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Expression of estrogen receptor alpha and beta mRNAs in prostate cancers treated with leuprorelin acetate.

Abstract：

OBJECTIVE:The discovery of a novel estrogen receptor (ER), ER-beta, has given rise to new possibilities regarding estrogen's roles in the prostate. Although ER-beta is reported to be expressed preferentially in the rat prostate, its expression in the human prostate and relationship to cancer development has not been investigated. Thus the purpose of the study was to examine mRNA levels of ER-alpha and ER-beta in benign prostatic hyperplasia and prostate carcinoma. METHODS:Samples of 15 prostate cancers obtained at radical prostatectomy were examined. All the patients had been maintained on androgen withdrawal therapy for at least 3 months. ER-alpha and ER-beta mRNAs were measured with a competitive PCR technique. RESULTS:Both ER-alpha and ER-beta mRNAs were detected in all of the prostate cancer tissues examined, as well as in PC3 and LNCap cells, although the levels varied among specimens. Interestingly, both types were significantly decreased in cases with lymph node metastasis. However, there was no correlation between ER mRNA levels and any other clinicopathological parameters. CONCLUSIONS:(1) Both ER-alpha and ER-beta mRNAs are expressed in prostate cancer and (2) expression of ER mRNA may not be related to cancer progression but may be negatively correlated with metastasis.

journal_name

Eur Urol

journal_title

European urology

authors

Maruyama S,Fujimoto N,Asano K,Ito A,Usui T

doi

10.1159/000020345

keywords:

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

635-9

issue

5

eissn

0302-2838

issn

1873-7560

pii

20345

journal_volume

38

pub_type

杂志文章

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