Hormonal pattern and testicular histology in patients with prostatic cancer after long-term treatment with a gonadotropin-releasing hormone agonist analogue.

Abstract:

:Seven patients suffering from prostatic cancer were treated with a depot form of D-Trp-6-luteinizing hormone-releasing hormone (LH-RH), a LH-RH agonist analogue (3 mg i.m. every 28 days) for a period of 24-32 months. The peptide induced a sharp and long-lasting inhibition of both gonadotropin and testosterone secretion. A sustained suppression of pituitary and testicular function was observed 40 days after the treatment was suspended. Testicular biopsies performed in all patients showed a marked impairment of Leydig cell mass and a complete spermatogenic arrest with a tubular derangement and fibrosis. Results indicate that the long-term continued gonadotropin-releasing hormone agonist analogue therapy induces not only a functional inhibition of testicular androgenesis but also anatomical testicular damage whose reversibility does not seem to be probable.

journal_name

Eur Urol

journal_title

European urology

authors

Giberti C,Barreca T,Martorana G,Truini M,Franceschini R,Rolandi E,Giuliani L

doi

10.1159/000473411

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

125-7

issue

1-2

eissn

0302-2838

issn

1873-7560

journal_volume

15

pub_type

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