Pharmacotherapy of post-transplant viral infections.

Abstract:

BACKGROUND:Management of a number of significant viral pathogens in transplant recipients remains challenging. OBJECTIVES:To define an optimal antiviral approach to the management of cytomegalovirus (CMV), human herpes virus-6 (HHV-6), Epstein-Barr (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), and polyoma virus-associated nephropathy in transplant recipients. METHODS:Clinical trials and existing data regarding use of antiviral agents for these viruses were reviewed to develop evidence-based recommendations for their management. CONCLUSIONS:Weighing the current evidence regarding the use of valganciclovir as pre-emptive therapy or prophylaxis, the former approach offers a greater benefit for the overall prevention of CMV disease. Limited data show that prophylaxis with antiviral agents is associated with a reduction in the risk of EBV-associated PTLD. Treatment options for HHV-6 and polyoma virus-associated nephropathy are still limited.

authors

Sun HY,Singh N

doi

10.1517/14656566.9.14.2409

subject

Has Abstract

pub_date

2008-10-01 00:00:00

pages

2409-21

issue

14

eissn

1465-6566

issn

1744-7666

journal_volume

9

pub_type

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