Advancements in the management of medically less-fit and older adults with newly diagnosed acute myeloid leukemia.

abstract：INTRODUCTION:The global epidemic of diabetes has led to an epidemic of diabetes complications. Diabetic neuropathy is the most common microvascular complication, of which diabetic peripheral neuropathy (DPN) and autonomic neuropathy (AN) are the most prevalent, affecting ~50% of patients. DPN results in pain with a poo...

journal_title：Expert opinion on pharmacotherapy

authors： Azmi S,Alam U,Burgess J,Malik RA

更新日期：2021-01-01 00:00:00

abstract：:Lapatinib is a dual (ErbB-1 and ErB-2) receptor tyrosine kinase inhibitor (TKI) that was recently approved by the FDA for the treatment of advanced breast cancer. It shows synergy with trastuzumab, and has demonstrated clinical activity in trastuzumab-resistant tumour. This paper reviews the drug development of lapati...

journal_title：Expert opinion on pharmacotherapy

authors： Mukherjee A,Dhadda AS,Shehata M,Chan S

更新日期：2007-09-01 00:00:00

abstract：:This editorial considers the use of the first selective oral renin inhibitor, aliskiren, in reducing angiotensin (Ang) II reactivation or aldosterone (ALDO) escape during renin-angiotensin-aldosterone system (RAAS) inhibition. RAAS blockade with angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin recep...

journal_title：Expert opinion on pharmacotherapy

authors： Athyros VG,Mikhailidis DP,Kakafika AI,Tziomalos K,Karagiannis A

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The skin and the brain interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly influence the initiation or flaring of skin disorders. OBJECTIVE:To obtain knowledge of these factors to assist in designing treatment plans for specific skin disorders. METHODS:Psychocutan...

journal_title：Expert opinion on pharmacotherapy

authors： Shenefelt PD

更新日期：2008-04-01 00:00:00

abstract：:Anticoagulants are used for the prevention and treatment of venous thromboembolism and for the secondary prevention of stroke and myocardial infarction. The list of available anticoagulants includes unfractionated heparin, low molecular weight heparins, fondaparinux, warfarin and the direct thrombin inhibitors. Numero...

journal_title：Expert opinion on pharmacotherapy

authors： Hawkins D,Huston SA

更新日期：2006-06-01 00:00:00

abstract：:Migraine is a common and disabling condition in children and adolescents. The complexity of migraine on a pathogenetic and clinical level results from the interaction between biological, psychological and environmental factors. Appropriate management requires an individually tailored strategy giving due consideration ...

journal_title：Expert opinion on pharmacotherapy

authors： Balottin U,Termine C

更新日期：2007-04-01 00:00:00

abstract：INTRODUCTION:The alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are the major mediators of glutamate-mediated excitatory neurotransmission, and are critical for synchronization and spread of epileptic activity. Areas covered: AMPA receptor antagonists have been also developed as antiepilepti...

journal_title：Expert opinion on pharmacotherapy

authors： Di Bonaventura C,Labate A,Maschio M,Meletti S,Russo E

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Only 40-60% of obsessive-compulsive patients respond to first line treatments, such as selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy. Several second-line treatments have been investigated in the last two decades, and most of them seem to work, at least in a subset of pati...

journal_title：Expert opinion on pharmacotherapy

authors： Grassi G,Pallanti S

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Short bowel syndrome (SBS) has traditionally been regarded as a rapidly fatal medical catastrophe. The advent of pharmacological options directly targeting disease pathophysiology justified this review. AREAS COVERED:Since the 1970s, home parenteral nutrition has reduced mortality, converting SBS into a c...

journal_title：Expert opinion on pharmacotherapy

authors： Hollanda Martins Da Rocha M,Lee ADW,Marin MLM,Faintuch S,Mishaly A,Faintuch J

更新日期：2020-04-01 00:00:00

abstract：:Diabetes mellitus is the most common cause of blindness among working-age adults, with a prevalence of 7 - 8% of adults in the USA, and is one of the most common causes of renal failure requiring kidney transplant and the most common cause of non-traumatic lower limb amputation in developed nations [1] . The role of t...

journal_title：Expert opinion on pharmacotherapy

authors： Danis RP,Sheetz MJ

更新日期：2009-12-01 00:00:00

abstract：INTRODUCTION:Diabetic foot ulcers, especially when they become infected, are a leading cause of morbidity and may lead to severe consequences, such as amputation. Optimal treatment of these diabetic foot problems usually requires a multidisciplinary approach, typically including wound debridement, pressure off-loading,...

journal_title：Expert opinion on pharmacotherapy

authors： Abbas M,Uçkay I,Lipsky BA

更新日期：2015-04-01 00:00:00

abstract：:Peglyated liposomal doxorubicin was developed to maintain or enhance the demonstrated antineoplastic effects of doxorubicin, while improving the toxicity profile associated with this important cytotoxic agent. Accumulating clinical data have confirmed the activity of pegylated liposomal doxorubicin in cancers of the b...

journal_title：Expert opinion on pharmacotherapy

authors： Markman M

更新日期：2006-08-01 00:00:00

abstract：INTRODUCTION:EGFR-targeted drugs have been successfully approved in many countries and have demonstrated higher efficacy and lower toxicity than chemotherapy in molecularly defined subgroups of patients. Significant advances in clinical trials and studies focusing on targeted therapies have rapidly developed in Asia. ...

journal_title：Expert opinion on pharmacotherapy

authors： Ke EE,Zhou Q,Wu YL

更新日期：2015-06-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Status epilepticus (SE) is a common neurological and medical emergency. It has high mortality and morbidity rates, which typically correlate with seizure semiology and duration; therefore, prompt and proper pharmacological intervention is paramount. In a pre-hospital setting, establishing venous access can...

journal_title：Expert opinion on pharmacotherapy

authors： Riva A,Iapadre G,Grasso EA,Balagura G,Striano P,Verrotti A

更新日期：2021-01-01 00:00:00

abstract：:Correct education of the patient is one of the most important aspects in the treatment of Tourette's syndrome. Pharmacotherapy is often unsatisfactory and therefore should be limited to those patients who are significantly impaired. Therapy must be individualised and the most troublesome symptom should be targeted fir...

journal_title：Expert opinion on pharmacotherapy

authors： Müller-Vahl KR

更新日期：2002-07-01 00:00:00

abstract：:Migraine is a multifactorial and disabling syndrome often in comorbidity with psychiatric illnesses. Triptans are the first-line treatment in acute attacks and the most effective drugs in various types of migraine. Sumatriptan was the first medication of this group. Thanks to multiple types of formulations that greatl...

journal_title：Expert opinion on pharmacotherapy

authors： Napoletano F,Lionetto L,Martelletti P

更新日期：2014-02-01 00:00:00

abstract：:Urinary tract infections (UTIs) are among the most commonly encountered bacterial infections. Acute uncomplicated UTIs in adults include episodes of cystitis and pyelonephritis. The main uropathogens causing uncomplicated UTIs have, in the past, been fairly predictable and they have generally been susceptible to sever...

journal_title：Expert opinion on pharmacotherapy

authors： Garrison J,Hooton TM

更新日期：2001-08-01 00:00:00

abstract：:Selective serotonin reuptake inhibitors (SSRIs) are now generally regarded as effective and better tolerated alternatives to tricyclic antidepressants (TCAs) for the treatment of depression. SSRIs also seem to be as well tolerated as moclobemide, mirtazapine, venlafaxine, reboxetine and nefazodone and show comparable ...

journal_title：Expert opinion on pharmacotherapy

authors： Mace S,Taylor D

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Incomplete remission and treatment resistance are common even in first-episode psychosis patients. OBJECTIVE:The aim of this review was to provide an overview of the available interventions and treatment pathways for the management of incomplete remission and treatment resistance in first-episode psychosis....

journal_title：Expert opinion on pharmacotherapy

authors： Lambert M,Naber D,Huber CG

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Management of a number of significant viral pathogens in transplant recipients remains challenging. OBJECTIVES:To define an optimal antiviral approach to the management of cytomegalovirus (CMV), human herpes virus-6 (HHV-6), Epstein-Barr (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), ...

journal_title：Expert opinion on pharmacotherapy

authors： Sun HY,Singh N

更新日期：2008-10-01 00:00:00

abstract：:One vaccine designed to prevent cancer by preventing a precursor infection is already in common use, and at least one more is in the latter stages of clinical development. These vaccines are part of a new era of cancer immunoprophylaxis. Several further vaccines are in preclinical and clinical development, targeted at...

journal_title：Expert opinion on pharmacotherapy

authors： Frazer I

更新日期：2004-12-01 00:00:00

abstract：:Actinic keratosis (AK) and basal cell carcinoma (BCC) are precancerous and cancerous skin lesions that should be treated especially when multiple or in cosmetically important areas. Apart from 5% 5-fluorouracil topical cream, which some feel is the gold standard topical treatment for AK, several invasive treatment mod...

journal_title：Expert opinion on pharmacotherapy

authors： Papadavid E,Stratigos AJ,Falagas ME

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Human respiratory syncytial virus (hRSV) is the primary viral cause of respiratory diseases, leading to bronchiolitis and pneumonia in vulnerable populations. The only current treatment against this virus is palliative, and no efficient and specific vaccine against this pathogen is available. AREAS COVERE...

journal_title：Expert opinion on pharmacotherapy

authors： Kalergis AM,Soto JA,Gálvez NMS,Andrade CA,Fernandez A,Bohmwald K,Bueno SM

更新日期：2020-12-01 00:00:00

abstract：INTRODUCTION:Despite intensified insulin treatment, many persons with type 1 diabetes (T1D) do not achieve glycemic and metabolic targets. Consequently, non-insulin chemical therapies that improve glycemic control and metabolic parameters without increasing the risk of adverse events (including hypoglycemia) are of int...

journal_title：Expert opinion on pharmacotherapy

authors： Frandsen CS,Dejgaard TF,Madsbad S,Holst JJ

更新日期：2018-06-01 00:00:00

abstract：:Diabetes mellitus is now occurring in epidemic proportions in many countries. Owing to the limited effectiveness of drug prophylaxis of diabetic complications after diabetes has developed, it may be more appropriate to investigate ways to prevent the onset of diabetes. A recent trial published by the Diabetes Preventi...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-07-01 00:00:00

abstract：:Recognising the value added by economic evaluations of clinical trials and the interaction of clinical, humanistic and economic end points, the Radiation Therapy Oncology Group (RTOG) has developed an Outcomes Model that guides the comprehensive assessment of this triad of end points. This paper will focus on the econ...

journal_title：Expert opinion on pharmacotherapy

authors： Konski A,Watkins-Bruner D,RTOG (Radiation Therapy Oncology Group) Outcomes Model.

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of sodium glucose co-transporter 2 inhibitors in non-obese compared with obese patients with type 2 diabetes mellitus is unknown. METHODS:We conducted post hoc analyses of the results of a 52-week open-label study of Japanese type 2 diabetes mellitus patients treated with 100 or 200 ...

journal_title：Expert opinion on pharmacotherapy

authors： Inagaki N,Goda M,Yokota S,Maruyama N,Iijima H

更新日期：2015-01-01 00:00:00

abstract：:Seasonal influenza causes significant morbidity and mortality in adults and children. However, a worldwide influenza pandemic could cause considerably more deaths (20-40 million) and would majorly disrupt everyday life in most countries. Oseltamivir has proven to be safe and effective for the prevention or treatment o...

journal_title：Expert opinion on pharmacotherapy

authors： Oxford J

更新日期：2005-11-01 00:00:00

abstract：:This article reviews the evidence supporting different somatic treatment strategies in the acute and maintenance treatment phases of bipolar disorder. Bipolar affective disorder is a chronic disorder with a life time incidence of 0.3 - 1.5/100 [1]. Severe affective disorder is associated with a risk of completed suici...

journal_title：Expert opinion on pharmacotherapy

authors： Watson S,Young AH

更新日期：2001-04-01 00:00:00