Coronavirus disease 2019-associated rapidly progressive organizing pneumonia with fibrotic feature: Two case reports.

Abstract:

INTRODUCTION:Pneumonia is one of the most important characteristics of coronavirus disease 2019 (COVID-19) and imaging findings of COVID-19 pneumonia are diverse and change over disease course. However, the detailed clinical course of organizing pneumonia (OP) caused by COVID-19 has not been clarified. PATIENT CONCERNS:A 60-year-old man and a 61-year-old woman diagnosed with mild COVID-19 were admitted to our hospital. Their respiratory symptoms were deteriorating even after initiating treatment with antiviral drugs. DIAGNOSIS:Chest X-rays and computed tomography scan showed a rapid progression of linear consolidation with reversed halo sign, distributed in subpleural and peri-bronchial regions. They also presented with pulmonary fibrosis findings, including traction bronchiectasis and marked lung volume reduction. They were diagnosed with rapidly progressing OP. INTERVENTIONS:They were treated with systemic corticosteroids. OUTCOMES:The patients' imaging findings and respiratory conditions improved rapidly without any adverse effects. CONCLUSION:Physicians should carefully monitor patients with COVID-19, as they can develop rapidly progressive and fibrotic OP, which respond to corticosteroids.

journal_name

Medicine (Baltimore)

journal_title

Medicine

authors

Okamori S,Lee H,Kondo Y,Akiyama Y,Kabata H,Kaneko Y,Ishii M,Hasegawa N,Fukunaga K

doi

10.1097/MD.0000000000021804

subject

Has Abstract

pub_date

2020-08-28 00:00:00

pages

e21804

issue

35

eissn

0025-7974

issn

1536-5964

pii

00005792-202008280-00043

journal_volume

99

pub_type

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