Pharmacological management of human respiratory syncytial virus infection.

abstract：:The objective of this article is to evaluate the roles of the lipid-lowering class of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) in reducing cardiovascular events and to review their mechanism of action based on in vitro and in vivo studies. The clinical outcome of 15 major clinical...

journal_title：Expert opinion on pharmacotherapy

authors： Moghadasian MH,Mancini GB,Frohlich JJ

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:PI3K inhibition with idelalisib (at that time CAL-101) was at the forefront of the development of molecularly targeted therapies in Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) and follicular lymphoma. However, after initial approval, subsequent trials identified specific immune-medi...

journal_title：Expert opinion on pharmacotherapy

authors： Kienle DL,Stilgenbauer S

更新日期：2020-06-01 00:00:00

abstract：:Staphylococcus aureus is a bacterial pathogen responsible for a variety of serious infections and is a frequent cause of nosocomial disease. During the last 60 years, S. aureus has developed increasing in vitro resistance to virtually all antimicrobials. In contrast, vancomycin has maintained a high degree of activity...

journal_title：Expert opinion on pharmacotherapy

authors： Pope SD,Roecker AM

更新日期：2007-06-01 00:00:00

abstract：INTRODUCTION:Docetaxel and paclitaxel are among the most active agents for the treatment of breast cancer. These first-generation taxanes are extremely hydrophobic; therefore, solvents are needed for its parenteral administration. Albumin nanoparticle technology allows for the transportation of such hydrophobic drugs w...

journal_title：Expert opinion on pharmacotherapy

authors： Guarneri V,Dieci MV,Conte P

更新日期：2012-02-01 00:00:00

abstract：INTRODUCTION:The pharmacotherapeutic management of depression in patients with multiple sclerosis (MS) is a matter of debate that cannot be decided from the evidence available in the current literature. Therefore, its management essentially relies on the clinical experience of the prescribing clinician rather than on e...

journal_title：Expert opinion on pharmacotherapy

authors： Carta MG,Paribello P,Anastasia A,De Berardis D,Nardi AE,Fornaro M

更新日期：2018-10-01 00:00:00

abstract：INTRODUCTION:Postpartum depression (PPD) is a common and serious illness that affects up to 14% of women in the first month after childbirth. We present an update on the pharmacologic treatment of PPD, although there continues to be a lack of large, randomized controlled trials (RCTs). AREAS COVERED:A review of the li...

journal_title：Expert opinion on pharmacotherapy

authors： Kim DR,Epperson CN,Weiss AR,Wisner KL

更新日期：2014-06-01 00:00:00

abstract：:Autism is a heterogeneous condition, currently with no single explanation for all of these findings presented at this conference. What conferences like this offer us, however, are possible courses of new research and the subsequent development of intervention strategies, both orthodox (pharmacological) and perhaps sli...

journal_title：Expert opinion on pharmacotherapy

authors： Whiteley P

更新日期：2001-07-01 00:00:00

abstract：:Acinetobacter baumannii is an important cause of nosocomial infections, mainly in patients in intensive care units. This microorganism, although with slight differences depending on the country, presents resistance to multiple antimicrobial agents, occasionally including resistance to colistin: hence, it can be consid...

journal_title：Expert opinion on pharmacotherapy

authors： Vila J,Pachón J

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Management of a number of significant viral pathogens in transplant recipients remains challenging. OBJECTIVES:To define an optimal antiviral approach to the management of cytomegalovirus (CMV), human herpes virus-6 (HHV-6), Epstein-Barr (EBV)-associated post-transplant lymphoproliferative disorder (PTLD), ...

journal_title：Expert opinion on pharmacotherapy

authors： Sun HY,Singh N

更新日期：2008-10-01 00:00:00

abstract：:Clopidogrel has become a mainstay in the management of acute coronary syndrome patients over the past decade, as well as an essential component of percutaneous coronary intervention (PCI) pharmacotherapy. Until recently, no prospective study has evaluated the effectiveness of clopidogrel in the setting of an ST-segmen...

journal_title：Expert opinion on pharmacotherapy

authors： Hamdalla H,Moliterno DJ

更新日期：2006-08-01 00:00:00

abstract：:The incidence of nucleoside analogue-related lactic acidosis has been estimated in 0.57 - 8.5 cases/1000 person years of antiretroviral therapy. The onset of lactic acidosis is usually insidious and patients complain of nausea, vomiting, abdominal pain, fatigue and weight loss. When lactate levels are high enough, a c...

journal_title：Expert opinion on pharmacotherapy

authors： Falcó V,Crespo M,Ribera E

更新日期：2003-08-01 00:00:00

abstract：OBJECTIVE:Beta-lactamase producing bacteria present a major problem in treating lower respiratory tract infections. The objective of this study was to evaluate efficacy and safety of cefotaxime-sulbactam combination versus amoxicillin-clavulanic acid injection as an alternative therapeutic option for treatment of lower...

journal_title：Expert opinion on pharmacotherapy

authors： Pareek A,Kulkarni M,Daga S,Deshpande A,Chandurkar N

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Combination of glibenclamide (glyburide in the U.S.) and metformin hydrochloride simultaneously addresses two different but complimentary mechanisms to improve glycemic control in type 2 diabetes. AREAS COVERED:The pharmacokinetics, efficacy, and side effect profile of the oral combination of glibenclamid...

journal_title：Expert opinion on pharmacotherapy

authors： Lamos EM,Stein SA,Davis SN

更新日期：2012-12-01 00:00:00

abstract：INTRODUCTION:Colorectal cancer (CRC) is the third most common cancer in the western world and also in Japan. The key factors in curing CRC are early detection, surgery and adequate adjuvant chemotherapy if needed. AREAS COVERED:Based on the results of following pivotal adjuvant trials, FOLFOX or XELOX are considered s...

journal_title：Expert opinion on pharmacotherapy

authors： Tsuji Y,Sugihara K

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:In the 40-50% of advanced melanoma patients with tumors harboring BRAF V600E and V600 K mutations, BRAF inhibitors such as dabrafenib are a highly effective treatment. However, most patients develop resistance after several months on treatment. The addition of a MEK inhibitor, such as trametinib, to BRAF i...

journal_title：Expert opinion on pharmacotherapy

authors： Spain L,Julve M,Larkin J

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Many patients with type 2 diabetes mellitus (T2DM) fail to achieve the desired A1c goal because the antidiabetic medications used do not correct the underlying pathophysiologic abnormalities and monotherapy is not sufficiently potent to reduce the A1c to the 6.5 - 7.0% range. Insulin resistance and islet (...

journal_title：Expert opinion on pharmacotherapy

authors： Triplitt C,Solis-Herrera C,Cersosimo E,Abdul-Ghani M,Defronzo RA

更新日期：2015-01-01 00:00:00

abstract：:Glycosuria is being increasingly recognised as not only a symptom but also as a novel therapeutic approach in the management of type 2 diabetes mellitus (T2DM). This is accomplished through sodium glucose co-transporter 2 (SGLT2) inhibitors. Consequently, the safety and efficacy of these new agents have been thoroughl...

journal_title：Expert opinion on pharmacotherapy

authors： Pafili K,Papanas N

更新日期：2015-03-01 00:00:00

abstract：:Orlistat (Xenical, Hoffmann-La Roche) is a powerful inhibitor of gastrointestinal lipase and as such, reduces fat absorption. Unlike other weight-reducing drugs it is minimally absorbed and has no effects in the CNS. Orlistat is indicated for patients with a body mass index (BMI) of at least 30 kg/m2 or 28 kg/m2 in th...

journal_title：Expert opinion on pharmacotherapy

authors： Ballinger A

更新日期：2000-05-01 00:00:00

abstract：INTRODUCTION:Obstructive sleep apnea syndrome is a common public health problem in the general population. The important health-related consequences of obstructive sleep apnea include cardiovascular disorders, such as myocardial infarction and hypertension, stroke, sudden death and difficult blood sugar control related...

journal_title：Expert opinion on pharmacotherapy

authors： Lin CM,Huang YS,Guilleminault C

更新日期：2012-04-01 00:00:00

abstract：:A systemic and endemic emerging mycosis in Latin America, paracoccidioidomycosis, is characterised by its chronicity and by the severity of the disseminated form in healthy individuals, as well as in immunocompromised individuals co-infected with HIV, resulting, in the latter, in a mortality rate in the range of 30 - ...

journal_title：Expert opinion on pharmacotherapy

authors： Yasuda MA

更新日期：2005-03-01 00:00:00

abstract：INTRODUCTION:Migraine is a common and highly disabling neurological disorder whose acute treatment remains problematic and unsatisfactory in a high percentage of cases. Consequently, there remains a need for new symptomatic therapies that can be easily handled by patients (i.e. by oral administration). AREAS COVERED:T...

journal_title：Expert opinion on pharmacotherapy

authors： Martelletti P,Giamberardino MA

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Prescription omega-3-acid ethyl esters (P-OM3) have been used as adjunctive therapy to statin drugs in patients with mixed hyperlipidemia. OBJECTIVE:To assess the effect of concomitant administration of 4 g P-OM3 on the steady-state pharmacokinetics of the maximum recommended daily dose of atorvastatin (80 ...

journal_title：Expert opinion on pharmacotherapy

authors： Di Spirito M,Morelli G,Doyle RT,Johnson J,McKenney J

更新日期：2008-12-01 00:00:00

abstract：INTRODUCTION:Disturbances in lipid metabolism represent an integral component of dysglycemic states and may increase the risk of diabetic complications. Although from a pathophysiological viewpoint fibrates could represent the ideal drug for patients with diabetic dyslipidemia the evidence that support their use in the...

journal_title：Expert opinion on pharmacotherapy

authors： Tsimihodimos V,Mikhailidis DP,Elisaf M

更新日期：2013-12-01 00:00:00

abstract：:Phosphorus binders are used in patients with kidney failure because of the incomplete removal of phosphorus with dialysis and the inability to exclude phosphorus from the diet. Aluminium was the initial phosphorus binder used, but was replaced by calcium-containing binders because of the development of aluminium toxic...

journal_title：Expert opinion on pharmacotherapy

authors： Bleyer AJ

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of sodium glucose co-transporter 2 inhibitors in non-obese compared with obese patients with type 2 diabetes mellitus is unknown. METHODS:We conducted post hoc analyses of the results of a 52-week open-label study of Japanese type 2 diabetes mellitus patients treated with 100 or 200 ...

journal_title：Expert opinion on pharmacotherapy

authors： Inagaki N,Goda M,Yokota S,Maruyama N,Iijima H

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Atherosclerosis is frequently caused by clot blockage of the coronary or peripheral arteries, and may lead to myocardial infarction (MI) or peripheral arterial disease (PAD). Despite advancements in management of atherosclerosis, mortality and ischemic rates remain high. Vorapaxar is a protease activated r...

journal_title：Expert opinion on pharmacotherapy

authors： Wang A

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Incomplete remission and treatment resistance are common even in first-episode psychosis patients. OBJECTIVE:The aim of this review was to provide an overview of the available interventions and treatment pathways for the management of incomplete remission and treatment resistance in first-episode psychosis....

journal_title：Expert opinion on pharmacotherapy

authors： Lambert M,Naber D,Huber CG

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:Meropenem-vaborbactam is a new beta-lactam/beta-lactamase inhibitor combination that combines a carbapenem antibiotic with a first-in-class, boronic acid pharmacophore, serine beta-lactamase inhibitor which has potent inhibitory activity against class A carbapenemases, especially Klebsiella pneumoniae carb...

journal_title：Expert opinion on pharmacotherapy

authors： Wu G,Cheon E

更新日期：2018-09-01 00:00:00

abstract：:The long-term beta-blockade strategy with carvedilol, metoprolol succinate or bisoprolol is now strongly recommended to reduce the rates of mortality and morbidity in patients with chronic heart failure (CHF). Although the benefits observed with such drugs are viewed as a class effect, theoretically, carvedilol might ...

journal_title：Expert opinion on pharmacotherapy

authors： Di Lenarda A,Sabbadini G,Moretti M,Sinagra G

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVES:In 1991, small cell lung cancer (SCLC) was reported as the first tumour type where colony stimulating factor (CSF) support was clinically effective. We reviewed 13 health services research studies that addressed CSF use as supportive care for SCLC. METHODS:Findings from American Society of Clinical Oncology...

journal_title：Expert opinion on pharmacotherapy

authors： Adams JR,Lyman GH,Djubegovic B,Feinglass J,Bennett CL

更新日期：2002-09-01 00:00:00