Adjuvant medical therapy for prostate cancer.


IMPORTANCE OF THE FIELD:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease. AREAS COVERED IN THIS REVIEW:This article reviews the role of adjuvant treatment of non-metastatic prostate cancer. To identify all pertinent publications, a literature search of the National Library of Medicine (PubMed) from inception to 22 June 2010 was conducted for 'adjuvant prostate cancer', with these results filtered for clinical trials and systematic reviews. WHAT THE READER WILL GAIN:This work reviews the uses of adjuvant androgen deprivation therapy and chemotherapy for prostate cancer. There is a clear benefit from the use of androgen deprivation therapy in conjunction with radiation therapy for selected patients, but the role of postoperative chemotherapy is poorly defined. Identifying appropriate patients for adjuvant therapy continues to be a challenge. TAKE HOME MESSAGE:There is a complex literature describing the role of adjuvant medical therapy in prostate cancer, which is reviewed here. Continuing and future clinical trials will define the utility of adjuvant therapy in this setting and require the support of the clinical community.


Sumey C,Flaig TW




Has Abstract


2011-01-01 00:00:00












  • Starting aripiprazole long-acting-once-a-month early in treatment: why, how and for whom? Expert consensus and practical recommendations by a panel of Italian clinicians.

    abstract:INTRODUCTION:Aripiprazole long acting once-monthly (AOM) is approved for the treatment of schizophrenia in adults. Despite recent evidence of AOM efficacy in the acute treatment of schizophrenia, it is recommended that AOM should be started once the acute symptoms are controlled and patients are stabilized. However, th...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章


    authors: Amodeo G,Candiracci C,Capecci I,De Filippis S,Giuliani S,Guerani G,Tomasetti C,Villari V,Fagiolini A

    更新日期:2016-11-01 00:00:00

  • Olanzapine: a critical review of recent literature.

    abstract::The purpose of this review is to critically review the current literature on olanzapine with an emphasis on emergent themes and key findings in the use of this agent for the treatment of mood disorders and schizophrenia. New information continues to emerge on the impact of olanzapine on schizophrenia and on aspects of...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Buckley PF

    更新日期:2005-10-01 00:00:00

  • Apremilast as a treatment for psoriasis.

    abstract:INTRODUCTION:Psoriasis is a common skin disorder characterized by chronic inflammatory lesions that are frequently vexing for patients and difficult for physicians to treat. Although multiple therapeutic options are available, all have limitations. Topical preparations have issues with patient adherence, as compared to...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Shutty B,West C,Pellerin M,Feldman S

    更新日期:2012-08-01 00:00:00

  • Emerging therapies for ionizing radiation-associated skin field carcinogenesis.

    abstract:BACKGROUND:Radiodermatitis in its acute and chronic presentations represents a set of specific adverse effects resulting from ionizing radiations. Skin-field cancerization is another condition associated to or independent of clinically recognizable radiodermatitis. This condition leads to the risk of later occurrence o...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Piérard GE,Piérard-Franchimont C,Paquet P,Quatresooz P

    更新日期:2009-04-01 00:00:00

  • Enhancing intracellular taxane delivery: current role and perspectives of nanoparticle albumin-bound paclitaxel in the treatment of advanced breast cancer.

    abstract:INTRODUCTION:Docetaxel and paclitaxel are among the most active agents for the treatment of breast cancer. These first-generation taxanes are extremely hydrophobic; therefore, solvents are needed for its parenteral administration. Albumin nanoparticle technology allows for the transportation of such hydrophobic drugs w...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Guarneri V,Dieci MV,Conte P

    更新日期:2012-02-01 00:00:00

  • Safety and efficacy of canagliflozin in Japanese patients with type 2 diabetes mellitus: post hoc subgroup analyses according to body mass index in a 52-week open-label study.

    abstract:BACKGROUND:The safety and efficacy of sodium glucose co-transporter 2 inhibitors in non-obese compared with obese patients with type 2 diabetes mellitus is unknown. METHODS:We conducted post hoc analyses of the results of a 52-week open-label study of Japanese type 2 diabetes mellitus patients treated with 100 or 200 ...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Inagaki N,Goda M,Yokota S,Maruyama N,Iijima H

    更新日期:2015-01-01 00:00:00

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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Quigley EM,Neshatian L

    更新日期:2016-01-01 00:00:00

  • Current and emerging drug treatment strategies for peripheral arterial disease.

    abstract:INTRODUCTION:Peripheral artery disease (PAD) is a prevalent but underdiagnosed manifestation of atherosclerosis that has a worse prognosis than coronary artery disease. Patients with PAD are at heightened risk of both systemic cardiovascular adverse events and limb-related morbidity. There is insufficient awareness of ...

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    authors: Essa H,Torella F,Lip GYH

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  • Adjunctive strategies in the treatment of refractory bipolar depression: clinician options in the absence of a systematic database.

    abstract::Multiple approaches to enhancing antidepressant treatment response in bipolar depression are available and should, in many instances, be explored despite a lack of definitive controlled trial literature supporting their efficacy. Given that the morbidity of depression is three times greater than mania in bipolar illne...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Post RM

    更新日期:2005-04-01 00:00:00

  • Can binimetinib, encorafenib and masitinib be more efficacious than currently available mutation-based targeted therapies for melanoma treatment?

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    pub_type: 杂志文章,评审


    authors: Turner MC,Rossfeld K,Salama AK,Tyler D,Beasley G

    更新日期:2017-04-01 00:00:00

  • Recent advances in the medical therapy of Crohn's disease in childhood.

    abstract::Crohn's disease (CrD) is characterised by an ongoing inflammatory response in the gut, in the absence of an obvious trigger. The treatment of CrD in children, during relapse and remission, requires special consideration of growth and development. This review addresses the use of present medical management strategies, ...

    journal_title:Expert opinion on pharmacotherapy

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    authors: Bremner AR,Beattie RM

    更新日期:2007-10-01 00:00:00

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    authors: Chiricozzi A,Pitocco R,Saraceno R,Nistico SP,Giunta A,Chimenti S

    更新日期:2014-03-01 00:00:00

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    abstract:INTRODUCTION:Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD). The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy. When treating patients with obesity and CVD, certain medications may be more appropriate than others. AREAS COVE...

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    authors: Falcó V,Burgos J,Almirante B

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  • Erectile dysfunction, cardiovascular diseases and depression: interaction of therapy.

    abstract::Several studies have revealed the intimate associations between erectile dysfunction (ED), ischemic heart disease (IHD) and depression. Whether the physicians should also screen for the other two components when a patient presents with one component of this triad is still an important question to be answered. These th...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: El-Sakka AI,Shamloul R,Yassin AA

    更新日期:2009-09-01 00:00:00

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    abstract::Symptomatic and asymptomatic peripheral arterial occlusive disease (PAD) is indicative of widespread atherosclerosis. The major threat is from cardiovascular ischaemic events; thus, an important therapeutic goal is to modify atherosclerotic risk factors. Data from several large drug trials indicate that patients with ...

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    pub_type: 杂志文章,评审


    authors: Baumgartner I

    更新日期:2005-10-01 00:00:00

  • Emerging treatment using tubulin inhibitors in advanced non-small cell lung cancer.

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    pub_type: 杂志文章,评审


    authors: Hardin C,Shum E,Singh AP,Perez-Soler R,Cheng H

    更新日期:2017-05-01 00:00:00

  • Risperidone long-acting injection as monotherapy and adjunctive therapy in the maintenance treatment of bipolar I disorder.

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    pub_type: 杂志文章,评审


    authors: Fagiolini A,Casamassima F,Mostacciuolo W,Forgione R,Goracci A,Goldstein BI

    更新日期:2010-07-01 00:00:00

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    pub_type: 杂志文章,评审


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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章


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    abstract:INTRODUCTION:Since the recognition of inherited sodium (Na(+)) channel disease, the cardiac Na(+) channel has been extensively studied. Both loss-of-function and gain-of-function mutations of the cardiac Na(+) channel are associated with cardiac arrhythmia and sudden cardiac death. Pathophysiological mechanisms that ma...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: van Hoeijen DA,Blom MT,Tan HL

    更新日期:2014-09-01 00:00:00

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    abstract::alpha-adrenoceptor antagonists have traditionally been used in the treatment of hypertension but in recent years they have become increasingly common in the treatment of benign prostatic enlargement (BPE), where they reduce the 'dynamic' component of bladder outlet obstruction and appear to have additional actions to ...

    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Chess-Williams R

    更新日期:2002-02-01 00:00:00

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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章


    authors: Gorevic P,Franklin J,Chen J,Sajeev G,Wang JCH,Lin H

    更新日期:2021-01-01 00:00:00

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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Moroni G,Ponticelli C

    更新日期:2017-02-01 00:00:00

  • Abacavir/lamividune combination in the treatment of HIV-1 infection: a review.

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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Waters L,Moyle G

    更新日期:2006-12-01 00:00:00

  • Latest treatment strategies for membranous nephropathy.

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    journal_title:Expert opinion on pharmacotherapy

    pub_type: 杂志文章,评审


    authors: Ruggenenti P,Cravedi P,Remuzzi G

    更新日期:2007-12-01 00:00:00