Cilostazol and atherogenic dyslipidemia: a clinically relevant effect?

abstract：:Colesevelam HCl (WelChol, Sankyo Pharmaceuticals Inc.) is a bile acid sequestrant polymer, which has been shown to significantly lower low density lipoprotein cholesterol and favourably affect high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins (HMG-CoA reductase inhibitors...

journal_title：Expert opinion on pharmacotherapy

authors： Bays H,Dujovne C

更新日期：2003-05-01 00:00:00

abstract：INTRODUCTION:Much research has gone into developing medications that can be used to alleviate endometriosis-associated symptoms. In addition to already established medications, a new GnRH antagonist, elagolix, is in development. The novelty of this drug compared to other GnRH antagonists, is its nonpeptide structure, a...

journal_title：Expert opinion on pharmacotherapy

authors： Perricos A,Wenzl R

更新日期：2017-09-01 00:00:00

abstract：INTRODUCTION:Hyperphosphatemia in chronic kidney disease (CKD) is considered as an independent risk factor for surrogate clinical end points like vascular calcification (VC) and bone disease, or hard clinical outcomes like cardiovascular events. Various treatment options are available for phosphate removal or reduction...

journal_title：Expert opinion on pharmacotherapy

authors： Spasovski G

更新日期：2015-01-01 00:00:00

abstract：:Urinary tract infections (UTIs) are among the most commonly encountered bacterial infections. Acute uncomplicated UTIs in adults include episodes of cystitis and pyelonephritis. The main uropathogens causing uncomplicated UTIs have, in the past, been fairly predictable and they have generally been susceptible to sever...

journal_title：Expert opinion on pharmacotherapy

authors： Garrison J,Hooton TM

更新日期：2001-08-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACE-Is) are an evidence-based treatment for patients who after myocardial infarction (MI) present with either heart failure (HF) or left ventricular systolic dysfunction, or both. An alternative could be a more complete inhibition of the renin-angiotensin system through the bl...

journal_title：Expert opinion on pharmacotherapy

authors： Maggioni AP,Fabbri G

更新日期：2005-03-01 00:00:00

abstract：:Ankylosing spondylitis (AS) is a frequent disease leading to functional impairment and socioeconomic burden. Anti-TNF-alpha therapy has brought new perspectives in this condition. Two agents are currently used in the treatment of AS and spondyloarthropathies - infliximab (a chimeric monoclonal antibody) and etanercept...

journal_title：Expert opinion on pharmacotherapy

authors： Wendling D,Toussirot E

更新日期：2004-07-01 00:00:00

abstract：:Vascular injury is a ubiquitous phenomenon which can be both occult (such as with hyperlipidemia) and overt (such as with angioplasty). While the exact pathophysiology differs between acute and chronic atherosclerosis, both lesions can be mechanistically explained by the vasculature's exaggerated response to injury. P...

journal_title：Expert opinion on pharmacotherapy

authors： Selzman CH

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:Immune-checkpoint inhibitor (ICPI) drugs, which include antibodies against CTLA-4, PD-1 and PD-L1, have been shown to induce durable complete responses in a proportion of patients with particular efficacy demonstrated in both the first line and refractory setting in advanced NSCLC and melanoma. However, th...

journal_title：Expert opinion on pharmacotherapy

authors： Flynn MJ,Larkin JMG

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Our knowledge about lower respiratory tract infections (LRTIs) has improved substantially in the last years, but the management of respiratory infections is still a challenge and we are still far from using precision medicine in their treatment. Areas covered: The approaches developed in recent years to im...

journal_title：Expert opinion on pharmacotherapy

authors： Cazzola M,Rogliani P,Aliberti S,Blasi F,Matera MG

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Skin and skin structure infections are frequently encountered in clinical practice. Fortunately, these infections usually produce only mild to moderate symptoms and signs. Some, however, are severe and may even be life-threatening. OBJECTIVE:To review the approach to the evaluation and treatment of patients...

journal_title：Expert opinion on pharmacotherapy

authors： Cornia PB,Davidson HL,Lipsky BA

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Benign prostate hyperplasia (BPH) is one of the most prevalent diseases in aging men. It may adversely affect quality-of-life due to the presence of low urinary tract symptoms (LUTS) and its effects on sexuality. AREAS COVERED:The impact of α1-blockers, 5α-reductase inhibitors (5-ARI), and phosphodiestera...

journal_title：Expert opinion on pharmacotherapy

authors： La Vignera S,Aversa A,Cannarella R,Condorelli RA,Duca Y,Russo GI,Calogero AE

更新日期：2020-09-09 00:00:00

abstract：INTRODUCTION:Insomnia in Major Depressive Disorder (MDD) is highly prevalent and associated with increased suffering and functional impairment. Effective, evidence-based treatments for insomnia in MDD are an unmet need in clinical practice. AREAS COVERED:Herein, the authors provide a review of the clinical correlates,...

journal_title：Expert opinion on pharmacotherapy

authors： Brietzke E,Vazquez GH,Kang MJY,Soares CN

更新日期：2019-08-01 00:00:00

abstract：:Seborrhoeic dermatitis (SD) is a chronic, inflammatory skin disorder, affecting areas of the head and body where sebaceous glands are most prominent and active. The disorder commonly affects hair-bearing areas of the head, including the scalp. Involvement on the face is usually limited to the hairline, eyebrows, nasol...

journal_title：Expert opinion on pharmacotherapy

authors： Faergemann J,Borgers M,Degreef H

更新日期：2007-06-01 00:00:00

abstract：:Elevated blood pressure levels are highly prevalent and are a major reason for cardiovascular events and thus place a significant financial burden on healthcare systems worldwide. Guidelines recommend five first-line anti-hypertensive drug classes, but compelling indications may indicate favoring one drug class over a...

journal_title：Expert opinion on pharmacotherapy

authors： Bramlage P,Durand-Zaleski I,Desai N,Pirk O,Hacker C

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Pegaptanib sodium, the first aptamer therapeutic approved for use and the first antiangiogenic agent used to treat ocular neovascular disease, acts by inhibiting the 165 isoform of vascular endothelial growth factor believed primarily responsible for pathologic ocular neovascularization and vascular permeabi...

journal_title：Expert opinion on pharmacotherapy

authors： Apte RS

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Multiple sclerosis (MS) is an autoimmune neurodegenerative disease of the central nervous system involving inflammation, chronic demyelination and axonal loss. MS affects more than 2 million people worldwide. AREAS COVERED:This article aims to summarize the findings from two pivotal 2-year, randomized, do...

journal_title：Expert opinion on pharmacotherapy

authors： Havrdova E,Hutchinson M,Kurukulasuriya NC,Raghupathi K,Sweetser MT,Dawson KT,Gold R

更新日期：2013-10-01 00:00:00

abstract：:Memantine is the first and only medication that has been approved by European, US and Canadian regulatory agencies for the treatment of moderate-to-severe Alzheimer's disease (AD). It is an NMDA receptor antagonist that works to prevent excitotoxicity and cell death, which are mediated by the excessive influx of calci...

journal_title：Expert opinion on pharmacotherapy

authors： Cosman KM,Boyle LL,Porsteinsson AP

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:The skin and the brain interact through psychoneuroimmunoendocrine mechanisms and through behaviors that can strongly influence the initiation or flaring of skin disorders. OBJECTIVE:To obtain knowledge of these factors to assist in designing treatment plans for specific skin disorders. METHODS:Psychocutan...

journal_title：Expert opinion on pharmacotherapy

authors： Shenefelt PD

更新日期：2008-04-01 00:00:00

abstract：:Recognising the value added by economic evaluations of clinical trials and the interaction of clinical, humanistic and economic end points, the Radiation Therapy Oncology Group (RTOG) has developed an Outcomes Model that guides the comprehensive assessment of this triad of end points. This paper will focus on the econ...

journal_title：Expert opinion on pharmacotherapy

authors： Konski A,Watkins-Bruner D,RTOG (Radiation Therapy Oncology Group) Outcomes Model.

更新日期：2004-03-01 00:00:00

abstract：INTRODUCTION:Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carb...

journal_title：Expert opinion on pharmacotherapy

authors： Wu G,Cheon E

更新日期：2018-09-01 00:00:00

abstract：INTRODUCTION:Aripiprazole long acting once-monthly (AOM) is approved for the treatment of schizophrenia in adults. Despite recent evidence of AOM efficacy in the acute treatment of schizophrenia, it is recommended that AOM should be started once the acute symptoms are controlled and patients are stabilized. However, th...

journal_title：Expert opinion on pharmacotherapy

authors： Amodeo G,Candiracci C,Capecci I,De Filippis S,Giuliani S,Guerani G,Tomasetti C,Villari V,Fagiolini A

更新日期：2016-11-01 00:00:00

abstract：INTRODUCTION:Adjunctive pharmacotherapy is of key importance in determining the outcomes of percutaneous coronary intervention (PCI). In parallel, there has been an increasing body of evidence indicating that the aggressive management of coronary risk factors and changes in lifestyle behavior yield additional positive ...

journal_title：Expert opinion on pharmacotherapy

authors： Capodanno D,Tamburino C,Dangas G

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:Glioblastoma multiforme (GBM) is the most common high grade primary brain tumor in adults. Despite significant advances in treatment, the prognosis remains poor. Bevacizumab (BVZ) and irinotecan (CPT-11) are currently being investigated in the treatment of GBM patients. Although treatment with BVZ and irin...

journal_title：Expert opinion on pharmacotherapy

authors： Jakobsen JN,Hasselbalch B,Stockhausen MT,Lassen U,Poulsen HS

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worldwide and has contributed to over 650,000 deaths. This review synthesizes the literature on COVID-19 pharmacotherapy to inform practice and policymaking. A...

journal_title：Expert opinion on pharmacotherapy

authors： Khan S,Gionfriddo MR,Cortes-Penfield N,Thunga G,Rashid M

更新日期：2020-10-01 00:00:00

abstract：INTRODUCTION:Short bowel syndrome (SBS) has traditionally been regarded as a rapidly fatal medical catastrophe. The advent of pharmacological options directly targeting disease pathophysiology justified this review. AREAS COVERED:Since the 1970s, home parenteral nutrition has reduced mortality, converting SBS into a c...

journal_title：Expert opinion on pharmacotherapy

authors： Hollanda Martins Da Rocha M,Lee ADW,Marin MLM,Faintuch S,Mishaly A,Faintuch J

更新日期：2020-04-01 00:00:00

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：INTRODUCTION:Chronic lymphocytic leukemia (CLL) is a common hematologic malignancy with a highly variable clinical course. Frontline treatments include cytotoxic chemotherapies, immunotherapies, and small molecule inhibitors. Clinical and molecular factors guide treatment initiation and selection. Over the last decade,...

journal_title：Expert opinion on pharmacotherapy

authors： Samples LS,Graf SA

更新日期：2018-10-01 00:00:00

abstract：:Involvement of viruses in the pathogenesis of multiple sclerosis (MS) is a long-lived hypothesis, which is has not yet been proven nor refuted. This is partly due to difficulties in the evaluation of diagnostic findings on persistent infections by common viruses such as herpesviruses and endogenous retroviruses. Progr...

journal_title：Expert opinion on pharmacotherapy

authors： Bergström T

更新日期：2000-09-01 00:00:00

abstract：INTRODUCTION:Loss of bone mineral density is an emerging problem in persons living with HIV infection. Earlier and more rapid bone demineralization has been attributed not only to the high prevalence of traditional risk factors, but also to specific HIV-related factors. The aim of this guidance is to stimulate an appro...

journal_title：Expert opinion on pharmacotherapy

authors： Negredo E,Bonjoch A,Clotet B

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00