A novel in vivo porcine model of intervertebral disc degeneration induced by cryoinjury.

Abstract:

PURPOSE:Degenerative disc disease involves sequential events that lead to the loss of cells, a decrease in disc matrix production, disc dehydration, and alteration of its biomechanical properties. The aim of this study was to determine whether cryoinjury of the nucleus pulposus performed through endplate perforation contributes to disc degeneration and to compare this technique with standard methods. METHOD:Under general anesthesia, the lumbar discs of six pigs were exposed and randomly submitted to needle puncture of the annulus fibrosus (NeP), isolated endplate injury (EP), or cryoinjury using a 2.5-J Thompson cryoprobe applied through a single endplate perforation (EP+cryo). The remaining discs served as controls. Animals were sacrificed at two months and the harvested lumbar spines were submitted to CT scan and MRI investigations. Histologic analysis was performed to assess the degree of disc degeneration. RESULTS:CT scan showed that decrease in average disc height was more important after cryoinjury (49.3%) than after endplate perforation (16.9%) (P < 0.0001) or needle puncture (19.4%) (P < 0.0001). On MRI, the dehydration ratio was significantly more important after EP+cryo (60%) than after NP (40%) or EP (30%) (P < 0.0001). After cryoinjury, the histologic score developed for this study was significantly higher than after needle puncture or endplate perforation (P < 0.0001). CONCLUSIONS:Imaging and histological analysis showed that disc cryoinjury applied through endplate perforation was superior to the classical NeP and EP models to induce experimental disc degeneration. This model appears suitable for testing safety and efficacy of novel treatments of intervertebral disc degeneration.

journal_name

Int Orthop

authors

Flouzat-Lachaniette CH,Jullien N,Bouthors C,Beohou E,Laurent B,Bierling P,Dubory A,Rouard H

doi

10.1007/s00264-018-3971-2

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

2263-2272

issue

9

eissn

0341-2695

issn

1432-5195

pii

10.1007/s00264-018-3971-2

journal_volume

42

pub_type

杂志文章
  • Morphometric evaluation of the knee in Chinese population reveals sexual dimorphism and age-related differences.

    abstract:PURPOSE:Morphologic data of the knee is very important in the design of total knee prostheses. Generally, the designs of the total knee prostheses are based on the knee anatomy of Caucasian population. Moreover, in forensic medicine, a person's age and sex might be estimated by the shape of their knees. The aim of this...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-3826-x

    authors: Li K,Cavaignac E,Xu W,Cheng Q,Telmon N,Huang W

    更新日期:2018-10-01 00:00:00

  • Blood loss in computer-assisted mobile bearing total knee arthroplasty. A comparison of computer-assisted surgery with a conventional technique.

    abstract::Computer-assisted surgery (CAS) in total knee arthroplasty (TKA) could be useful in reducing the overall blood loss. A prospective randomised study was performed with two groups of 50 patients each of whom were treated for knee arthritis. Patients of group A were treated by a conventional standard procedure, while for...

    journal_title:International orthopaedics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00264-008-0651-7

    authors: Conteduca F,Massai F,Iorio R,Zanzotto E,Luzon D,Ferretti A

    更新日期:2009-12-01 00:00:00

  • Mini-invasive surgical repair of the Achilles tendon--does it reduce post-operative morbidity?

    abstract::The surgical benefit of minimally invasive tendo Achilles repair (n = 25) with early weight-bearing mobilisation after rupture of the tendo Achilles was compared with operative treatment using an open technique (n = 34) with full weight-bearing after 8 weeks of surgical repair. The minimally invasive technique provide...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-008-0564-5

    authors: Bhattacharyya M,Gerber B

    更新日期:2009-02-01 00:00:00

  • Fluoroscopy assessment during anterior minimally invasive hip replacement is more accurate than with the posterior approach.

    abstract:PURPOSE:Acetabular component position is important for stability and wear. Fluoroscopy can improve the accuracy of acetabular component placement in the posterior approach and the direct anterior approach (DAA). The purpose of this study was to determine if the direct anterior approach in the supine position facilitate...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2803-x

    authors: Ji W,Stewart N

    更新日期:2016-01-01 00:00:00

  • The gait of patients with one resurfacing and one replacement hip: a single blinded controlled study.

    abstract:PURPOSES:Post arthroplasty gait analysis has up till now been performed on subjects walking slowly on flat ground rather than challenging them at faster speeds or walking uphill. We therefore asked: (1) Is there a measurable difference in the performance of hip resurfacing arthroplasty (HRA) and total hip arthroplasty ...

    journal_title:International orthopaedics

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00264-013-1819-3

    authors: Aqil A,Drabu R,Bergmann JH,Masjedi M,Manning V,Andrews B,Muirhead-Allwood SK,Cobb JP

    更新日期:2013-05-01 00:00:00

  • Hallux sesamoid bones. Anatomical observations with special reference to osteoarthritis and hallux valgus.

    abstract::The normal characteristics of the hallux sesamoid bones were studied in 200 toes (100 dissections and 100 radiographs from patients with hallux valgus), and pathological changes were recorded. Normally each sesamoid articulated with a separate groove on the plantar surface of the first metatarsal head. A bony ridge on...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00267743

    authors: Aseyo D,Nathan H

    更新日期:1984-01-01 00:00:00

  • Press-fit stability of uncemented hemispheric acetabular components: a comparison of three porous coating systems.

    abstract::Cementless acetabular components require good initial fixation to allow bony in-growth. The initial press-fit stability, important for designs that do not rely on supplemental fixation, was examined for three designs with different porous coating systems: beads, fiber mesh, and plasma spray. The ability to withstand t...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-001-0314-4

    authors: Markel DC,Hora N,Grimm M

    更新日期:2002-01-01 00:00:00

  • [Role of intrafocal pinning in the treatment of wrist fractures].

    abstract::We have treated 350 displaced Colles fractures by percutaneous fixation with K wires arranged in a 'basket' formation, as described by Kapandji. This technique enables satisfactory stabilisation of the fragments and early mobilisation and rehabilitation, usually without the use of a plaster cast or brace. We describe ...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00266982

    authors: Nonnenmacher J,Kempf I

    更新日期:1988-01-01 00:00:00

  • Reverse total shoulder arthroplasty-from the most to the least common complication.

    abstract::Reverse total shoulder arthroplasty (RTSA) has been reported to be associated with a complication rate that is four times that of conventional total shoulder arthroplasty. It is the purpose of this article to identify and understand the most common and most serious complications of RTSA and to review current methods o...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-010-1125-2

    authors: Farshad M,Gerber C

    更新日期:2010-12-01 00:00:00

  • Atraumatic tendon handling during tendon repair.

    abstract::Two techniques are presented for atraumatic handling of tendon ends during repair of flexor and extensor tendons. If the tendon is cleanly transected, the suture is carried out by holding the tendon in nerve holding forceps. If debridement is needed, a slice is partly cut and used to handle the tendon; the slice is th...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640050080

    authors: Lanzetta M,Chollet A

    更新日期:1996-01-01 00:00:00

  • First hip arthroplasty register in Italy: 55,000 cases and 7 year follow-up.

    abstract::The Register for Orthopaedic Prosthetic Implantation (RIPO) has been prospectively collecting data on hip prostheses performed in all the orthopaedic units in the region Emilia-Romagna since January 2000. The register aims to determine the characteristics of patients, evaluate the effectiveness of prostheses, and allo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-007-0465-z

    authors: Stea S,Bordini B,De Clerico M,Petropulacos K,Toni A

    更新日期:2009-04-01 00:00:00

  • [Current trends in surgery of the spine].

    abstract::This paper is based on an invited lecture given at the SICOT 87 meeting in Munich. The topics discussed include: selective spinal arteriography in the management of tumours, which enables definition of the vascular supply of the cord and of the tumour and may facilitate preoperative embolisation; MRI, which allows vis...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/BF00266367

    authors: Roy-Camille R

    更新日期:1989-01-01 00:00:00

  • Partial weightbearing is not necessary after cementless total hip arthroplasty: a two-year prospective randomized study on 100 patients.

    abstract::The purpose of this study was to evaluate the effects of partial and full weightbearing after cementless total hip arthroplasty over a two year follow-up period. Fifty-nine women and 41 men (average age 61 years) received an uncemented Spotorno stem and were randomised into a full and a partial weightbearing group. No...

    journal_title:International orthopaedics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00264-010-1089-2

    authors: Markmiller M,Weiss T,Kreuz P,Rüter A,Konrad G

    更新日期:2011-08-01 00:00:00

  • Knee alignment in adolescents is correlated with participation in weight-bearing sports.

    abstract:PURPOSE:Weight-bearing sports might influence the alignment of the lower extremities during growth. The relationship between participation in weight-bearing sports and the alignment of the lower extremities in adolescents has not been adequately studied yet. The aim of the study was to investigate whether sports partic...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-018-4015-7

    authors: De Cock L,Dauwe J,Holzer LA,Bellemans J

    更新日期:2018-12-01 00:00:00

  • Experiments on antigenicity and osteogenicity in allotransplanted cancellous bone.

    abstract::This experimental study was undertaken in mice to investigate the procedures for storage of allogenic cancellous bone. Cancellous grafts were were stored at -80 degrees C, -196 degrees C or freeze dried. Grafts were implanted into a defect in the recipient's femur and after one week the cellular kinetic activity was a...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00178753

    authors: Mizutani A,Fujita T,Watanabe S,Sakakida K,Okada Y

    更新日期:1990-01-01 00:00:00

  • Femoral head fractures.

    abstract::This report includes six patients with femoral head fractures. Five were associated with posterior hip dislocation, of which one also had an ipsilateral trochanteric fracture. All were young adults who had been injured in automobile accidents. The protocol for management, indications for surgery and guidelines for eva...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s002640000209

    authors: Mostafa MM

    更新日期:2001-01-01 00:00:00

  • Treatment of fracture sequelae of the proximal humerus: anatomical vs reverse shoulder prosthesis.

    abstract::The treatment of complex humeral fractures or fracture-dislocations presents several challenges. Late complications such as malunion, avascular necrosis, or nonunion are frequent and often lead to articular incongruence. Patients can be severely handicapped, presenting with considerable pain, stiffness, and important ...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-014-2651-0

    authors: Mansat P,Bonnevialle N

    更新日期:2015-02-01 00:00:00

  • A new transtrochanteric approach to the hip.

    abstract::This transtrochanteric approach to the hip maintains continuity between the greater trochanter and the vastus lateralis muscle, thereby preventing the gross displacement of the greater trochanter and preserving the branches of the lateral circumflex vessels to it. The procedure offers the advantages of easy exposure a...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00265739

    authors: Lindgren U,Svenson O

    更新日期:1988-01-01 00:00:00

  • Outcomes after terrible triads of the elbow treated with the current surgical protocols. A review.

    abstract::Dislocation of the elbow associated with radial head and coronoid fracture, the so-called "terrible triad" of the elbow, is challenging to treat and has a history of complicated outcomes. However, advances in the knowledge of elbow kinematics combined with improved implants and surgical techniques during the past few ...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-010-1024-6

    authors: Rodriguez-Martin J,Pretell-Mazzini J,Andres-Esteban EM,Larrainzar-Garijo R

    更新日期:2011-06-01 00:00:00

  • Remission of secondary Raynaud phenomenon using intra-arterial prostaglandin E1 infusion. A case report.

    abstract::A man, aged 52 years, who had a secondary Raynaud phenomenon affecting the left hand and index finger had been treated unsuccessfully with intravenous prostaglandin E1 and amputation of the finger was proposed. He was given intra-arterial prostaglandin E1 for 10 days and amputation was not necessary. He recovered almo...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/BF00187085

    authors: Seemann J,Scholz J,Sielwicz M

    更新日期:1994-01-01 00:00:00

  • Manipulation under anaesthesia for frozen shoulder in patients with and without non-insulin dependent diabetes mellitus.

    abstract::Manipulation under anaesthesia (MUA) has been used to speed up recovery. However, the outcome of frozen shoulder after MUA in patients with diabetes has not been well documented in the past. A higher prevalence of frozen shoulder has been reported in diabetes mellitus (DM) patients. In this study, we revealed the shor...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-010-0968-x

    authors: Wang JP,Huang TF,Ma HL,Hung SC,Chen TH,Liu CL

    更新日期:2010-12-01 00:00:00

  • Bone morphogenetic protein and orthopaedic surgery: can we legitimate its off-label use?

    abstract:PURPOSE:Bone morphogenetic proteins (BMP) are recombinant osteoinductive proteins with their primary role being to promote bone formation. The off-label use of BMP in orthopaedic surgery has dramatically increased. However, reports of complications with BMP have emerged, and the safety of these proteins in orthopaedics...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-014-2534-4

    authors: Courvoisier A,Sailhan F,Laffenêtre O,Obert L,French Study Group of BMP in Orthopedic Surgery.

    更新日期:2014-12-01 00:00:00

  • Distraction osteogenesis with conventional external fixator for tibial bone loss.

    abstract::Between 1991 and 2002, we treated 21 patients with tibial bone loss using a conventional external fixator. Nine patients had an infected open fracture and 12 patients an infected nonunion. After corticotomy, the bone was distracted at the rate of 1 mm (1 mm/step) on alternate days or every 48 h. The mean follow-up per...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-004-0553-2

    authors: Sangkaew C

    更新日期:2004-06-01 00:00:00

  • Does computer-assisted total knee arthroplasty improve the overall component position and patient function?

    abstract:PURPOSE:There remains controversy as to whether computer-navigated total knee replacement (TKR) improves the overall prosthesis alignment and patient function. The aim of this study was to determine whether computer-assisted total knee arthroplasty provides superior prosthesis positioning when compared to a conventiona...

    journal_title:International orthopaedics

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00264-013-1996-0

    authors: Allen CL,Hooper GJ,Oram BJ,Wells JE

    更新日期:2014-02-01 00:00:00

  • Three-in-one protocol reduces mortality of patients with haemodynamically unstable pelvic fractures-a five year multi-centred review in Hong Kong.

    abstract:PURPOSE:The mortality rate in patients with haemodynamically unstable pelvic fractures is as high as 40-60%. Despite the new advances in trauma care which are in phase in trauma centres in Hong Kong, the management of haemodynamically unstable pelvic fracture is still heterogeneous. The aim of this study is to review t...

    journal_title:International orthopaedics

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00264-018-3842-x

    authors: Cheng M,Lee KY,Chang AL,Ho HF,Chan LS,Lee KB,Kwok PH,Lee AW,Wong KK,Kam CW,Leung GK,Wong JS,Cheung NK,Yeung JH,Tang N,Choi SH,Lau TW,Wong HT,Leung M

    更新日期:2018-10-01 00:00:00

  • Epiphysis preserving resection of malignant proximal tibial tumours.

    abstract:PURPOSE:The purpose of the study was to evaluate the treatment of five patients with proximal tibial epiphysis preserving resection for malignant tumours of the tibia. METHOD:Three patients suffered from Ewing sarcoma, two had osteosarcoma. The proximal level of the resection was in the line of the growth plate in fou...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-012-1731-2

    authors: Kiss S,Terebessy T,Szöke G,Kiss J,Antal I,Szendröi M

    更新日期:2013-01-01 00:00:00

  • Management of type 13C2 distal humerus fractures by olecranon osteotomy approach versus triceps sparing approach-our experience with sixty cases.

    abstract:BACKGROUND:Intercondylar humerus fractures (AO type 13C), though less common (less than 1%), are increasing over the last few years. Open reduction and internal fixation (ORIF) of these fractures are now well recognised and preferred management. These fractures are principally approached from posterior side and various...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-020-04785-6

    authors: Ansari MF,Khan NA,Atif AM

    更新日期:2020-12-01 00:00:00

  • What is a "periprosthetic shoulder infection"? A systematic review of two decades of publications.

    abstract:PURPOSE:While as many as 50% of revision shoulder arthroplasties are culture positive, a consistent, clinically useful definition of a "periprosthetic shoulder infection" is lacking. We conducted a systematic review of the published literature with respect to (1) the definition of a "periprosthetic shoulder infection",...

    journal_title:International orthopaedics

    pub_type: 杂志文章,评审

    doi:10.1007/s00264-017-3421-6

    authors: Hsu JE,Somerson JS,Vo KV,Matsen FA 3rd

    更新日期:2017-04-01 00:00:00

  • Short-term follow up after implantation of a cell-free collagen type I matrix for the treatment of large cartilage defects of the knee.

    abstract:PURPOSE:Although there are various new scaffold-based techniques for cartilage regeneration it remains unclear up to which defect size they can be used. The present study reports of a cell-free collagen type I gel matrix for the treatment of large cartilage defects of the knee after a two-year follow-up. METHODS:Twent...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-015-2695-9

    authors: Roessler PP,Pfister B,Gesslein M,Figiel J,Heyse TJ,Colcuc C,Lorbach O,Efe T,Schüttler KF

    更新日期:2015-12-01 00:00:00

  • Causes and preventive measures of symptomatic spinal epidural haematoma after spinal surgery.

    abstract:STUDY DESIGN:This was a retrospective study to evaluate clinical characteristics of patients who developed symptomatic spinal epidural haematoma (SSEH) after spinal surgery. OBJECTIVE:The objective was to determine clinical parameters associated with the development of SSEH after spinal surgery, and to discuss clinica...

    journal_title:International orthopaedics

    pub_type: 杂志文章

    doi:10.1007/s00264-017-3506-2

    authors: Zeng XJ,Wang W,Zhao Z,Li M

    更新日期:2017-07-01 00:00:00