Vinflunine for the treatment of breast cancer.

abstract：OBJECTIVE:To explore the treatment response, tolerability and safety of once-monthly paliperidone palmitate (PP1M) in non-acute patients switched from oral antipsychotics, stratified by time since diagnosis as recently diagnosed (≤3 years) or chronic patients (>3 years). RESEARCH DESIGN AND METHODS:Post hoc analysis o...

journal_title：Expert opinion on pharmacotherapy

authors： Hargarter L,Bergmans P,Cherubin P,Keim S,Conca A,Serrano-Blanco A,Bitter I,Bilanakis N,Schreiner A

更新日期：2016-06-01 00:00:00

abstract：INTRODUCTION:Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carb...

journal_title：Expert opinion on pharmacotherapy

authors： Wu G,Cheon E

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Multiple myeloma is a disease predominately affecting older adults. Pivotal to treating older adults is understanding their physiologic differences compared to younger subjects and how the complexity of therapies has an impact upon this patient population. AREAS COVERED:Herein, the authors address the eff...

journal_title：Expert opinion on pharmacotherapy

authors： Dempsey JL,Johns A,Rosko AE,Lazarus HM

更新日期：2019-05-01 00:00:00

abstract：:Orlistat (Xenical, Hoffmann-La Roche) is a powerful inhibitor of gastrointestinal lipase and as such, reduces fat absorption. Unlike other weight-reducing drugs it is minimally absorbed and has no effects in the CNS. Orlistat is indicated for patients with a body mass index (BMI) of at least 30 kg/m2 or 28 kg/m2 in th...

journal_title：Expert opinion on pharmacotherapy

authors： Ballinger A

更新日期：2000-05-01 00:00:00

abstract：:Seasonal influenza causes significant morbidity and mortality in adults and children. However, a worldwide influenza pandemic could cause considerably more deaths (20-40 million) and would majorly disrupt everyday life in most countries. Oseltamivir has proven to be safe and effective for the prevention or treatment o...

journal_title：Expert opinion on pharmacotherapy

authors： Oxford J

更新日期：2005-11-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:It is very rare for patients with bipolar disorder to have a single episode of mania or depression over a lifetime and the vast majority of these individuals need long-term prophylactic/maintenance treatment. However, treatment nonadherence is a major issue for close to half of subjects with bip...

journal_title：Expert opinion on pharmacotherapy

authors： Fagiolini A,Casamassima F,Mostacciuolo W,Forgione R,Goracci A,Goldstein BI

更新日期：2010-07-01 00:00:00

abstract：:A systemic and endemic emerging mycosis in Latin America, paracoccidioidomycosis, is characterised by its chronicity and by the severity of the disseminated form in healthy individuals, as well as in immunocompromised individuals co-infected with HIV, resulting, in the latter, in a mortality rate in the range of 30 - ...

journal_title：Expert opinion on pharmacotherapy

authors： Yasuda MA

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to analyze and compare the efficacy outcomes associated with the fentanyl iontophoretic transdermal system (ITS) and morphine intravenous (IV) patient-controlled analgesia (PCA) in the management of postoperative pain. RESEARCH DESIGN AND METHODS:This meta-analysis assessed t...

journal_title：Expert opinion on pharmacotherapy

authors： Sinatra RS,Viscusi ER,Ding L,Danesi H,Jones JB,Grond S

更新日期：2015-01-01 00:00:00

abstract：:Alcoholism is the third leading cause of preventable mortality and morbidity in the US. In the COMBINE (Combined Pharmacotherapies and Behavioural Interventions) study, the co-primary end points were the percentage of days abstinent and the time to first heavy drinking day after 16 weeks, and 1 year. The biggest diffe...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2006-10-01 00:00:00

abstract：:Correct education of the patient is one of the most important aspects in the treatment of Tourette's syndrome. Pharmacotherapy is often unsatisfactory and therefore should be limited to those patients who are significantly impaired. Therapy must be individualised and the most troublesome symptom should be targeted fir...

journal_title：Expert opinion on pharmacotherapy

authors： Müller-Vahl KR

更新日期：2002-07-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACE-Is) are an evidence-based treatment for patients who after myocardial infarction (MI) present with either heart failure (HF) or left ventricular systolic dysfunction, or both. An alternative could be a more complete inhibition of the renin-angiotensin system through the bl...

journal_title：Expert opinion on pharmacotherapy

authors： Maggioni AP,Fabbri G

更新日期：2005-03-01 00:00:00

abstract：:The recently published results of the sequential treatment of postmenopausal osteoporotic women with subcutaneous abaloparatide (80 µg/day) (ABL) for 18 months followed by 6 months of oral alendronate (70 mg/week) (ALN) support the administration of an anti-resorptive agent after completion of a treatment course with ...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri N,Kaufman JM,Bruyère O

更新日期：2018-02-01 00:00:00

abstract：:Everolimus is a novel immunosuppressive agent related to sirolimus. It is a proliferation signal inhibitor with an improved pharmacokinetic profile and bioavailability compared with sirolimus. Everolimus has been shown to be as effective as mycophenolate mofetil in reducing acute rejection in renal transplantation. In...

journal_title：Expert opinion on pharmacotherapy

authors： Patel JK,Kobashigawa JA

更新日期：2006-07-01 00:00:00

abstract：:Introduction: Ventricular arrhythmias are often seen in association with structural heart disease. However, approximately a tenth of affected patients have apparently normal hearts, where such arrhythmias typically occur in young patients, are sometimes inherited and can occasionally lead to sudden cardiac death (SCD)...

journal_title：Expert opinion on pharmacotherapy

authors： Ortmans S,Daval C,Aguilar M,Compagno P,Cadrin-Tourigny J,Dyrda K,Rivard L,Tadros R

更新日期：2019-12-01 00:00:00

abstract：:Management of patients undergoing cardiac surgery has evolved in recent years as more is understood about the physiological changes and responses that occur during and after cardiopulmonary bypass (CPB). In particular, our understanding of the mechanisms involved in haemostasis and in the inflammatory response to bypa...

journal_title：Expert opinion on pharmacotherapy

authors： Punjabi PP,Wyse RK,Taylor KM

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Obesity has become a global epidemic with recent estimates of > 400 million obese adults. Despite this, there are few safe and effective pharmacological interventions for obesity. Sibutramine is a weight loss agent, for use as an adjuvant to a comprehensive program of calorie restriction, exercise and behavi...

journal_title：Expert opinion on pharmacotherapy

authors： Sharma B,Henderson DC

更新日期：2008-08-01 00:00:00

abstract：:Osteosarcoma is the most frequent primary cancer of bone. When treated by surgery alone, it is almost invariably followed by metastatic dissemination and death. This dismal prognosis can be improved dramatically by including chemotherapy in an interdisciplinary regimen. Today, two-thirds of patients with localised ext...

journal_title：Expert opinion on pharmacotherapy

authors： Bielack SS,Machatschek JN,Flege S,Jürgens H

更新日期：2004-06-01 00:00:00

abstract：:Diabetes mellitus is the most common cause of blindness among working-age adults, with a prevalence of 7 - 8% of adults in the USA, and is one of the most common causes of renal failure requiring kidney transplant and the most common cause of non-traumatic lower limb amputation in developed nations [1] . The role of t...

journal_title：Expert opinion on pharmacotherapy

authors： Danis RP,Sheetz MJ

更新日期：2009-12-01 00:00:00

abstract：:Introduction: Liposarcomas are a heterogeneous group of soft tissue tumors that arise from adipose tissue and are one of the most common soft tissue sarcomas found in adults. Liposarcomas are subclassified into four subtypes with distinct histologic and biologic features that influence their treatment and management. ...

journal_title：Expert opinion on pharmacotherapy

authors： Suarez-Kelly LP,Baldi GG,Gronchi A

更新日期：2019-08-01 00:00:00

abstract：INTRODUCTION:Glioblastoma, the most common malignant brain tumor, exhibits a poor prognosis with little therapeutic progress in the last decade. Novel treatment strategies beyond the established standard of care with temozolomide-based radiotherapy are urgently needed. AREAS COVERED:We reviewed the literature on gliob...

journal_title：Expert opinion on pharmacotherapy

authors： Seystahl K,Gramatzki D,Roth P,Weller M

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Reduced injection force is among the modifications to the Next Generation FlexPen (NGFP). This force was compared with two other prefilled pens: SoloStar (SS) and KwikPen (KP). RESEARCH DESIGN/METHODS:The injection force of the pens was measured, with either a BD Micro-Fine 31G thin-wall needle, or a NovoFin...

journal_title：Expert opinion on pharmacotherapy

authors： Asakura T,Seino H,Kageyama M,Yohkoh N

更新日期：2009-06-01 00:00:00

abstract：:A number of medicine selection methods have been used worldwide for formulary purposes. In Northern Ireland, integrated medicines management is being developed, and related projects have been carried out. This paper deals with the description of the STEPS (Safe Therapeutic Economic Pharmaceutical Selection) programme....

journal_title：Expert opinion on pharmacotherapy

authors： Scott M,Timoney M,Mairs J,Crealey G,Al Abaddi I,Brenninkmeijer R,Janknegt R,McElnay J

更新日期：2007-10-01 00:00:00

abstract：:The Ras-Raf-MEK-ERK pathway is a ubiquitously expressed signalling module that regulates the proliferation, differentiation and survival of cells. This pathway features several oncogenes and is deregulated in approximately 30% of all human cancers. Thus, it has emerged as a prime target for antitumour therapy. Drugs t...

journal_title：Expert opinion on pharmacotherapy

authors： Kolch W

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:Incomplete remission and treatment resistance are common even in first-episode psychosis patients. OBJECTIVE:The aim of this review was to provide an overview of the available interventions and treatment pathways for the management of incomplete remission and treatment resistance in first-episode psychosis....

journal_title：Expert opinion on pharmacotherapy

authors： Lambert M,Naber D,Huber CG

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Ziconotide is an N-type calcium channel antagonist to treat chronic pain that is delivered intrathecally. It is the only intrathecal, FDA-approved, non-opioid analgesic and is recommended as first-line therapy. Despite these advantages, a small therapeutic window limits ziconotide's clinical utility, with ...

journal_title：Expert opinion on pharmacotherapy

authors： Pope JE,Deer TR

更新日期：2013-05-01 00:00:00

abstract：:Erectile dysfunction (ED) has serious negative consequences on both sexual experience and emotional well being and affects a broad range of age groups. The prevalence of ED is associated with increasing age and has been reported to be as high as 70%. Although the disorder is common and underdiagnosed, its treatment ca...

journal_title：Expert opinion on pharmacotherapy

authors： Becher E

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:Bipolar disorder is characterized by mood instability, which can be challenging to manage. First-line pharmacological approaches usually involve lithium, anticonvulsants and antipsychotics. Over the past fifteen years, several second-generation antipsychotics have demonstrated benefits for various phases o...

journal_title：Expert opinion on pharmacotherapy

authors： Janicak PG,Rado JT

更新日期：2012-08-01 00:00:00

abstract：:This paper describes the functional roles of the closely related pharmacogenetic and pharmacogenomic sciences in medicine. Firstly, they provide means for a better understanding of the function of drugs, and particularly of the differences of drug action between individuals and also between racially categorised popula...

journal_title：Expert opinion on pharmacotherapy

authors： Kalow W

更新日期：2005-07-01 00:00:00

abstract：INTRODUCTION:For more than two decades, lowering levels of low-density lipoprotein cholesterol has formed the cornerstone of management of patients with atherosclerotic cardiovascular disease. The substantial residual risk of clinical events in patients treated with statin therapy highlights the need to develop more ef...

journal_title：Expert opinion on pharmacotherapy

authors： Nicholls SJ,Pisaniello AD,Kataoka Y,Puri R

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:Treatment of complicated intra-abdominal infections (cIAIs) is becoming increasingly difficult because of the widespread emergence of multidrug-resistant organisms. AREAS COVERED:In this review, we discuss the effectiveness of several new antibiotics for the treatment of cIAIs, including new β-lactamase i...

journal_title：Expert opinion on pharmacotherapy

authors： Lin SY,Huang CH,Ko WC,Chen YH,Hsueh PR

更新日期：2016-01-01 00:00:00