The pharmacological management of cardiovascular disease in people living with HIV (PLWH).

abstract：:Introduction: Hypertrophic cardiomyopathy (HCM) is one of the most common genetic heart diseases and represents a leading cause of sudden cardiac death as well as a prevalent cause of heart failure and stroke. HCM is characterized by a very complex pathophysiology, consisting of heterogeneous clinical manifestations a...

journal_title：Expert opinion on pharmacotherapy

authors： Spoladore R,Fragasso G,Pannone L,Slavich M,Margonato A

更新日期：2020-02-01 00:00:00

abstract：INTRODUCTION:Pharmacological treatment plays a major role in the management of advanced, persistent or recurrent uterine leiomyosarcoma (LMS), whereas its usefulness in the adjuvant setting is still debated. A thorough literature search was undertaken using the Pubmed databases. Systematic reviews and controlled trials...

journal_title：Expert opinion on pharmacotherapy

authors： Gadducci A,Guerrieri ME

更新日期：2015-02-01 00:00:00

abstract：INTRODUCTION:Glioblastoma multiforme (GBM) is the most common high grade primary brain tumor in adults. Despite significant advances in treatment, the prognosis remains poor. Bevacizumab (BVZ) and irinotecan (CPT-11) are currently being investigated in the treatment of GBM patients. Although treatment with BVZ and irin...

journal_title：Expert opinion on pharmacotherapy

authors： Jakobsen JN,Hasselbalch B,Stockhausen MT,Lassen U,Poulsen HS

更新日期：2011-04-01 00:00:00

abstract：INTRODUCTION:Irritability (including tantrums, aggression and moodiness) is often associated with autistic disorder. Children with autism are frequently prescribed atypical antipsychotic medications for these behaviors. Although multiple agents have been found to be effective, the safety and tolerability of each antips...

journal_title：Expert opinion on pharmacotherapy

authors： Farmer CA,Aman MG

更新日期：2011-03-01 00:00:00

abstract：:Despite recent evidence suggesting that Bell's palsy is associated with reactivation of alfa-herpes viruses, the disease has been treated empirically, and the use of valacyclovir has not been definitively established. In 2007, two prospective, randomised, placebo-controlled trials evaluating valacyclovir were reported...

journal_title：Expert opinion on pharmacotherapy

authors： Hato N,Sawai N,Teraoka M,Wakisaka H,Takahashi H,Hinohira Y,Gyo K

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:actinic keratosis is a premalignant disease with a high incidence and is a strong predictor for the development of squamous cell carcinoma. Various treatment options have been established over recent years, including topical treatment with imiquimod, 5-fluorouracil, diclofenac or photodynamic therapy, cryo...

journal_title：Expert opinion on pharmacotherapy

authors： Quist SR,Gollnick HP

更新日期：2011-02-01 00:00:00

abstract：INTRODUCTION:In this review, the authors describe medications in phase III of clinical development for schizophrenia and schizoaffective disorder, and provide an opinion on how current treatment can be improved in the near future. AREAS COVERED:Recent (post 2013) phase III clinical trials of schizophrenia-targeted the...

journal_title：Expert opinion on pharmacotherapy

authors： Garay RP,Citrome L,Samalin L,Liu CC,Thomsen MS,Correll CU,Hameg A,Llorca PM

更新日期：2016-01-01 00:00:00

abstract：:The development of effective treatments for opioid dependence is of great importance given the devastating consequences of the disease. Pharmacotherapies for opioid addiction include opioid agonists, partial agonists, opioid antagonists, and alpha-2-adrenergic agonists, which are targeted toward either detoxification ...

journal_title：Expert opinion on pharmacotherapy

authors： Stotts AL,Dodrill CL,Kosten TR

更新日期：2009-08-01 00:00:00

abstract：INTRODUCTION:Despite its frequency, recognition and therapy of vulvovaginal atrophy (VVA) remain suboptimal. Wet mount microscopy, or vaginal pH as a proxy, allows VVA diagnosis in menopause, but also in young contraception users, after breast cancer, or postpartum. Intravaginal low dose estrogen product is the main th...

journal_title：Expert opinion on pharmacotherapy

authors： Donders GGG,Ruban K,Bellen G,Grinceviciene S

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:Breast cancer is the most frequently diagnosed cancer and the highest cause of cancer mortality in females worldwide. The development of drugs improving overall survival in late-stage metastatic breast cancer remains a challenge. Vinflunine is the most recently developed drug in the vinca alkaloid class. I...

journal_title：Expert opinion on pharmacotherapy

authors： Gourmelon C,Bourien H,Augereau P,Patsouris A,Frenel JS,Campone M

更新日期：2016-09-01 00:00:00

abstract：:Diabetes mellitus is now occurring in epidemic proportions in many countries. Owing to the limited effectiveness of drug prophylaxis of diabetic complications after diabetes has developed, it may be more appropriate to investigate ways to prevent the onset of diabetes. A recent trial published by the Diabetes Preventi...

journal_title：Expert opinion on pharmacotherapy

authors： Doggrell SA

更新日期：2002-07-01 00:00:00

abstract：INTRODUCTION:As type 2 diabetes mellitus (T2DM) advances, patients receiving basal insulin will eventually require another agent on top of their current regimen in order to achieve glycemic control. One such agent that can be administered in combination with basal insulin is the glucagon-like peptide-1 receptor agonist...

journal_title：Expert opinion on pharmacotherapy

authors： Forst T

更新日期：2016-08-01 00:00:00

abstract：INTRODUCTION:Malaria in pregnancy continues to be a significant public health burden globally, with over 100 million women at risk each year. Sulfadoxine-pyrimethamine (SP) is the only antimalarial recommended for intermittent preventive therapy in pregnancy (IPTp) but increasing parasite resistance threatens its viabi...

journal_title：Expert opinion on pharmacotherapy

authors： Moore BR,Davis TME

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Patients with rheumatoid arthritis (RA) have an increased risk of atherosclerotic cardiovascular disease which cannot be explained by traditional cardiovascular risk factors alone. Atherosclerosis is considered an inflammatory condition and inflammation experienced in RA may contribute to accelerated atheros...

journal_title：Expert opinion on pharmacotherapy

authors： Avouac J,Allanore Y

更新日期：2008-05-01 00:00:00

abstract：INTRODUCTION:Graves' hyperthyroidism is associated with significant morbidity and mortality risk. The thionamides, methimazole, its pro-drug derivative carbimazole, and propylthiouracil, remain a cornerstone of management. Yet despite decades of use, optimal strategies for maximising treatment response and curtailing a...

journal_title：Expert opinion on pharmacotherapy

authors： Okosieme OE,Lazarus JH

更新日期：2016-10-01 00:00:00

abstract：INTRODUCTION:Anaerobes are the most predominant components of normal human skin and mucous membrane bacterial flora and are, therefore, a common cause of endogenous bacterial infections. Because of their fastidious nature, they are difficult to isolate from infectious sites and are often overlooked. Anaerobic infection...

journal_title：Expert opinion on pharmacotherapy

authors： Brook I

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carb...

journal_title：Expert opinion on pharmacotherapy

authors： Wu G,Cheon E

更新日期：2018-09-01 00:00:00

abstract：:Pharmacological relapse prevention in alcoholism is a rather new clinical field with few drugs being available. Acamprosate, acting predominantly via glutamatergic pathways, and the opioid receptor antagonist naltrexone, were both shown to be efficient in improving rates for continuous abstinence, and not relapsing to...

journal_title：Expert opinion on pharmacotherapy

authors： Soyka M,Roesner S

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Moderate hypertriglyceridemia is fairly common, and elevated triglycerides are a risk factor for coronary heart disease. The omega-3 fatty acids EPA and DHA have been shown to lower triglycerides in many clinical studies. Prescription omega-3 fatty acid concentrates (P-OM3) are indicated for use in people wi...

journal_title：Expert opinion on pharmacotherapy

authors： Skulas-Ray AC,West SG,Davidson MH,Kris-Etherton PM

更新日期：2008-05-01 00:00:00

abstract：:Thymomas and thymic carcinoma are rare neoplasms. Surgical resection is the cornerstone of effective therapy. Stage I disease is effectively treated by complete surgical resection. The role of radiation therapy in completely resected stage II disease remains controversial. Adjuvant radiation therapy is useful for loca...

journal_title：Expert opinion on pharmacotherapy

authors： Papadopoulos KP,Thomas CR Jr

更新日期：2005-06-01 00:00:00

abstract：:Interstitial cystitis is a clinical condition occurring predominantly in women characterised by irritative voiding symptoms in the form of urinary frequency, urgency and pain. Patient symptoms have the potential to significantly affect quality of life, posing a challenge to some to perform activities of daily living. ...

journal_title：Expert opinion on pharmacotherapy

authors： Lukban JC

更新日期：2003-11-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy of mitiglinide and sitagliptin, alone or in combination, on postprandial excursion and glycemic variability assessed by continuous glucose monitoring (CGM) in a single-day treatment setting. METHODS:This was a post hoc analysis of a randomized crossover study comparing the efficacy of...

journal_title：Expert opinion on pharmacotherapy

authors： Baek JH,Jin SM,Kaku K,Jung JA,Kim JR,Ko JW,Kim MJ,Lee SY,Huh WS,Kim JH

更新日期：2015-06-01 00:00:00

abstract：:The introduction of anti-TNFalpha therapy into the field of rheumatology has led to dramatic improvements in patient care, perhaps the most remarkable being in the management of ankylosing spondylitis. As experience with these compounds grows, their place in therapeutic strategy is becoming clearer, and it has been po...

journal_title：Expert opinion on pharmacotherapy

authors： Zochling J,Braun J

更新日期：2006-05-01 00:00:00

abstract：INTRODUCTION:Hodgkin lymphoma (HL) is a lymphoid malignancy with an incidence of 2 - 3/100,000/year. Young adults are most often affected. Due to the development of highly active multi-agent chemotherapy protocols and the optimization of radiotherapy (RT) fields and doses, HL has become one of the malignancies with the...

journal_title：Expert opinion on pharmacotherapy

authors： Eichenauer DA,Böll B,Diehl V

更新日期：2014-06-01 00:00:00

abstract：:There has been an increase in the incidence and prevalence of gout in the past several decades. A distinction needs to be made between the treatment of gout as an acute inflammatory disease and the lowering of the serum urate (SU) levels into a normal range. Treating acute gout attacks alone is not sufficient to preve...

journal_title：Expert opinion on pharmacotherapy

authors： Schlesinger N,Dalbeth N,Perez-Ruiz F

更新日期：2009-06-01 00:00:00

abstract：INTRODUCTION:The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions of people worldwide and has contributed to over 650,000 deaths. This review synthesizes the literature on COVID-19 pharmacotherapy to inform practice and policymaking. A...

journal_title：Expert opinion on pharmacotherapy

authors： Khan S,Gionfriddo MR,Cortes-Penfield N,Thunga G,Rashid M

更新日期：2020-10-01 00:00:00

abstract：:Actinic keratosis (AK) and basal cell carcinoma (BCC) are precancerous and cancerous skin lesions that should be treated especially when multiple or in cosmetically important areas. Apart from 5% 5-fluorouracil topical cream, which some feel is the gold standard topical treatment for AK, several invasive treatment mod...

journal_title：Expert opinion on pharmacotherapy

authors： Papadavid E,Stratigos AJ,Falagas ME

更新日期：2007-08-01 00:00:00

abstract：:With emphasis on the pulmonary circulation, three general types of vascular disease are discussed: fibroproliferative (atherosclerosis), cellular proliferative (endothelial neoplasms) and inflammatory (granulomatous vasculitis). The causes of these phenotypic responses are invariably multifactorial, but infectious age...

journal_title：Expert opinion on pharmacotherapy

authors： Egermayer P

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:This meta-analysis was conducted to analyze and compare the efficacy outcomes associated with the fentanyl iontophoretic transdermal system (ITS) and morphine intravenous (IV) patient-controlled analgesia (PCA) in the management of postoperative pain. RESEARCH DESIGN AND METHODS:This meta-analysis assessed t...

journal_title：Expert opinion on pharmacotherapy

authors： Sinatra RS,Viscusi ER,Ding L,Danesi H,Jones JB,Grond S

更新日期：2015-01-01 00:00:00

abstract：:Male breast cancer is an uncommon condition. It often occurs in settings in which there is an imbalance between androgens and oestrogens. Genetics plays an important role, as many cases are associated with mutations in BRCA2 or other genes. Male breast cancer occurs at an older age than female breast cancer and is fre...

journal_title：Expert opinion on pharmacotherapy

authors： Hayes TG

更新日期：2009-10-01 00:00:00