Effect of a sequential treatment combining abaloparatide and alendronate for the management of postmenopausal osteoporosis.

abstract：INTRODUCTION:Patisiran and inotersen are two therapies approved for the treatment of hereditary transthyretin-mediated (hATTR) amyloidosis with polyneuropathy, a rapidly progressive disease with a substantial clinical burden. This analysis indirectly compares the efficacy of patisiran and inotersen on neuropathy and qu...

journal_title：Expert opinion on pharmacotherapy

authors： Gorevic P,Franklin J,Chen J,Sajeev G,Wang JCH,Lin H

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION:Hydrochlorothiazide (HCTZ) has not been shown to reduce mortality or cardiovascular events when given as a single agent. In fact, HCTZ increased cardiovascular death and coronary artery disease (CAD) compared to placebo and usual care in 2 randomized trials, yet it is the most prescribed diuretic in the Un...

journal_title：Expert opinion on pharmacotherapy

authors： DiNicolantonio JJ

更新日期：2012-04-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Current therapy for Parkinson's disease (PD) is primarily directed at reversing the motor symptoms that are the consequence of dopamine deficiency and includes levodopa, dopamine agonists and monoamine oxidase (MAO) B inhibitors. New drugs offering both dopaminergic and non-dopaminergic actions ...

journal_title：Expert opinion on pharmacotherapy

authors： Schapira AH

更新日期：2010-09-01 00:00:00

abstract：INTRODUCTION:Advances in acute lymphocytic leukemia (ALL) therapy has led to long-term survival rates in children. However, only 30%-40% of adults achieve long-term disease-free survival. After relapse, the outcome of salvage chemotherapy is very disappointing with less than 10% of long survival. Novel agents are there...

journal_title：Expert opinion on pharmacotherapy

authors： Thomas X,Le Jeune C

更新日期：2016-12-01 00:00:00

abstract：:Initially it was considered that moxonidine, like clonidine, acted at central (2)-adrenoceptors to reduce blood pressure. With the characterisation of imidazoline binding sites distinct from (2)-adrenoceptors, the consensus became that moxonidine was acting predominantly at imidazoline I(1) receptors in the rostral ve...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2001-02-01 00:00:00

abstract：:Benign prostatic hyperplasia is a major men's health issue, with approximately 80% of all men developing this condition within their lifetime. A variety of oral treatments is available, including alpha-adrenoceptor antagonists (alpha-blockers), 5alpha reductase inhibitors, aromatase inhibitors and phytotherapy. A larg...

journal_title：Expert opinion on pharmacotherapy

authors： Khastgir J,Arya M,Shergill IS,Kalsi JS,Minhas S,Mundy AR

更新日期：2002-12-01 00:00:00

abstract：:Until recently, atorvastatin was known only as a new but more potent statin ('me too' drug) for lowering low-density lipoprotein cholesterol. In the last 2 years, data has become available on nearly 32,000 patients, in clinical settings ranging from primary prevention to acute coronary syndromes. These trials show the...

journal_title：Expert opinion on pharmacotherapy

authors： Ray KK,Cannon CP

更新日期：2005-06-01 00:00:00

abstract：:Pain may produce metabolic changes after surgery, which may contribute to further morbidity. A variety of medicines and techniques can be used to successfully treat pain. It is postulated that improved analgesia leads to improved outcomes, although analgesics may also contribute to morbidity. This article reviews the ...

journal_title：Expert opinion on pharmacotherapy

authors： Engoren M

更新日期：2003-09-01 00:00:00

abstract：:Almotriptan is a serotonin (5-hydroxytryptamine, 5HT)(1B/1D)-receptor agonist approved for the acute treatment of migraine. In 3500 acute migraine patients enrolled in short-term trials and 1500 patients in long-term open-label trials, almotriptan 12.5 mg was effective and well-tolerated. Almotriptan maintains a consi...

journal_title：Expert opinion on pharmacotherapy

authors： Dodick DW

更新日期：2003-07-01 00:00:00

abstract：INTRODUCTION:Lefamulin is a novel antibiotic that belongs to the pleuromutilin class with excellent activity against all microorganisms, including atypical pathogens, that cause community-acquired pneumonia (CAP). AREAS COVERED:This article reviews the spectrum of activity, the main pharmacokinetic and pharmacodynamic...

journal_title：Expert opinion on pharmacotherapy

authors： Falcó V,Burgos J,Almirante B

更新日期：2020-04-01 00:00:00

abstract：:The American Heart Association annual meeting must be one of the largest scientific gatherings, attracting over 30,000 delegates. The meeting at the end of last year was held in Atlanta, USA, the 2000 meeting will be in New Orleans, USA. The following highlights represent my own interests. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lunnon MW

更新日期：2000-03-01 00:00:00

abstract：:Following Huggins' original observation of the dependence of the prostate on androgens, testosterone suppression by either orchiectomy or oestrogen compounds (e.g., diethylstilbesterol [DES]) became the standard palliative treatment for advanced prostate cancer. Early studies showed testosterone suppression improved s...

journal_title：Expert opinion on pharmacotherapy

authors： Perez-Marrero R,Tyler RC

更新日期：2004-02-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Treatment options for metastatic colorectal cancer (mCRC) patients have rapidly increased in the past years, but 50 - 70% of mCRC patients are still unlikely to undergo radical resection of metastases and are candidates for palliative therapy only. AREAS COVERED IN THIS REVIEW:Oxaliplatin and i...

journal_title：Expert opinion on pharmacotherapy

authors： Fornaro L,Masi G,Loupakis F,Vasile E,Falcone A

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:With growing knowledge of the molecular pathway of carcinogenesis, targeted therapies have become the 'blue ocean' of cancer treatment. sorafenib is an oral multikinase inhibitor that targets Raf/mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase (ERK) (Raf/MEK/ERK) and several ty...

journal_title：Expert opinion on pharmacotherapy

authors： Woo HY,Heo J

更新日期：2012-05-01 00:00:00

abstract：:An increasing need for economic evaluations of non-Hodgkin's lymphoma (NHL) treatments exists. We performed a literature review on the currently available NHL economic evaluations, using PubMed and the Cochrane database. English and Dutch language papers on treatment in adults were selected. A total of 88 publications...

journal_title：Expert opinion on pharmacotherapy

authors： van Agthoven M,Uyl-de Groot CA,Sonneveld P,Hagenbeek A

更新日期：2004-12-01 00:00:00

abstract：:Autism is a heterogeneous condition, currently with no single explanation for all of these findings presented at this conference. What conferences like this offer us, however, are possible courses of new research and the subsequent development of intervention strategies, both orthodox (pharmacological) and perhaps sli...

journal_title：Expert opinion on pharmacotherapy

authors： Whiteley P

更新日期：2001-07-01 00:00:00

abstract：INTRODUCTION:Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with a highly variable clinical course. Frontline treatments include cytotoxic chemotherapies, immunotherapies, and small molecule inhibitors. Clinical and molecular factors guide treatment initiation and selection. Over the last decade,...

journal_title：Expert opinion on pharmacotherapy

authors： Samples LS,Graf SA

更新日期：2018-10-01 00:00:00

abstract：:One of the most significant advances of the last decade has been the development of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors. A large series of randomised, controlled clinical trials of these agents have shown a significant reduction in ischaemic events, not only in acute coronary syndrome patients, but...

journal_title：Expert opinion on pharmacotherapy

authors： Anne G,Gruberg L

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Panic disorder (PD) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks. PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide. PD should be treated effectively as soon as the symptoms emerge because the long...

journal_title：Expert opinion on pharmacotherapy

authors： Freire RC,Hallak JE,Crippa JA,Nardi AE

更新日期：2011-06-01 00:00:00

abstract：:The use of antihypertensive therapy is an evolving paradigm. Although blood pressure (BP) control rates remain low, there have been improvements that may be attributable in part to a recent shift in clinical guidelines that recognizes that most patients will require multiple drugs to reach BP goals and encourages clin...

journal_title：Expert opinion on pharmacotherapy

authors： Calhoun DA

更新日期：2009-08-01 00:00:00

abstract：:Despite the revolutionary introduction of antibiotic therapy in the post-World War II era, primary care physicians continue to struggle with the issue of optimal treatment strategies for bacterial infection and the growing problem of antimicrobial resistance. The aggressive use of potent agents as first-line therapy m...

journal_title：Expert opinion on pharmacotherapy

authors： Nicolau DP

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common immune-mediated disorder that in 70% of cases appears in mild or mild-to-moderate form. Psoriasis is usually treated with topical medications and/or phototherapy with variable efficacy in controlling the disease. AREAS COVERED:For the past three decades, research has been focused on ...

journal_title：Expert opinion on pharmacotherapy

authors： Chiricozzi A,Pitocco R,Saraceno R,Nistico SP,Giunta A,Chimenti S

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Breast cancer (BC) remains the most frequently diagnosed cancer and the most common cause of cancer death among women of all races worldwide. Over 80% of BC cases are hormone receptor (HR)-positive, comprised of luminal A and luminal B per molecular subtypes, imposing an urgent need to fully understand the...

journal_title：Expert opinion on pharmacotherapy

authors： Duso BA,Trapani D,Viale G,Criscitiello C,D'Amico P,Belli C,Mazzarella L,Locatelli M,Minchella I,Curigliano G

更新日期：2018-02-01 00:00:00

abstract：INTRODUCTION:Combination of glibenclamide (glyburide in the U.S.) and metformin hydrochloride simultaneously addresses two different but complimentary mechanisms to improve glycemic control in type 2 diabetes. AREAS COVERED:The pharmacokinetics, efficacy, and side effect profile of the oral combination of glibenclamid...

journal_title：Expert opinion on pharmacotherapy

authors： Lamos EM,Stein SA,Davis SN

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Breast cancer is a common, life-threatening disease among women. Contemporary hormonal therapy with third-generation aromatase inhibitors for estrogen-receptor-positive breast cancers in postmenopausal women is still facing the challenge of interpatient variability in therapeutic response and intensity of ...

journal_title：Expert opinion on pharmacotherapy

authors： Turkistani A,Marsh S

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Prescription omega-3-acid ethyl esters (P-OM3) have been used as adjunctive therapy to statin drugs in patients with mixed hyperlipidemia. OBJECTIVE:To assess the effect of concomitant administration of 4 g P-OM3 on the steady-state pharmacokinetics of the maximum recommended daily dose of atorvastatin (80 ...

journal_title：Expert opinion on pharmacotherapy

authors： Di Spirito M,Morelli G,Doyle RT,Johnson J,McKenney J

更新日期：2008-12-01 00:00:00

abstract：:The objective of this article is to evaluate the roles of the lipid-lowering class of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in reducing cardiovascular events and to review their mechanism of action based on in vitro and in vivo studies. The clinical outcome of 15 major clinical...

journal_title：Expert opinion on pharmacotherapy

authors： Moghadasian MH,Mancini GB,Frohlich JJ

更新日期：2000-05-01 00:00:00

abstract：:Genomic variations influencing response to pharmacotherapy of pain are under investigation. Candidate genes such as (opioid)-receptors, transporters and other molecules important for pharmacotherapy are discussed. Drug metabolising enzymes represent a further major target of ongoing research in order to identify assoc...

journal_title：Expert opinion on pharmacotherapy

authors： Stamer UM,Stüber F

更新日期：2007-10-01 00:00:00

abstract：:Neonatal herpes is a potentially devastating consequence of perinatal transmission of the herpes simplex virus (HSV), with significant morbidity and mortality. Treatment options are available, but must begin early in disease with manifestations that are often protean. Thus, preventive measures need to be optimised. An...

journal_title：Expert opinion on pharmacotherapy

authors： Leung DT,Sacks SL

更新日期：2003-10-01 00:00:00