C melanoma patients who underwent ILP for melanoma in-transit metasta...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5803-9

    authors: Madu MF,Deken MM,van der Hage JA,Jóźwiak K,Wouters MWJM,van Akkooi ACJ

    更新日期:2017-07-01 00:00:00

  • Cavity Shaving Reduces Involved Margins and Reinterventions Without Increasing Costs in Breast-Conserving Surgery: A Propensity Score-Matched Study.

    abstract:BACKGROUND:Currently, reinterventions for involved margins after breast-conserving surgery remain common. The aim of this study was to assess the capability of the cavity shave margins (CSM) technique to reduce positive margin rates and reoperations compared with simple lumpectomy (SL). The impact of CSM on the various...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5774-x

    authors: Corsi F,Sorrentino L,Bonzini M,Bossi D,Truffi M,Amadori R,Nebuloni M,Brillat B,Mazzucchelli S

    更新日期:2017-06-01 00:00:00

  • Identification of Patients for Adjuvant Therapy After Resection of Carcinoma of the Extrahepatic Bile Ducts: A Propensity Score-Matched Analysis.

    abstract:BACKGROUND:Resectability rates for extrahepatic cholangiocarcinoma have increased over time, but long-term survival after resection alone with curative intent remains poor. Recent series suggest improved survival with adjuvant therapy. Patient subsets benefiting most from adjuvant therapy have not been clearly defined....

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6095-9

    authors: Ecker BL,Vining CC,Roses RE,Maggino L,Lee MK,Drebin JA,Fraker DL,Vollmer CM Jr,Datta J

    更新日期:2017-12-01 00:00:00

  • Effect of body composition on outcomes after hepatic resection for hepatocellular carcinoma.

    abstract:PURPOSE:To evaluate the effect of body composition on outcomes after hepatic resection for patients with hepatocellular carcinoma (HCC). METHODS:We performed 190 hepatic resections for HCC and divided the patients into 2 groups on the basis of visceral fat area (VFA), assessed by computed tomographic measurement at th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3686-6

    authors: Itoh S,Shirabe K,Matsumoto Y,Yoshiya S,Muto J,Harimoto N,Yamashita Y,Ikegami T,Yoshizumi T,Nishie A,Maehara Y

    更新日期:2014-09-01 00:00:00

  • Clinicopathological Features and Outcome of Lung Cancer Patients with Hematological Malignancy.

    abstract:PURPOSE:The aim of this study was to report the incidence of lung cancer in patients with hematological malignancy (HM), as well as patient characteristics and outcome. METHODS:We investigated 1503 consecutive patients treated for HM and 1208 patients who underwent surgical resection for lung cancer. RESULTS:Lung can...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4885-5

    authors: Shoji F,Yamazaki K,Kouso H,Mori R,Takase K,Okamura S,Takeo S

    更新日期:2016-02-01 00:00:00

  • Chemotherapy with or Without Definitive Radiation Therapy in Inoperable Pancreatic Cancer.

    abstract:BACKGROUND:The LAP07 randomized trial calls into question the role of radiation therapy (RT) in the modern treatment of locally advanced pancreatic cancer (LAPC). However, advances in chemotherapy and RT limit application of the LAP07 results to current clinical practice. Here we utilize the National Cancer Database (N...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-6322-4

    authors: Zhong J,Switchenko J,Behera M,Kooby D,Maithel SK,McDonald MW,Lin JY,Cassidy RJ,El-Rayes B,Landry J,Patel PR

    更新日期:2018-04-01 00:00:00

  • Triple Mapping to Optimize Axillary Management in Breast Cancer Patients After Neoadjuvant Therapy.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-018-6645-9

    authors: Shilad S,Cakmakoglu C,Schwarz G,Valente S,Djohan R,Grobmyer S

    更新日期:2018-10-01 00:00:00

  • Wilms tumor presenting with abdominal pain: a special subgroup of patients.

    abstract:BACKGROUND:Although significant progress has been made in the management of children with Wilms tumor, two major controversies still exist: the extent of radiographic evaluation necessary before surgery and the role of preoperative chemotherapy. This study sought to determine whether patients with Wilms tumor who prese...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303774

    authors: Davidoff AM,Soutter AD,Shochat SJ

    更新日期:1998-04-01 00:00:00

  • Impact of Patient Age on the Postoperative Survival in Pancreatic Head Cancer.

    abstract:BACKGROUND:Some reports have stated that pancreatoduodenectomy for elderly patients have comparable morbidity and mortality to that of young patients. However, the long-term outcomes of these patients have not been fully evaluated, especially for pancreatic head cancer. METHODS:A total of 227 patients who underwent pa...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-017-5994-0

    authors: Sugiura T,Okamura Y,Ito T,Yamamoto Y,Ashida R,Uesaka K

    更新日期:2017-10-01 00:00:00

  • Outcomes of Lymph Node Dissection for Non-metastatic Pancreatic Neuroendocrine Tumors: A Propensity Score-Weighted Analysis of the National Cancer Database.

    abstract:BACKGROUND:Although the National Comprehensive Cancer Network (NCCN) guidelines recommend use of lymph node dissection (LND) in patients with pancreatic neuroendocrine tumors (pNETs) > 2 cm, there is limited evidence to support the association between use of LND and overall survival (OS). METHODS:Patients with resecte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-019-07506-5

    authors: Mao R,Zhao H,Li K,Luo S,Turner M,Cai JQ,Blazer D 3rd

    更新日期:2019-09-01 00:00:00

  • Targeting Cyclin-Dependent Kinases in Synovial Sarcoma: Palbociclib as a Potential Treatment for Synovial Sarcoma Patients.

    abstract:BACKGROUND:In synovial sarcomas alterations in the cyclin D1-CDK4/6-Rb axis have been described. Also, β-catenin, a cyclin D1 regulator, is often overexpressed. Additionally, studies have shown that the t(X;18) translocation influences tumor behavior partly through cyclin D1 activation. We investigated how alterations ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5341-x

    authors: Vlenterie M,Hillebrandt-Roeffen MH,Schaars EW,Flucke UE,Fleuren ED,Navis AC,Leenders WP,Versleijen-Jonkers YM,van der Graaf WT

    更新日期:2016-09-01 00:00:00