Abstract：
:Preterm infants often experience intermittent hypoxia (IH) with resolution in room air (RA) or hyperoxia (Hx) between events. Hypoxia is a major inducer of vascular endothelial growth factor, which plays a key role in normal and aberrant retinal angiogenesis. This study tested the hypothesis that neonatal IH which resolved with RA is less injurious to the immature retina than IH resolved by Hx between events. Newborn rats were exposed to: (1) Hx (50% O₂) with brief hypoxia (12% O₂); (2) RA with 12% O₂; (3) Hx with RA; (4) Hx only; or (5) RA only, from P0 to P14. Pups were examined at P14 or placed in RA until P21. Retinal vascular and astrocyte integrity; retinal layer thickness; ocular and systemic biomarkers of angiogenesis; and somatic growth were determined at P14 and P21. All IH paradigms resulted in significant retinal vascular defects, disturbances in retinal astrocyte template, retinal thickening, and photoreceptor damage concurrent with elevations in angiogenesis biomarkers. These data suggest that the susceptibility of the immature retina to changes in oxygen render no differences in the outcomes between RA or O₂ resolution. Interventions and initiatives to curtail O₂ variations should remain a high priority to prevent severe retinopathy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Beharry KD,Cai CL,Skelton J,Siddiqui F,D'Agrosa C,Calo J,Valencia GB,Aranda JVdoi
10.3390/ijms19051337subject
Has Abstractpub_date
2018-05-01 00:00:00issue
5issn
1422-0067pii
ijms19051337journal_volume
19pub_type
杂志文章abstract：:The introduction of Clearfield technology allows the use of imidazolinone (IMI) herbicides to control weedy rice. Imidazolinone herbicides stop the acetolactate synthase (ALS) enzyme from synthesizing branched-chain amino acids, resulting in the death of the plant. Since the launch of Clearfield technology in Malaysia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22030982
更新日期：2021-01-20 00:00:00
abstract：:Resveratrol stability in solution can be improved by combining the polyphenol with carboxymethylated (1,3/1,6)-β-d-glucan (CM-glucan), a carbohydrate polymer widely used in the food and pharmaceutical industries. The present work was undertaken to elucidate the mechanism behind this stabilizing effect. The supramolecu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18092006
更新日期：2017-09-19 00:00:00
abstract：:Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of S...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20082029
更新日期：2019-04-25 00:00:00
abstract：:Antibodies are composed of structurally and functionally independent domains that can be used as building blocks to construct different types of chimeric protein-format molecules. However, the generally used genetic fusion and chemical approaches restrict the types of structures that can be formed and do not give an i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030711
更新日期：2020-01-21 00:00:00
abstract：:Internal transcribed spacer region (ITS) sequencing is the most extensively used technology for accurate molecular identification of fungal pathogens in clinical microbiology laboratories. Intra-genomic ITS sequence heterogeneity, which makes fungal identification based on direct sequencing of PCR products difficult, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161025067
更新日期：2015-10-22 00:00:00
abstract：:We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12095844
更新日期：2011-01-01 00:00:00
abstract：:The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms20163991
更新日期：2019-08-16 00:00:00
abstract：:Polyester and/or polythioester grafted chitosan copolymers were synthesized. For that, poly(ε-caprolactone) (PCL), poly(ε-thiocaprolactone) (PTCL), and their copolymers were first synthesized by ring opening polymerization. Copolymers with caprolactone:thiocaprolactone (CL:TCL) molar ratios of 2:1, 1:1, 1:2 were synth...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123799
更新日期：2018-11-29 00:00:00
abstract：:The abnormal deposition of calcium within renal parenchyma, termed nephrocalcinosis, frequently occurs as a result of impaired renal calcium handling. It is closely associated with renal stone formation (nephrolithiasis) as elevated urinary calcium levels (hypercalciuria) are a key common pathological feature underlyi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21010369
更新日期：2020-01-06 00:00:00
abstract：:We prepared thermoresponsive hydrogels by mixing poly(N-isopropylacrylamide) (PNIPAAm) derivatives as the main chain components, octa-arm polyethylene glycol (PEG) as a crosslinker, and the Arg-Gly-Asp-Ser (RGDS) peptides as cell adhesion units. Human bone marrow-derived mesenchymal stem cells (hbmMSCs) were cultured ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041253
更新日期：2018-04-21 00:00:00
abstract：:Civilization diseases associated with memory disorders are important health problems occurring due to a prolonged life span. The manuscript shows the results of an in vivo study targeting the emergence of two drug candidates with anti-amnestic properties. The preceding quantitative structure-activity relationship (QSA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122511
更新日期：2017-11-24 00:00:00
abstract：:Recent proteome analyses have reported that intrinsically disordered regions (IDRs) of proteins play important roles in biological processes. In higher plants whose genomes have been sequenced, the correlation between IDRs and post-translational modifications (PTMs) has been reported. The genomes of various eukaryotic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160819812
更新日期：2015-08-20 00:00:00
abstract：:WRKY transcription factors constitute one of the largest transcription factor families in plants, and play crucial roles in plant growth and development, defense regulation and stress responses. However, knowledge about this family in maize is limited. In the present study, we identified a drought-induced WRKY gene, Z...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19103046
更新日期：2018-10-06 00:00:00
abstract：:Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Several lines of evidence have indicated a pathogenic role of insulin resistance, and a strong association with type 2 diabetes (T2MD) and metabolic syndrome. Importantly, NAFLD appears to enhance the risk for T2MD, as well as worse...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms141122933
更新日期：2013-11-20 00:00:00
abstract：:Naturally occurring cucurbitacins have been shown to have anticancer, antimicrobial and anti-inflammatory activities. In this study, we determined the effects of cucurbitacin B extracted from the Thai herb Trichosanthes cucumerina L. on telomerase regulation in three human breast cancer cell lines (T47D, SKBR-3, and M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11125323
更新日期：2010-01-01 00:00:00
abstract：:Microtubules are the main components of mitotic spindles, and are the pillars of the cellular cytoskeleton. They perform most of their cellular functions by virtue of their unique dynamic instability processes which alternate between polymerization and depolymerization phases. This in turn is driven by a precise balan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102042
更新日期：2017-09-22 00:00:00
abstract：:Substantial efforts are underway for prevention of early stages or recurrence of colorectal cancers (CRC) or new polyp formation by chemoprevention strategies. Several epidemiological, clinical and preclinical studies to date have supported the chemopreventive potentials of several targeted drug classes including non-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19082332
更新日期：2018-08-08 00:00:00
abstract：:Actomyosin-mediated contractility is required for the majority of force-driven cellular events such as cell division, adhesion, and migration. Under pathological conditions, the role of actomyosin contractility in malignant phenotypes of various solid tumors has been extensively discussed, but the pathophysiological r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103460
更新日期：2020-05-14 00:00:00
abstract：:Cholesteatoma is a destructive and expanding growth of keratinizing squamous epithelium in the middle ear or petrous apex. The molecular and cellular processes of the pathogenesis of acquired middle ear cholesteatoma have not been fully understood. In this study, comparative proteomic analysis was conducted to investi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140714439
更新日期：2013-07-11 00:00:00
abstract：:The temporomandibular joint (TMJ) is an articulation formed between the temporal bone and the mandibular condyle which is commonly affected. These affections are often so painful during fundamental oral activities that patients have lower quality of life. Limitations of therapeutics for severe TMJ diseases have led to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19020446
更新日期：2018-02-02 00:00:00
abstract：:A total of 85 strains of lactic acid bacteria were isolated from corn silage in this study and analyzed in vitro for their cholesterol removal, NPC1L1 protein down-regulation and bile salt deconjugation ability, respectively. Nineteen strains were selected for further analysis for their probiotic potential. Finally, 3...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092073
更新日期：2019-04-26 00:00:00
abstract：:The Duchenne muscular dystrophy (DMD) gene has a complex expression pattern regulated by multiple tissue-specific promoters and by alternative splicing (AS) of the resulting transcripts. Here, we used an RNAi-based approach coupled with DMD-targeted RNA-seq to identify RNA-binding proteins (RBPs) that regulate splicin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207803
更新日期：2020-10-21 00:00:00
abstract：:Jatropha curcas is a promising renewable feedstock for biodiesel and bio-jet fuel production. To study gene expression in Jatropha in different tissues throughout development and under stress conditions, we examined a total of 11 typical candidate reference genes using real-time quantitative polymerase chain reaction ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141224338
更新日期：2013-12-13 00:00:00
abstract：:The basic structural and functional unit of a living organism is a single cell. To understand the variability and to improve the biomedical requirement of a single cell, its analysis has become a key technique in biological and biomedical research. With a physical boundary of microchannels and microstructures, single ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160922319
更新日期：2015-09-15 00:00:00
abstract：:In the absence of lymphatics, fluid and solutes such as amyloid-β (Aβ) are eliminated from the brain along basement membranes in the walls of cerebral capillaries and arteries-the Intramural Peri-Arterial Drainage (IPAD) pathway. IPAD fails with age and insoluble Aβ is deposited as plaques in the brain and in IPAD pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041225
更新日期：2020-02-12 00:00:00
abstract：:Triazophos is a widely used organophosphorous insecticide that has potentially adverse effects to organisms. In the present study, a high-affinity single-chain variable fragment (scFv) antibody with specific lambda light chain was developed for residue monitoring. First, the specific variable regions were correctly am...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060823
更新日期：2016-06-07 00:00:00
abstract：:Deep eutectic solvents (DESs) are a potentially high-value lignin extraction methodology. DESs prepared from choline chloride (ChCl) and three hydrogen-bond donors (HBD)-lactic acid (Lac), glycerol, and urea-were evaluated for isolation of willow (Salix matsudana cv. Zhuliu) lignin. DESs types, mole ratio of ChCl to H...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112266
更新日期：2017-10-28 00:00:00
abstract：:Virus-like nanoparticles (VLNPs) have been studied extensively as nanocarriers for targeted drug delivery to cancer cells. However, VLNPs have intrinsic drawbacks, in particular, potential antigenicity and immunogenicity, which hamper their clinical applications. Thus, they can be eliminated easily and rapidly by host...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194903
更新日期：2019-10-03 00:00:00
abstract：:Activation of the cannabinoid CB1 receptor induces different cellular signaling cascades through coupling to different effector proteins (G-proteins and β-arrestins), triggering numerous therapeutic effects. Conformational changes and rearrangements at the intracellular domain of this GPCR receptor that accompany liga...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218111
更新日期：2020-10-30 00:00:00
abstract：:For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197104
更新日期：2020-09-26 00:00:00
