Abatacept: a novel treatment for rheumatoid arthritis.

Abstract:

:Rheumatoid arthritis (RA) is a chronic, autoimmune disease that has traditionally been treated with non-biologic and biologic disease-modifying antirheumatic drugs (DMARDs). Although these agents have become firmly established as effective RA treatments, some patients do not have an adequate response. The recent approval of abatacept, a first-in-class agent that selectively modulates the activation of T cells, offers an alternative therapeutic option. As reflected in pharmacokinetic analyses, abatacept 10 mg/kg has been shown to be effective in treating patients with established RA. Demonstrating safety, efficacy and quality of life improvements in a wide range of RA patients, including those with inadequate response to methotrexate or tumor necrosis factor antagonists, abatacept is seen as a valuable addition to the RA treatment armamentarium.

authors

Lundquist LM

doi

10.1517/14656566.8.14.2371

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

2371-9

issue

14

eissn

1465-6566

issn

1744-7666

journal_volume

8

pub_type

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