Pharmacological management of renal fibrotic disease.

abstract：INTRODUCTION:Acute decompensated heart failure (ADHF) contributes largely to the burden of heart failure and is associated with a poorer prognosis. Although numerous clinical trials evaluated the benefit of newer medications for ADHF, most of them were not successful. Areas covered: This review focusses on the updates ...

journal_title：Expert opinion on pharmacotherapy

authors： Yandrapalli S,Tariq S,Aronow WS

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To investigate the impact of daily sildenafil on levels of soluble molecular markers of endothelial function in men with erectile dysfunction. METHODS:Patients aged >18 years with erectile dysfunction of vascular etiology for >6 months, either alone or in combination with disease states strongly associated w...

journal_title：Expert opinion on pharmacotherapy

authors： Konstantinopoulos A,Giannitsas K,Athanasopoulos A,Spathas D,Perimenis P

更新日期：2009-02-01 00:00:00

abstract：INTRODUCTION:Hairy cell leukemia (HCL) is a B-cell lymphoid malignancy that accounts for approximately 2% of all leukemias. Treatment with purine nucleoside analogs (PNA) results in a high response rate and remains the standard of care. Long term follow-up shows that most patients relapse and require retreatment. Newer...

journal_title：Expert opinion on pharmacotherapy

authors： Ramos Perez J,Ravandi-Kashani F

更新日期：2020-08-01 00:00:00

abstract：INTRODUCTION:In the 40-50% of advanced melanoma patients with tumors harboring BRAF V600E and V600 K mutations, BRAF inhibitors such as dabrafenib are a highly effective treatment. However, most patients develop resistance after several months on treatment. The addition of a MEK inhibitor, such as trametinib, to BRAF i...

journal_title：Expert opinion on pharmacotherapy

authors： Spain L,Julve M,Larkin J

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:The late effects of cancer treatment have recently gained a worldwide ubiquitous interest among reproductive endocrinologists, oncologists, and all health care providers. Despite many publications on this subject, there are many equivocal issues necessitating summary. The case for and against using GnRH-ag...

journal_title：Expert opinion on pharmacotherapy

authors： Blumenfeld Z,Evron A

更新日期：2015-05-01 00:00:00

abstract：:Ramipril is an angiotensin-converting enzyme inhibitor that has been extensively studied in randomised, controlled clinical trials in patients with cardiovascular diseases. Therapy with ramipril in patients with various cardiovascular disorders has demonstrated significant and clinically important reductions in cardio...

journal_title：Expert opinion on pharmacotherapy

authors： Rokoss MJ,Teo KK

更新日期：2005-09-01 00:00:00

abstract：:Initially it was considered that moxonidine, like clonidine, acted at central (2)-adrenoceptors to reduce blood pressure. With the characterisation of imidazoline binding sites distinct from (2)-adrenoceptors, the consensus became that moxonidine was acting predominantly at imidazoline I(1) receptors in the rostral ve...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2001-02-01 00:00:00

abstract：INTRODUCTION:Ceftazidime is a third-generation cephalosporin that has activity against Gram-negative bacilli, including Pseudomonas aeruginosa. The increasing prevalence of antimicrobial resistance and the limited number of antimicrobial agents in development have necessitated a review of the current status of treatmen...

journal_title：Expert opinion on pharmacotherapy

authors： Choi SH,Koh Y

更新日期：2012-10-01 00:00:00

abstract：:Developments in the role of adjuvant and neoadjuvant chemotherapy for the treatment of patients with breast cancer have focused on the taxes, in particular, docetaxel. This paper discusses the rationale for the introduction of docetaxel into the management of patients following surgery and also its role in those patie...

journal_title：Expert opinion on pharmacotherapy

authors： Heys SD,Sarkar T,Hutcheon AW

更新日期：2004-10-01 00:00:00

abstract：:Hydrocephalus is an excess accumulation of cerebrospinal fluid in or around the brain that can be produced by a broad spectrum of disorders. It can develop at any age and its incidence is increasing, both in infants and adults. Although the standard treatment of hydrocephalus is cerebrospinal fluid shunting, there are...

journal_title：Expert opinion on pharmacotherapy

authors： Poca MA,Sahuquillo J

更新日期：2005-08-01 00:00:00

abstract：INTRODUCTION:Hyperphosphatemia in chronic kidney disease (CKD) is considered as an independent risk factor for surrogate clinical end points like vascular calcification (VC) and bone disease, or hard clinical outcomes like cardiovascular events. Various treatment options are available for phosphate removal or reduction...

journal_title：Expert opinion on pharmacotherapy

authors： Spasovski G

更新日期：2015-01-01 00:00:00

abstract：:Dermatomyositis is traditionally classified as one of the idiopathic inflammatory myopathies. The traditional approach to the management of patients with dermatomyositis focuses predominantly on end points related to the systemic manifestations of this disorder, especially proximal muscle weakness resulting from myosi...

journal_title：Expert opinion on pharmacotherapy

authors： Sontheimer RD

更新日期：2004-05-01 00:00:00

abstract：INTRODUCTION:Hodgkin lymphoma (HL) is a lymphoid malignancy with an incidence of 2 - 3/100,000/year. Young adults are most often affected. Due to the development of highly active multi-agent chemotherapy protocols and the optimization of radiotherapy (RT) fields and doses, HL has become one of the malignancies with the...

journal_title：Expert opinion on pharmacotherapy

authors： Eichenauer DA,Böll B,Diehl V

更新日期：2014-06-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：:Introduction: This clinical guidance looks at the specific concerns of delivery of medical treatment for people with epilepsy and intellectual disability (ID). People with ID have not been included in licensing drug trials of AEDs. However, this population has an over-representation of seizure comorbidity, treatment r...

journal_title：Expert opinion on pharmacotherapy

authors： Watkins L,O'Dwyer M,Kerr M,Scheepers M,Courtenay K,Shankar R

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common skin disorder characterized by chronic inflammatory lesions that are frequently vexing for patients and difficult for physicians to treat. Although multiple therapeutic options are available, all have limitations. Topical preparations have issues with patient adherence, as compared to...

journal_title：Expert opinion on pharmacotherapy

authors： Shutty B,West C,Pellerin M,Feldman S

更新日期：2012-08-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Most guidelines suggest that failure of oral antidiabetic drugs should be followed by the addition of a basal insulin with aggressive titration of the dose. In most countries, neutral protamine Hagedorn (NPH)-insulin, glargine and detemir are the only choices. Clinical trials show that the metab...

journal_title：Expert opinion on pharmacotherapy

authors： Jensen MG,Hansen M,Brock B,Rungby J

更新日期：2010-08-01 00:00:00

abstract：:Chronic thromboembolic pulmonary hypertension may occur in the context of incomplete lysis of acute pulmonary emboli, resulting in the obstruction of pulmonary blood flow, as well as progressive right ventricular dysfunction and failure. The treatment of choice for this condition is surgical removal of the obstructing...

journal_title：Expert opinion on pharmacotherapy

authors： Hughes R,Jais X,Suntharalingam J,Humbert M,Parent F,Simonneau G,Pepke-Zaba J

更新日期：2006-06-01 00:00:00

abstract：INTRODUCTION:Transurethral resection of bladder tumor (TURBT) is the gold standard initial diagnostic intervention for bladder cancer and provides diagnostic, therapeutic and prognostic benefit in non-muscle-invasive bladder cancer (NMIBC). However, TURBT alone is inadequate for optimal management of NMIBC, as patients...

journal_title：Expert opinion on pharmacotherapy

authors： Patel SG,Cohen A,Weiner AB,Steinberg GD

更新日期：2015-04-01 00:00:00

abstract：INTRODUCTION:Despite its frequency, recognition and therapy of vulvovaginal atrophy (VVA) remain suboptimal. Wet mount microscopy, or vaginal pH as a proxy, allows VVA diagnosis in menopause, but also in young contraception users, after breast cancer, or postpartum. Intravaginal low dose estrogen product is the main th...

journal_title：Expert opinion on pharmacotherapy

authors： Donders GGG,Ruban K,Bellen G,Grinceviciene S

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Gout is a common disease responsible for recurrent flares triggered by the deposition of monosodium urate crystals secondary to longstanding hyperuricaemia. The management of gout implies both the treatment of flares and the treatment of hyperuricaemia itself. Recent improvement in the understanding of the...

journal_title：Expert opinion on pharmacotherapy

authors： Pascart T,Richette P

更新日期：2017-08-01 00:00:00

abstract：:Alpha-1 antitrypsin (AAT) deficiency is an under-recognized genetic condition that predisposes to liver disease and early-onset emphysema. Although AAT is mainly produced in the liver, its main function is to protect the lung against proteolytic damage from neutrophil elastase. The most common mutation responsible for...

journal_title：Expert opinion on pharmacotherapy

authors： Modrykamien A,Stoller JK

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Dexmethylphenidate is a single-isomer stimulant medication approved for the treatment of attention deficit hyperactivity disorder (ADHD). Single-isomer drugs have the potential for decreased undesired effects and improved therapeutic efficacy. Stimulant medications have been the mainstay treatments for ADHD ...

journal_title：Expert opinion on pharmacotherapy

authors： Coury D

更新日期：2009-11-01 00:00:00

abstract：BACKGROUND:Moderate hypertriglyceridemia is fairly common, and elevated triglycerides are a risk factor for coronary heart disease. The omega-3 fatty acids EPA and DHA have been shown to lower triglycerides in many clinical studies. Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people wi...

journal_title：Expert opinion on pharmacotherapy

authors： Skulas-Ray AC,West SG,Davidson MH,Kris-Etherton PM

更新日期：2008-05-01 00:00:00

abstract：:Paracetamol (acetaminophen) is one of the over-the-counter analgesics that is used frequently for the self-management of some of the common disorders. There seems to be two types of relations between paracetamol and asthma - paracetamol intolerance leading to bronchospasm in analgesic-induced asthmatics; and the relat...

journal_title：Expert opinion on pharmacotherapy

authors： Karakaya G,Kalyoncu AF

更新日期：2003-01-01 00:00:00

abstract：:Screening for sexually transmitted diseases is included in routine health care for several infectious agents in many western European countries. Current considerations on extensions of these programs include widespread screening strategies for Chlamydia trachomatis. In women, C. trachomatis infection may lead to seque...

journal_title：Expert opinion on pharmacotherapy

authors： Postma MJ,Welte R,Morré SA

更新日期：2002-10-01 00:00:00

abstract：INTRODUCTION:Loss of bone mineral density is an emerging problem in persons living with HIV infection. Earlier and more rapid bone demineralization has been attributed not only to the high prevalence of traditional risk factors, but also to specific HIV-related factors. The aim of this guidance is to stimulate an appro...

journal_title：Expert opinion on pharmacotherapy

authors： Negredo E,Bonjoch A,Clotet B

更新日期：2016-01-01 00:00:00

abstract：:The burden of insomnia has had a significant effect not only on the socioeconomic matrix, but also the medical terrain, as signified by the increased morbidity and mortality of its associated psychiatric and organic sequelae. To this end, a plethora of pharmacotherapeutic agents have been recently introduced that addr...

journal_title：Expert opinion on pharmacotherapy

authors： Navab P,Guilleminault C

更新日期：2006-09-01 00:00:00

abstract：INTRODUCTION:Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic met...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Hermanns-Lê T,Delvenne P,Piérard-Franchimont C

更新日期：2012-06-01 00:00:00

abstract：:Introduction: The current recommendations of chronic obstructive pulmonary disease (COPD) suggest to escalate from inhaled corticosteroid/long-acting β2-adrenoceptor agonist (ICS/LABA) treatment to triple therapy in patients experiencing persistent breathlessness, exercise limitation, or exacerbation. The addition of ...

journal_title：Expert opinion on pharmacotherapy

authors： Ritondo BL,Puxeddu E,Calzetta L,Cazzola M,Rogliani P

更新日期：2020-11-11 00:00:00