Intramuscular Midazolam for treatment of Status Epilepticus.

abstract：BACKGROUND:Tamoxifen is the established adjuvant treatment for postmenopausal women with hormone-sensitive breast cancer. OBJECTIVE:To determine whether the aromatase inhibitor anastrozole should replace tamoxifen as the adjuvant treatment in this cancer. METHODS:Two recent trials of anastrozole and tamoxifen as adju...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Acute pulmonary embolism (PE) is a life-threatening condition that has been treated with anticoagulation for almost 50 years. OBJECTIVES:To review the current treatment options for PE and discuss recently published new features. METHODS:We reviewed literature involving the treatment strategies for venous t...

journal_title：Expert opinion on pharmacotherapy

authors： Blondon M,Bounameaux H,Righini M

更新日期：2009-05-01 00:00:00

abstract：:The recently published Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) assessed the efficacy and safety of abaloparatide (80 µg daily subcutaneous) (ABL) vs placebo during 18 months, in postmenopausal osteoporosis. Teriparatide (20 µg daily subcutaneous) (TPD) was used as an open label active comparator...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri NM,Bruyere O

更新日期：2017-12-01 00:00:00

abstract：INTRODUCTION:Seizures or chronic epilepsy are a relatively common occurrence in a neurosurgical setting. However, seizure treatment after neurosurgery has received less attention compared with other causes and only few data are availaible in the literature on management in neurosurgical patients. Areas covered: This pa...

journal_title：Expert opinion on pharmacotherapy

authors： Ambrosi M,Orsini A,Verrotti A,Striano P

更新日期：2017-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Most guidelines suggest that failure of oral antidiabetic drugs should be followed by the addition of a basal insulin with aggressive titration of the dose. In most countries, neutral protamine Hagedorn (NPH)-insulin, glargine and detemir are the only choices. Clinical trials show that the metab...

journal_title：Expert opinion on pharmacotherapy

authors： Jensen MG,Hansen M,Brock B,Rungby J

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE:To revisit the various aspects of action of the drug in a dermatologic setting. METHOD:Review of the current peer-reviewed publications. RESULTS/CONCLUSION:Miconazole essentially inhibits 14alpha-demethylase, an enzyme requi...

journal_title：Expert opinion on pharmacotherapy

authors： Quatresooz P,Vroome V,Borgers M,Cauwenbergh G,Piérard GE

更新日期：2008-08-01 00:00:00

abstract：:The recently published results of the sequential treatment of postmenopausal osteoporotic women with subcutaneous abaloparatide (80 µg/day) (ABL) for 18 months followed by 6 months of oral alendronate (70 mg/week) (ALN) support the administration of an anti-resorptive agent after completion of a treatment course with ...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri N,Kaufman JM,Bruyère O

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Gastritis is a broad term, which is used for different conditions by clinicians, endoscopists and pathologists. Classification strategies have led to more congruence between specialists. The histological evaluation of the gastric mucosa is mandatory for diagnosing and classifying gastritis. Main aetiologic...

journal_title：Expert opinion on pharmacotherapy

authors： den Hollander WJ,Kuipers EJ

更新日期：2012-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Treatment options for metastatic colorectal cancer (mCRC) patients have rapidly increased in the past years, but 50 - 70% of mCRC patients are still unlikely to undergo radical resection of metastases and are candidates for palliative therapy only. AREAS COVERED IN THIS REVIEW:Oxaliplatin and i...

journal_title：Expert opinion on pharmacotherapy

authors： Fornaro L,Masi G,Loupakis F,Vasile E,Falcone A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The majority of patients with type 1 diabetes mellitus (T1DM) do not achieve glycemic targets. In addition, treatment with insulin is associated with increased risk for hypoglycemia and weight gain. Accordingly, there is an unmet need for new safe and effective glucose-lowering agents in this population. S...

journal_title：Expert opinion on pharmacotherapy

authors： Chatzopoulos G,Tziomalos K

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Paget's disease of the bone is a common condition in some populations, affecting almost 10% of older adults in western Europe. Though frequently asymptomatic, it can sometimes result in severe disabilities. Timely intervention is now able to arrest disease progression in the majority of patients. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Reid IR

更新日期：2012-04-01 00:00:00

abstract：:Venous thromboembolism is a frequent, life-threatening, postoperative complication of hip-fracture and total-knee-replacement surgery. Fondaparinux is a synthetic polysaccharide that selectively binds to antithrombin, the primary endogenous regulator of blood coagulation. Low molecular weight heparins, such as enoxapa...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-04-01 00:00:00

abstract：:ABSTARCT Introduction: Cardiovascular disease (CVD) continues to be an essential cause of morbidity and mortality among people living with human immunodeficiency virus infection (PLWH). Since the bulk of cardiovascular risk (CVR) factors are shared between PLWH and the general population, prevention and treatment stra...

journal_title：Expert opinion on pharmacotherapy

authors： Corbacho N,Mur I,Molas ME,Vidal F,Domingo P

更新日期：2021-01-04 00:00:00

abstract：:The orofacial complications of HIV infection are diverse, include opportunistic infection and malignancy and in many instances are region specific. Although effective management strategies to treat HIV-associated oral disease have been developed in North America and Europe, the evidence base on which these rely remain...

journal_title：Expert opinion on pharmacotherapy

authors： Hegarty AM,Chaudhry SI,Hodgson TA

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Olanzapine long-acting injection (OLAI), or olanzapine pamoate , is one of three second generation (SGA) antipsychotics now available in a long-acting formulation. OLAI is a microcrystalline salt of pamoic acid and olanzapine suspended in an aqueous solution that slowly dissociates into the separate compon...

journal_title：Expert opinion on pharmacotherapy

authors： Chue P,Chue J

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:Lysosomal storage disorders (LSDs) are clinically heterogeneous disorders that result primarily from lysosomal accumulation of macromolecules in various tissues. LSDs are always progressive, and often lead to severe symptoms and premature death. The identification of the underlying genetic and enzymatic de...

journal_title：Expert opinion on pharmacotherapy

authors： van Gelder CM,Vollebregt AA,Plug I,van der Ploeg AT,Reuser AJ

更新日期：2012-11-01 00:00:00

abstract：INTRODUCTION:Adjunctive pharmacotherapy is of key importance in determining the outcomes of percutaneous coronary intervention (PCI). In parallel, there has been an increasing body of evidence indicating that the aggressive management of coronary risk factors and changes in lifestyle behavior yield additional positive ...

journal_title：Expert opinion on pharmacotherapy

authors： Capodanno D,Tamburino C,Dangas G

更新日期：2011-05-01 00:00:00

abstract：:Staphylococcus aureus is a bacterial pathogen responsible for a variety of serious infections and is a frequent cause of nosocomial disease. During the last 60 years, S. aureus has developed increasing in vitro resistance to virtually all antimicrobials. In contrast, vancomycin has maintained a high degree of activity...

journal_title：Expert opinion on pharmacotherapy

authors： Pope SD,Roecker AM

更新日期：2007-06-01 00:00:00

abstract：:Gestational diabetes (GD) develops because pregnancy increases requirements for insulin secretion while increasing insulin resistance. Women with GD often have impaired pancreatic beta-cell compensation for insulin resistance. The nature of GD is currently contentious, with debate about its existence, diagnosis and ra...

journal_title：Expert opinion on pharmacotherapy

authors： Glueck CJ,Goldenberg N,Streicher P,Wang P

更新日期：2002-11-01 00:00:00

abstract：INTRODUCTION:Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease. AREAS COVERED:This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on barici...

journal_title：Expert opinion on pharmacotherapy

authors： Mendes JT,Balogh EA,Strowd LC,Feldman SR

更新日期：2020-06-01 00:00:00

abstract：:Diabetes mellitus is now occurring in epidemic proportions in many countries. Owing to the limited effectiveness of drug prophylaxis of diabetic complications after diabetes has developed, it may be more appropriate to investigate ways to prevent the onset of diabetes. A recent trial published by the Diabetes Preventi...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-07-01 00:00:00

abstract：:Recognising the value added by economic evaluations of clinical trials and the interaction of clinical, humanistic and economic end points, the Radiation Therapy Oncology Group (RTOG) has developed an Outcomes Model that guides the comprehensive assessment of this triad of end points. This paper will focus on the econ...

journal_title：Expert opinion on pharmacotherapy

authors： Konski A,Watkins-Bruner D,RTOG (Radiation Therapy Oncology Group) Outcomes Model.

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future. AREAS COVERED:Recent (post 2013) phase III clinical trials of schizophrenia-targeted the...

journal_title：Expert opinion on pharmacotherapy

authors： Garay RP,Citrome L,Samalin L,Liu CC,Thomsen MS,Correll CU,Hameg A,Llorca PM

更新日期：2016-01-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease. A...

journal_title：Expert opinion on pharmacotherapy

authors： Sumey C,Flaig TW

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Following more than 20 years of Interferon (IFN)-based treatment for hepatitis C virus (HCV), the understanding of viral life cycle led to the development of new antiviral drugs directly targeting HCV replication steps. Daclatasvir (DCV) is a potent inhibitor of non-structural NS5A HCV protein with pangeno...

journal_title：Expert opinion on pharmacotherapy

authors： Degasperi E,Aghemo A,Colombo M

更新日期：2015-01-01 00:00:00

abstract：:Synovitis is a painful and, occasionally, disabling disease. Patients with synovitis, especially new onset synovitis, should be referred to a rheumatologist urgently so that they can be assed and treated as quickly as possible. Clinical assessment and investigations are required to help differentiate between transient...

journal_title：Expert opinion on pharmacotherapy

authors： Sokoll KB,Helliwell P

更新日期：2006-01-01 00:00:00

abstract：INTRODUCTION:Parenteral support is lifesaving in short bowel syndrome patients with intestinal failure (SBS-IF), who are unable to compensate for their malabsorption by metabolic or pharmacologic adaptation. Mutually, the symptoms of SBS-IF and the inconveniences and complications in relation to parenteral support may ...

journal_title：Expert opinion on pharmacotherapy

authors： Nørholk LM,Holst JJ,Jeppesen PB

更新日期：2012-02-01 00:00:00

abstract：:Accumulating evidence suggests that HIV-infected individuals have an increased risk of cardiovascular events. This risk seems to be at least partially mediated by dyslipidaemia, which is related to the use of highly active antiretroviral therapy (HAART). As HIV-infected individuals live longer due to HAART, their card...

journal_title：Expert opinion on pharmacotherapy

authors： Manuel O,Thiébaut R,Darioli R,Tarr PE

更新日期：2005-08-01 00:00:00

abstract：:alpha-adrenoceptor antagonists have traditionally been used in the treatment of hypertension but in recent years they have become increasingly common in the treatment of benign prostatic enlargement (BPE), where they reduce the 'dynamic' component of bladder outlet obstruction and appear to have additional actions to ...

journal_title：Expert opinion on pharmacotherapy

authors： Chess-Williams R

更新日期：2002-02-01 00:00:00

abstract：:Phosphorus binders are used in patients with kidney failure because of the incomplete removal of phosphorus with dialysis and the inability to exclude phosphorus from the diet. Aluminium was the initial phosphorus binder used, but was replaced by calcium-containing binders because of the development of aluminium toxic...

journal_title：Expert opinion on pharmacotherapy

authors： Bleyer AJ

更新日期：2003-06-01 00:00:00