Comparative Analysis of Gut Microbial Communities in Children under 5 Years Old with Diarrhea.

Abstract:

:Diarrhea is a global disease with a high morbidity and mortality rate in children. In this study, 25 fecal samples were collected from children under 5 years old. Seven samples had been taken from healthy children without diarrhea and marked as the healthy control group; eight samples had been sampled from children with diarrhea caused by dyspepsia and defined as the non-infectious group; and ten samples had been taken from children with diarrhea induced by intestinal infections and identified as the infectious group. We detected the microbial communities of samples by using high-throughput sequencing of 16S rRNA genes. The proportion of aerobic and facultative anaerobic microbes in samples of the infectious group was much higher than in the non-infectious group. In addition, the relative abundance of Enterococcus in the healthy control group was significantly higher than in the non-infectious group and infectious group. This can be used as a potential diagnostic biomarker for diarrhea.

journal_name

J Microbiol Biotechnol

authors

Wen H,Yin X,Yuan Z,Wang X,Su S

doi

10.4014/jmb.1711.11065

subject

Has Abstract

pub_date

2018-04-28 00:00:00

pages

652-662

issue

4

eissn

1017-7825

issn

1738-8872

pii

10.4014/jmb.1711.11065

journal_volume

28

pub_type

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