Abstract:
INTRODUCTION:Fecal microbiota transplantation (FMT) is currently being explored as a potential therapy for ulcerative colitis (UC). Here, we report the first case of a UC patient with allergy to 5-aminosalicylic acid (5-ASA) who underwent FMT and achieved clinical remission. CASE PRESENTATION:This patient had a 9-year history of UC and was allergic to 5-ASA. He suffered from gradually aggravated abdominal pain and frequent bloody diarrhea. There was a continuous distribution of superficial erosion and ulceration by colonoscopy. After steroid therapy failed, he underwent FMT. The donated fecal microbes were purified in laboratory and then transplanted into the terminal ileum and right colon of the patient by colonoscopy. During the 9 months' follow-up, FMT has proved its efficacy in inducing and maintaining clinical and endoscopic remission of the patient. CONCLUSION:The choice of treatment for refractory UC patients who are allergic to 5-ASA is relatively limited. In our case, we highlight the specific role of FMT for refractory UC with absence of 5-ASA through intestinal microbiota reconstruction.
journal_name
Medicine (Baltimore)journal_title
Medicineauthors
Wang HG,Liu SP,Ma TH,Yan W,Zhou JF,Shi YT,Shen P,Yang XZ,Wu SNdoi
10.1097/MD.0000000000010675subject
Has Abstractpub_date
2018-05-01 00:00:00pages
e0675issue
19eissn
0025-7974issn
1536-5964pii
00005792-201805110-00029journal_volume
97pub_type
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