The optimal combination therapy for the treatment of early rheumatoid arthritis.

abstract：INTRODUCTION:The bcr-abl tyrosine kinase inhibitors (TKIs) are the cornerstone treatment for chronic myeloid leukemia (CML). However, there are many topics related to therapy that remain debated. AREAS COVERED:The aim of this paper is to give the reader a comprehensive review of how to treat CML at diagnosis, how to m...

journal_title：Expert opinion on pharmacotherapy

authors： Tanaka MF,Kantarjian H,Cortes J,Ohanian M,Jabbour E

更新日期：2012-04-01 00:00:00

abstract：:Overweight, obesity and the metabolic syndrome occur in genetically susceptible individuals with environmental influences, and may be further compounded by other disorders of metabolism or pharmacological therapy that increase insulin resistance or promotes weight gain. Treatment of the metabolic syndrome should focus...

journal_title：Expert opinion on pharmacotherapy

authors： Stone NJ,Schmeltz LR

更新日期：2007-09-01 00:00:00

abstract：:Since the introduction of chlorpromazine in the 1950s, antipsychotics have been used for the treatment of schizophrenia. The phenothiazines were followed by the butyrophenones, particularly haloperidol. With all the movement disorder side effects of these medications (extrapyramidal syndrome, akathisia, tardive dyskin...

journal_title：Expert opinion on pharmacotherapy

authors： Kato MM,Goodnick PJ

更新日期：2001-10-01 00:00:00

abstract：:The treatment of acute decompensated heart failure (ADHF) remains a therapeutic challenge. Nesiritide was approved by the FDA in 2001 for the treatment of patients with ADHF who have dyspnea at rest or with minimal exertion. Although widely adopted for the treatment of ADHF due to its ability to decrease ventricular f...

journal_title：Expert opinion on pharmacotherapy

authors： Shah SJ,Teerlink JR

更新日期：2007-02-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic, autoimmune disease that has traditionally been treated with non-biologic and biologic disease-modifying antirheumatic drugs (DMARDs). Although these agents have become firmly established as effective RA treatments, some patients do not have an adequate response. The recent appro...

journal_title：Expert opinion on pharmacotherapy

authors： Lundquist LM

更新日期：2007-10-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Sitagliptin is a highly selective oral dipeptidyl peptidase-4 inhibitor. This drug increases the plasma concentration of active glucagon like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide. These two hormones then simulate the secretion of insulin in a glucose-dependent manner and inhibit glu...

journal_title：Expert opinion on pharmacotherapy

authors： Gagliardino JJ,Santoro S,Arellano S,Di Girolamo G

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:Panic disorder (PD) is a prevalent psychiatric disorder characterized by unexpected and recurrent panic attacks. PD patients present significant psychosocial impairment and a high risk of psychiatric comorbidities and suicide. PD should be treated effectively as soon as the symptoms emerge because the long...

journal_title：Expert opinion on pharmacotherapy

authors： Freire RC,Hallak JE,Crippa JA,Nardi AE

更新日期：2011-06-01 00:00:00

abstract：IMPORTANCE OF THE FIELD:Currently available small case reports clearly propose that existing regulatory procedures to approve generic versions only require essential bioequivalence, have limitations and fail to meet stricter scientific and clinical demands. AREAS COVERED IN THIS REVIEW:Data indicate that paroxetine me...

journal_title：Expert opinion on pharmacotherapy

authors： Pae CU,Misra A,Ham BJ,Han C,Patkar AA,Masand PS

更新日期：2010-02-01 00:00:00

abstract：:Seborrhoeic dermatitis (SD) is a recurrent, chronic inflammation of the skin that occurs on sebum rich areas such as the face, scalp and chest, characterised by red scaly lesions. The are many studies indicating that Malassezia yeasts play an important role in the aetiology of this condition, most of the evidence for ...

journal_title：Expert opinion on pharmacotherapy

authors： Gupta AK,Kogan N

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:PI3K inhibition with idelalisib (at that time CAL-101) was at the forefront of the development of molecularly targeted therapies in Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) and follicular lymphoma. However, after initial approval, subsequent trials identified specific immune-medi...

journal_title：Expert opinion on pharmacotherapy

authors： Kienle DL,Stilgenbauer S

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Miconazole (MCZ) is a time-honored antifungal of the imidazole class. MCZ exerts a multipronged effect on fungi. It inhibits the cytochrome P450 complex, including the 14α-demethylase enzyme required for ergosterol biosynthesis, in fungal cell membranes. In addition, intracellular accumulation of toxic met...

journal_title：Expert opinion on pharmacotherapy

authors： Piérard GE,Hermanns-Lê T,Delvenne P,Piérard-Franchimont C

更新日期：2012-06-01 00:00:00

abstract：:HIV-1/highly active antiretroviral therapy-associated lipodystrophy syndrome (HALS) is presently the most common long-term adverse effect limiting the doubtless efficacy of antiretroviral therapy. It has a great impact on the quality of life of patients, it is stigmatising and its psychologically devastating consequen...

journal_title：Expert opinion on pharmacotherapy

authors： del Mar Gutierrez M,Mateo G,Domingo P

更新日期：2007-08-01 00:00:00

abstract：INTRODUCTION:Alzheimer's disease (AD)-related epileptic comorbidity is now well documented and appears to have been previously underestimated. Prescribing antiepileptic drugs (AEDs) in AD patients aims at preventing seizure-related morbi-mortality and the occurrence of deleterious status epilepticus. At the earlier sta...

journal_title：Expert opinion on pharmacotherapy

authors： Cretin B

更新日期：2018-08-01 00:00:00

abstract：:Orlistat (Xenical, Hoffmann-La Roche) is a powerful inhibitor of gastrointestinal lipase and as such, reduces fat absorption. Unlike other weight-reducing drugs it is minimally absorbed and has no effects in the CNS. Orlistat is indicated for patients with a body mass index (BMI) of at least 30 kg/m2 or 28 kg/m2 in th...

journal_title：Expert opinion on pharmacotherapy

authors： Ballinger A

更新日期：2000-05-01 00:00:00

abstract：:The introduction of steroid therapy by Truelove and Witts in the 1950s revolutionized the treatment of ulcerative colitis. Corticosteroids are potent inhibitors of T-cell activation and proinflammatory cytokines and still represent the mainstay of therapy of patients with ulcerative colitis. About 15% of patients are ...

journal_title：Expert opinion on pharmacotherapy

authors： Bossa F,Colombo E,Andriulli A,Annese V

更新日期：2009-06-01 00:00:00

abstract：:Chronic kidney diseases frequently advance to end-stage renal failure, and the number of patients affected is steadily increasing worldwide. At the molecular level, progression of renal insufficiency correlates closely with ongoing pathological matrix protein expansion (i.e., renal fibrosis), in a manner independent o...

journal_title：Expert opinion on pharmacotherapy

authors： Gaedeke J,Neumayer HH,Peters H

更新日期：2006-03-01 00:00:00

abstract：:The orofacial complications of HIV infection are diverse, include opportunistic infection and malignancy and in many instances are region specific. Although effective management strategies to treat HIV-associated oral disease have been developed in North America and Europe, the evidence base on which these rely remain...

journal_title：Expert opinion on pharmacotherapy

authors： Hegarty AM,Chaudhry SI,Hodgson TA

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:BRAF inhibition alone has achieved unprecedented efficacy results in patients affected by BRAF-mutated advanced melanoma. Since these findings, it was postulated that dual inhibition of BRAF and other components of the RAS/RAF/MEK/ERK MAPK pathway (such as MEK) would be superior to BRAF inhibition as monot...

journal_title：Expert opinion on pharmacotherapy

authors： Richman J,Martin-Liberal J,Diem S,Larkin J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Miconazole nitrate is a time-honored antifungal of the imidazole class. OBJECTIVE:To revisit the various aspects of action of the drug in a dermatologic setting. METHOD:Review of the current peer-reviewed publications. RESULTS/CONCLUSION:Miconazole essentially inhibits 14alpha-demethylase, an enzyme requi...

journal_title：Expert opinion on pharmacotherapy

authors： Quatresooz P,Vroome V,Borgers M,Cauwenbergh G,Piérard GE

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Status Epilepticus (SE) is the most common neurological emergency of childhood. It requires prompt administration of appropriately selected anti-seizure medications. Areas covered: Following a distinction between estabilished and emergent drugs, we present pharmacological treatment options and their clinic...

journal_title：Expert opinion on pharmacotherapy

authors： Verrotti A,Ambrosi M,Pavone P,Striano P

更新日期：2017-06-01 00:00:00

abstract：INTRODUCTION:Metastatic prostate cancer is an incurable disease that is treated with a variety of hormonal therapies targeting various nodes of the androgen receptor (AR) pathway. Invariably patients develop resistance and become castration resistant. Common treatments for castration-resistant disease include novel hor...

journal_title：Expert opinion on pharmacotherapy

authors： Maughan BL,Antonarakis ES

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Treatment options for hair disorders are generally very limited. These options are even more limited in children due to the lack of trials and clinical research. Moreover, physicians are sometimes scared to treat children with drugs without safety data, especially because most hair disorders are benign. A...

journal_title：Expert opinion on pharmacotherapy

authors： Iorizzo M,Oranje AP

更新日期：2016-09-01 00:00:00

abstract：INTRODUCTION:Allergic rhinitis is a common condition with increasing prevalence and is associated with several comorbid disorders such as bronchial asthma and atopic dermatitis. If allergen avoidance is not possible, allergen-specific immunotherapy is the only causal treatment option. AREAS COVERED:This review focuses...

journal_title：Expert opinion on pharmacotherapy

authors： Klimek L,Sperl A,Becker S,Mösges R,Tomazic PV

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Management of a number of significant viral pathogens in transplant recipients remains challenging. OBJECTIVES:To define an optimal antiviral approach to the management of cytomegalovirus (CMV), human herpes virus-6 (HHV-6), Epstein-Barr (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), ...

journal_title：Expert opinion on pharmacotherapy

authors： Sun HY,Singh N

更新日期：2008-10-01 00:00:00

abstract：:One vaccine designed to prevent cancer by preventing a precursor infection is already in common use, and at least one more is in the latter stages of clinical development. These vaccines are part of a new era of cancer immunoprophylaxis. Several further vaccines are in preclinical and clinical development, targeted at...

journal_title：Expert opinion on pharmacotherapy

authors： Frazer I

更新日期：2004-12-01 00:00:00

abstract：INTRODUCTION:Treatment of rheumatoid arthritis (RA) has markedly advanced by the advent of biologic disease-modifying antirheumatic drugs (DMARDs). However, they require special storage and transportation and remission is observed in ∼ 30%. Tofacitinib inhibits the nonreceptor tyrosine kinase family Janus kinase (JAK),...

journal_title：Expert opinion on pharmacotherapy

authors： Yamaoka K,Tanaka Y

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is the leading cause of pain, loss of function and disability in the elderly, with the knee being the most impactful joint affected. Currently, there is still no 'cure' in OA treatment. AREAS COVERED:The authors review the current and emerging therapies for knee OA including traditiona...

journal_title：Expert opinion on pharmacotherapy

authors： Cao P,Li Y,Tang Y,Ding C,Hunter DJ

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:When estimating the cost-effectiveness or budget impact of chronic obstructive pulmonary disease (COPD) medication, it is common practice to use trial data for clinical inputs. However, such inputs do not always reflect the real-world situation. Previous reviews recognized the need for taking real-world da...

journal_title：Expert opinion on pharmacotherapy

authors： Fens T,Zhou G,Postma MJ,van Puijenbroek EP,van Boven JFM

更新日期：2021-01-13 00:00:00