Efficacy and safety of triple combination therapy for treating chronic obstructive pulmonary disease: an expert review.

abstract：INTRODUCTION:: Despite treatment with antipsychotic medication, approximately 1/3 of individuals with schizophrenia will fail to have an adequate response. To treat these patients, a commonly utilized approach is antipsychotic combination therapy. Antipsychotic combination therapy is controversial with mixed efficacy a...

journal_title：Expert opinion on pharmacotherapy

authors： Faden J,Kiryankova-Dalseth N,Barghini R,Citrome L

更新日期：2020-11-30 00:00:00

abstract：IMPORTANCE OF THE FIELD:Treatment options for metastatic colorectal cancer (mCRC) patients have rapidly increased in the past years, but 50 - 70% of mCRC patients are still unlikely to undergo radical resection of metastases and are candidates for palliative therapy only. AREAS COVERED IN THIS REVIEW:Oxaliplatin and i...

journal_title：Expert opinion on pharmacotherapy

authors： Fornaro L,Masi G,Loupakis F,Vasile E,Falcone A

更新日期：2010-01-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a progressive, life-threatening condition. Sitaxsentan, a selective endothelin-A receptor antagonist, is an effective, safe and well-tolerated endothelin receptor antagonist for the treatment of PAH in adult patients. Multi-center, randomized, placebo-controlled clinical trials...

journal_title：Expert opinion on pharmacotherapy

authors： Barst RJ

更新日期：2007-01-01 00:00:00

abstract：:There is considerable controversy over the level of evidence from randomized trials underpinning management decisions for patients presenting with localized cancer of the esophagus and esophago-gastric junction. There is also an optimism that new drugs and new approaches, including response prediction based on sequent...

journal_title：Expert opinion on pharmacotherapy

authors： Murphy TJ,Ravi N,Reynolds JV

更新日期：2008-12-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Diabetes mellitus is the most common endocrine disease in childhood. The global incidence of diabetes emphasizes the health, social and financial magnitude of this disease and the importance of optimizing disease management and prevention. AREAS COVERED IN THIS REVIEW:This article reviews the t...

journal_title：Expert opinion on pharmacotherapy

authors： Verrotti A,Chiuri RM,Blasetti A,Mohn A,Chiarelli F

更新日期：2010-10-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Mifepristone is a synthetic selective progesterone-receptor modulator (SPRM) that is widely used around the globe in the field of reproductive medicine. At present mifepristone is approved in a number of countries for early termination of pregnancy (TOP), cervical dilatation before surgical TOP,...

journal_title：Expert opinion on pharmacotherapy

authors： Im A,Appleman LJ

更新日期：2010-02-01 00:00:00

abstract：:Pain may produce metabolic changes after surgery, which may contribute to further morbidity. A variety of medicines and techniques can be used to successfully treat pain. It is postulated that improved analgesia leads to improved outcomes, although analgesics may also contribute to morbidity. This article reviews the ...

journal_title：Expert opinion on pharmacotherapy

authors： Engoren M

更新日期：2003-09-01 00:00:00

abstract：INTRODUCTION:Increasing population age, obesity and physical inactivity mean that type 2 diabetes mellitus (T2DM) is increasingly common. Current treatments may be limited by adverse events, drug-drug interactions or contraindication/need for dose adjustment in patients with renal impairment. AREAS COVERED:This paper ...

journal_title：Expert opinion on pharmacotherapy

authors： Forst T,Pfützner A

更新日期：2012-01-01 00:00:00

abstract：:There has been a significant increase in the number of cases of skin cancer diagnosed in the US in the past few years. Thus, it seems appropriate to review the available compounds that might be used in the chemoprevention of these lesions. This review focuses on the retinoids and details their results in clinical tria...

journal_title：Expert opinion on pharmacotherapy

authors： Niles RM

更新日期：2002-03-01 00:00:00

abstract：INTRODUCTION:Clostridium difficile infection (CDI) has become a significant healthcare-associated infection and is strongly associated with antibiotic use. Practice guidelines have recently been revised incorporating updated recommendations for diagnosis, treatment, and prevention. AREAS COVERED:This review discusses ...

journal_title：Expert opinion on pharmacotherapy

authors： Daniels LM,Kufel WD

更新日期：2018-11-01 00:00:00

abstract：INTRODUCTION:Myoclonic seizures are brief, involuntary muscular jerks arising from the central nervous system that can occur in different epilepsy syndromes, including idiopathic generalized epilepsies or the most severe group of epileptic encephalopathies. Valproate is commonly the first choice alone or in combination...

journal_title：Expert opinion on pharmacotherapy

authors： Striano P,Belcastro V

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Loss of bone mineral density is an emerging problem in persons living with HIV infection. Earlier and more rapid bone demineralization has been attributed not only to the high prevalence of traditional risk factors, but also to specific HIV-related factors. The aim of this guidance is to stimulate an appro...

journal_title：Expert opinion on pharmacotherapy

authors： Negredo E,Bonjoch A,Clotet B

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of daily sildenafil on levels of soluble molecular markers of endothelial function in men with erectile dysfunction. METHODS:Patients aged >18 years with erectile dysfunction of vascular etiology for >6 months, either alone or in combination with disease states strongly associated w...

journal_title：Expert opinion on pharmacotherapy

authors： Konstantinopoulos A,Giannitsas K,Athanasopoulos A,Spathas D,Perimenis P

更新日期：2009-02-01 00:00:00

abstract：:Chronic refractory angina is a term used to describe patients who, despite optimal medical therapy, have both angina and objective evidence of ischaemia. It is estimated that 5-15% of the 12 million patients with chronic angina in the US meet the criteria for having refractory angina. This review focuses on the follow...

journal_title：Expert opinion on pharmacotherapy

authors： Yang EH,Barsness GW

更新日期：2006-02-01 00:00:00

abstract：INTRODUCTION:Chronic constipation is a global problem affecting all ages and associated with considerable morbidity and significant financial burden for society. Though formerly defined on the basis of a single symptom, infrequent defecation; constipation is now viewed as a syndrome encompassing several complaints such...

journal_title：Expert opinion on pharmacotherapy

authors： Quigley EM,Neshatian L

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Epileptic emergencies are frequently encountered and include ictal events as status epilepticus or seizure clusters, and non-ictal situations like postictal psychosis or acute drug side effects. The aim of this review was to describe recent pharmacological advances in the treatment of epileptic emergencies...

journal_title：Expert opinion on pharmacotherapy

authors： Zelano J,Ben-Menachem E

更新日期：2016-11-01 00:00:00

abstract：:Anorexia is a frequent complication of uraemic syndrome, which contributes to malnutrition in dialysis patients. Uraemic anorexia has been associated with many factors. This paper reviews the current knowledge about mechanisms responsible for uraemic anorexia, the treatments and new drugs used to control the loss of a...

journal_title：Expert opinion on pharmacotherapy

authors： Aguilera A,Selgas R,Diéz JJ,Bajo MA,Codoceo R,Alvarez V

更新日期：2001-11-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension may occur in the context of incomplete lysis of acute pulmonary emboli, resulting in the obstruction of pulmonary blood flow, as well as progressive right ventricular dysfunction and failure. The treatment of choice for this condition is surgical removal of the obstructing...

journal_title：Expert opinion on pharmacotherapy

authors： Hughes R,Jais X,Suntharalingam J,Humbert M,Parent F,Simonneau G,Pepke-Zaba J

更新日期：2006-06-01 00:00:00

abstract：INTRODUCTION:Following more than 20 years of Interferon (IFN)-based treatment for hepatitis C virus (HCV), the understanding of viral life cycle led to the development of new antiviral drugs directly targeting HCV replication steps. Daclatasvir (DCV) is a potent inhibitor of non-structural NS5A HCV protein with pangeno...

journal_title：Expert opinion on pharmacotherapy

authors： Degasperi E,Aghemo A,Colombo M

更新日期：2015-01-01 00:00:00

abstract：:Amyotrophic [corrected] lateral sclerosis (ALS) is a progressive degenerative condition of motor neurons that is ultimately fatal. Even though scientific discovery over the past few decades has led to a greater understanding of the pathogenic mechanisms of ALS, effective pharmacotherapy intended to slow, arrest or rev...

journal_title：Expert opinion on pharmacotherapy

authors： Weiss MD,Weydt P,Carter GT

更新日期：2004-04-01 00:00:00

abstract：:Vascular injury is a ubiquitous phenomenon which can be both occult (such as with hyperlipidemia) and overt (such as with angioplasty). While the exact pathophysiology differs between acute and chronic atherosclerosis, both lesions can be mechanistically explained by the vasculature's exaggerated response to injury. P...

journal_title：Expert opinion on pharmacotherapy

authors： Selzman CH

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Lopinavir is a protease inhibitor with high specificity for HIV-1 protease formulated with ritonavir. Numerous clinical trials have shown that lopinavir/ritonavir (LPV/r) is highly effective as a component of highly active antiretroviral therapy (HAART) regimens for HIV-1 infection. OBJECTIVE:In this articl...

journal_title：Expert opinion on pharmacotherapy

authors： Barragan P,Podzamczer D

更新日期：2008-09-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a chronic, inflammatory disease afflicting 2% of the US population; it results in significant morbidity. The annual healthcare costs related to psoriasis are an estimated $11.3 billion and, with an expanding biologic market, an updated costs analysis is needed. AREAS COVERED:Current treatment...

journal_title：Expert opinion on pharmacotherapy

authors： Staidle JP,Dabade TS,Feldman SR

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Moderate-to-severe AD burdens a large proportion of AD patients and may represent an inadequacy of treatment options available for resistant disease. AREAS COVERED:This review provides an overview of the therapies for moderate-to-severe AD in late-stage development and in the clinic, and focuses on barici...

journal_title：Expert opinion on pharmacotherapy

authors： Mendes JT,Balogh EA,Strowd LC,Feldman SR

更新日期：2020-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Rhinosinusitis is a common illness that represents a substantial economic burden. The vast majority of cases resolve spontaneously but a small proportion develops a secondary bacterial infection. Accurate diagnosis of rhinosinusitis depends upon clinical assessment. Isolation of the causative ag...

journal_title：Expert opinion on pharmacotherapy

authors： Brook I

更新日期：2010-04-01 00:00:00

abstract：:Somatropin (rDNA origin) injection (Zorbtive) is a highly purified preparation of human growth hormone (GH) produced from a mammalian cell line by recombinant DNA technology. It is the only human GH approved for the treatment of short bowel syndrome in patients receiving specialised nutritional support. The process of...

journal_title：Expert opinion on pharmacotherapy

authors： Matarese LE,Abu-Elmagd K

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:The treatment of classical Hodgkin lymphoma (cHL) in children is a story of success. Nowadays, more than 90% of patients are cured and overall survival is nearly 100% at 5 years. Efforts have been made to avoid related effects of therapies; therefore, children are treated using different chemotherapy schem...

journal_title：Expert opinion on pharmacotherapy

authors： Gómez-Almaguer D,González-Llano O,Jiménez-Antolinez V,Gómez-De León A

更新日期：2019-07-01 00:00:00

abstract：INTRODUCTION:In non-exacerbation chronic obstructive pulmonary disease (COPD) with mild lung function impairment, single bronchodilator therapy might be as effective as combined inhaled corticosteroid/bronchodilator therapy, whereas the risk of pneumonia associated with the latter would be practically absent. AREAS CO...

journal_title：Expert opinion on pharmacotherapy

authors： Ruxandra U,Antoniu SA,Mihaltan F,Boisteanu D

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Tubulin inhibitors including taxanes and vinca alkaloids are important components of chemotherapy regimens used in advanced non-small cell lung cancer (NSCLC). Despite a treatment paradigm shift due to molecularly-targeted therapies and immunotherapy, a majority of patients will receive chemotherapy during...

journal_title：Expert opinion on pharmacotherapy

authors： Hardin C,Shum E,Singh AP,Perez-Soler R,Cheng H

更新日期：2017-05-01 00:00:00

abstract：:Negative symptoms are core features of schizophrenia that respond poorly to first-generation antipsychotics and present a major obstacle in rehabilitation. Patients may be somewhat more responsive to clozapine and second-generation antipsychotics but even then, considerable impairment remains. This paper reviews the u...

journal_title：Expert opinion on pharmacotherapy

authors： Silver H

更新日期：2004-10-01 00:00:00