In diabetic foot infections antibiotics are to treat infection, not to heal wounds.

abstract：INTRODUCTION:Epilepsy is a serious and common chronic neurological disease with an urgent need for novel treatment options, because 30% of all epilepsy patients do not respond to currently available drugs. Retigabine/Ezogabine (RTG) is a third-generation antiepileptic drug (AED) with a novel mechanism of action. It enh...

journal_title：Expert opinion on pharmacotherapy

authors： Orhan G,Wuttke TV,Nies AT,Schwab M,Lerche H

更新日期：2012-08-01 00:00:00

abstract：INTRODUCTION:For the past three decades, carbapenems played a central role in our antibiotic armamentarium, trusted to effectively treat infections caused by drug-resistant bacteria. The utility of this class of antibiotics has been compromised by the emergence of resistance especially among Enterobacteriaceae. AREAS ...

journal_title：Expert opinion on pharmacotherapy

authors： Perez F,El Chakhtoura NG,Papp-Wallace KM,Wilson BM,Bonomo RA

更新日期：2016-01-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Prostate cancer is a common cancer and the role of adjuvant medical therapy continues to be investigated. An understanding of the use of adjuvant medical therapy is essential for the appropriate care of prostate cancer patients, especially for those with locally advanced or high-risk disease. A...

journal_title：Expert opinion on pharmacotherapy

authors： Sumey C,Flaig TW

更新日期：2011-01-01 00:00:00

abstract：:A randomized Phase III trial tested the efficacy of pemetrexed as maintenance treatment in patients with advanced non-small-cell lung cancer (NSCLC) who were without progression after completing four cycles of first-line platinum-based chemotherapy. The primary endpoint of the trial was progression-free survival (PFS)...

journal_title：Expert opinion on pharmacotherapy

authors： Gridelli C,Di Maio M

更新日期：2010-02-01 00:00:00

abstract：INTRODUCTION:Etravirine (TMC125) is an orally administered second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI) that is approved in treatment-experienced patients as addition to an optimized background therapy (OBT). AREAS COVERED:A Medline search was conducted of Phase II - IV clinical trials, as ...

journal_title：Expert opinion on pharmacotherapy

authors： Schrijvers R

更新日期：2013-06-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune condition traditionally viewed as a severe destructive disease affecting physical health and global wellbeing. The treatment strategies for RA have changed in the last decades from mainly symptomatic towards a more vigorous and targeted approac...

journal_title：Expert opinion on pharmacotherapy

authors： De Cock D,Van der Elst K,Meyfroidt S,Verschueren P,Westhovens R

更新日期：2015-01-01 00:00:00

abstract：:alpha-adrenoceptor antagonists have traditionally been used in the treatment of hypertension but in recent years they have become increasingly common in the treatment of benign prostatic enlargement (BPE), where they reduce the 'dynamic' component of bladder outlet obstruction and appear to have additional actions to ...

journal_title：Expert opinion on pharmacotherapy

authors： Chess-Williams R

更新日期：2002-02-01 00:00:00

abstract：:Colesevelam HCl (WelChol, Sankyo Pharmaceuticals Inc.) is a bile acid sequestrant polymer, which has been shown to significantly lower low density lipoprotein cholesterol and favourably affect high-density lipoprotein cholesterol blood levels in monotherapy and in combination with statins (HMG-CoA reductase inhibitors...

journal_title：Expert opinion on pharmacotherapy

authors： Bays H,Dujovne C

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE:To revisit the various aspects of action of the drug in a dermatologic setting. METHOD:Review of the current peer-reviewed publications. RESULTS/CONCLUSION:Miconazole essentially inhibits 14alpha-demethylase, an enzyme requi...

journal_title：Expert opinion on pharmacotherapy

authors： Quatresooz P,Vroome V,Borgers M,Cauwenbergh G,Piérard GE

更新日期：2008-08-01 00:00:00

abstract：:Poor therapeutic adherence is a major issue faced by physicians today. This paper summarizes the adherence rates with oral bisphosphonate (OBP) treatment in clinical practice and their impact on clinical outcomes. Studies systematically demonstrated that overall compliance and persistence with OBPs among osteoporotic ...

journal_title：Expert opinion on pharmacotherapy

authors： Rabenda V,Hiligsmann M,Reginster JY

更新日期：2009-10-01 00:00:00

abstract：INTRODUCTION:Tubulin inhibitors including taxanes and vinca alkaloids are important components of chemotherapy regimens used in advanced non-small cell lung cancer (NSCLC). Despite a treatment paradigm shift due to molecularly-targeted therapies and immunotherapy, a majority of patients will receive chemotherapy during...

journal_title：Expert opinion on pharmacotherapy

authors： Hardin C,Shum E,Singh AP,Perez-Soler R,Cheng H

更新日期：2017-05-01 00:00:00

abstract：:Motor fluctuations are a common problem in the long-term management of Parkinson's disease (PD), resulting in disability and impaired quality of life. The relatively short serum half-life (approximately 90 min) of oral levodopa/carbidopa and its erratic absorption due to delayed and inconsistent gastric emptying (a no...

journal_title：Expert opinion on pharmacotherapy

authors： Samanta J,Hauser RA

更新日期：2007-04-01 00:00:00

abstract：:The recently published Abaloparatide Comparator Trial in Vertebral Endpoints (ACTIVE) assessed the efficacy and safety of abaloparatide (80 µg daily subcutaneous) (ABL) vs placebo during 18 months, in postmenopausal osteoporosis. Teriparatide (20 µg daily subcutaneous) (TPD) was used as an open label active comparator...

journal_title：Expert opinion on pharmacotherapy

authors： Reginster JY,Al Daghri NM,Bruyere O

更新日期：2017-12-01 00:00:00

abstract：:Chemoradiotherapy is a standard treatment for both unresectable locally advanced non-small cell lung cancer and limited-stage small cell lung cancer. Cisplatin-based chemotherapy with concurrent thoracic radiotherapy yields a 5-year survival rate of approximately 15% for patients with unresectable locally advanced non...

journal_title：Expert opinion on pharmacotherapy

authors： Ohe Y

更新日期：2005-12-01 00:00:00

abstract：INTRODUCTION:Obesity is a growing health problem that has numerous comorbidities, including cardiovascular disease (CVD). The multi-disciplinary treatment of obesity now includes the use of pharmacotherapy. When treating patients with obesity and CVD, certain medications may be more appropriate than others. AREAS COVE...

journal_title：Expert opinion on pharmacotherapy

authors： Andrew CA,Saunders KH,Shukla AP,Aronne LJ

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Seizures or chronic epilepsy are a relatively common occurrence in a neurosurgical setting. However, seizure treatment after neurosurgery has received less attention compared with other causes and only few data are availaible in the literature on management in neurosurgical patients. Areas covered: This pa...

journal_title：Expert opinion on pharmacotherapy

authors： Ambrosi M,Orsini A,Verrotti A,Striano P

更新日期：2017-10-01 00:00:00

abstract：:Chronic refractory angina is a term used to describe patients who, despite optimal medical therapy, have both angina and objective evidence of ischaemia. It is estimated that 5-15% of the 12 million patients with chronic angina in the US meet the criteria for having refractory angina. This review focuses on the follow...

journal_title：Expert opinion on pharmacotherapy

authors： Yang EH,Barsness GW

更新日期：2006-02-01 00:00:00

abstract：:Several studies have revealed the intimate associations between erectile dysfunction (ED), ischemic heart disease (IHD) and depression. Whether the physicians should also screen for the other two components when a patient presents with one component of this triad is still an important question to be answered. These th...

journal_title：Expert opinion on pharmacotherapy

authors： El-Sakka AI,Shamloul R,Yassin AA

更新日期：2009-09-01 00:00:00

abstract：INTRODUCTION:When estimating the cost-effectiveness or budget impact of chronic obstructive pulmonary disease (COPD) medication, it is common practice to use trial data for clinical inputs. However, such inputs do not always reflect the real-world situation. Previous reviews recognized the need for taking real-world da...

journal_title：Expert opinion on pharmacotherapy

authors： Fens T,Zhou G,Postma MJ,van Puijenbroek EP,van Boven JFM

更新日期：2021-01-13 00:00:00

abstract：:A number of medicine selection methods have been used worldwide for formulary purposes. In Northern Ireland, integrated medicines management is being developed, and related projects have been carried out. This paper deals with the description of the STEPS (Safe Therapeutic Economic Pharmaceutical Selection) programme....

journal_title：Expert opinion on pharmacotherapy

authors： Scott M,Timoney M,Mairs J,Crealey G,Al Abaddi I,Brenninkmeijer R,Janknegt R,McElnay J

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:Rheumatoid arthritis (RA) can spontaneously improve during pregnancy. However, a considerable proportion of patients can experience a flare and high disease activity has been associated with an increased risk of adverse pregnancy outcome. Thus, the treatment of RA in pregnant women should be selected takin...

journal_title：Expert opinion on pharmacotherapy

authors： Gerosa M,Schioppo T,Meroni PL

更新日期：2016-08-01 00:00:00

abstract：:Neonatal herpes is a potentially devastating consequence of perinatal transmission of the herpes simplex virus (HSV), with significant morbidity and mortality. Treatment options are available, but must begin early in disease with manifestations that are often protean. Thus, preventive measures need to be optimised. An...

journal_title：Expert opinion on pharmacotherapy

authors： Leung DT,Sacks SL

更新日期：2003-10-01 00:00:00

abstract：INTRODUCTION:Psoriasis is a common immune-mediated disorder that in 70% of cases appears in mild or mild-to-moderate form. Psoriasis is usually treated with topical medications and/or phototherapy with variable efficacy in controlling the disease. AREAS COVERED:For the past three decades, research has been focused on ...

journal_title：Expert opinion on pharmacotherapy

authors： Chiricozzi A,Pitocco R,Saraceno R,Nistico SP,Giunta A,Chimenti S

更新日期：2014-03-01 00:00:00

abstract：:Oseltamivir is the ethyl ester prodrug of the antiviral molecule, oseltamivir carboxylate, a potent and selective inhibitor of influenza A and B neuraminidase (NA) (sialidase). It is highly bioavailable in capsule and suspension formulations and, after conversion to the active metabolite in the liver, distributes thro...

journal_title：Expert opinion on pharmacotherapy

authors： Doucette KE,Aoki FY

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Injection diclofenac sodium available at present as a 3-ml formulation is administered intragluteally. Standard needles may not reach the gluteus maximus muscle in many cases, especially in obese patients. Alternative sites like the deltoid have been suggested to be more suitable for these patients. Diclofena...

journal_title：Expert opinion on pharmacotherapy

authors： Ojha A,Shep D,Nivsarkar M,Patel S,Jaiswal V,Padh H

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Lysosomal storage disorders (LSDs) are clinically heterogeneous disorders that result primarily from lysosomal accumulation of macromolecules in various tissues. LSDs are always progressive, and often lead to severe symptoms and premature death. The identification of the underlying genetic and enzymatic de...

journal_title：Expert opinion on pharmacotherapy

authors： van Gelder CM,Vollebregt AA,Plug I,van der Ploeg AT,Reuser AJ

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:This comparison of PRAsugrel and clopidogrel in Japanese patients with ischemic STROke (PRASTRO)-I trial investigates the noninferiority of prasugrel to clopidogrel sulfate in the prevention of recurrence of primary events (ischemic stroke, myocardial infarction, and death from other vascular causes), and th...

journal_title：Expert opinion on pharmacotherapy

authors： Nagao T,Toyoda K,Kitagawa K,Kitazono T,Yamagami H,Uchiyama S,Tanahashi N,Matsumoto M,Minematsu K,Nagata I,Nishikawa M,Nanto S,Abe K,Ikeda Y,Ogawa A

更新日期：2018-04-01 00:00:00

abstract：:Ramipril is an angiotensin-converting enzyme inhibitor that has been extensively studied in randomised, controlled clinical trials in patients with cardiovascular diseases. Therapy with ramipril in patients with various cardiovascular disorders has demonstrated significant and clinically important reductions in cardio...

journal_title：Expert opinion on pharmacotherapy

authors： Rokoss MJ,Teo KK

更新日期：2005-09-01 00:00:00

abstract：INTRODUCTION:Convulsive status epilepticus (SE) is one of the most frequent and severe neurological emergencies in both adults and children. A timely administration of appropriate antiepileptic drugs (AEDs) can stop seizures early and markedly improve outcome. AREAS COVERED:The main treatment strategies for SE are rev...

journal_title：Expert opinion on pharmacotherapy

authors： Sánchez Fernández I,Loddenkemper T

更新日期：2015-03-01 00:00:00

abstract：INTRODUCTION:Chronic hepatitis C infection is a global disease with 160 million people infected worldwide. Until recently, therapy was characterized by long duration, suboptimal success rates and significant adverse drug reactions. The development of direct-acting antivirals initiated a dramatic change in the treatment...

journal_title：Expert opinion on pharmacotherapy

authors： Stirnimann G

更新日期：2014-12-01 00:00:00