Abstract：
:The neuromodulator serotonin (5-HT) has been implicated in a variety of functions that involve patience or impulse control. Many of these effects are consistent with a long-standing theory that 5-HT promotes behavioral inhibition, a motivational bias favoring passive over active behaviors. To further test this idea, we studied the impact of 5-HT in a probabilistic foraging task, in which mice must learn the statistics of the environment and infer when to leave a depleted foraging site for the next. Critically, mice were required to actively nose-poke in order to exploit a given site. We show that optogenetic activation of 5-HT neurons in the dorsal raphe nucleus increases the willingness of mice to actively attempt to exploit a reward site before giving up. These results indicate that behavioral inhibition is not an adequate description of 5-HT function and suggest that a unified account must be based on a higher-order function.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Lottem E,Banerjee D,Vertechi P,Sarra D,Lohuis MO,Mainen ZFdoi
10.1038/s41467-018-03438-ysubject
Has Abstractpub_date
2018-03-08 00:00:00pages
1000issue
1issn
2041-1723pii
10.1038/s41467-018-03438-yjournal_volume
9pub_type
杂志文章abstract：:Alike materials in the solid state, the phase diagram of type-II superconductors exhibit crystalline, amorphous, liquid and spatially inhomogeneous phases. The multitude of different phases of vortex matter has thence proven to act as almost ideal model system for the study of both the underlying properties of superco...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9813
更新日期：2015-11-02 00:00:00
abstract：:The functional organization of the hippocampus is distributed as a gradient along its longitudinal axis that explains its differential interaction with diverse brain systems. We show that the location of human tissue samples extracted along the longitudinal axis of the adult human hippocampus can be predicted within 2...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-14518-3
更新日期：2020-02-19 00:00:00
abstract：:Blue/deep-blue emission is crucial for organic optoelectronics but remains a formidable challenge in organic afterglow due to the difficulties in populating and stabilizing the high-energy triplet excited states. Here, a facile strategy to realize the efficient deep-blue organic afterglow is proposed via host molecule...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-18572-9
更新日期：2020-09-23 00:00:00
abstract：:Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-19492-4
更新日期：2020-11-06 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) contribute to cardiac (patho)physiology. Aging is the major risk factor for cardiovascular disease with cardiomyocyte apoptosis as one underlying cause. Here, we report the identification of the aging-regulated lncRNA Sarrah (ENSMUST00000140003) that is anti-apoptotic in cardiomyocytes. ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-15995-2
更新日期：2020-04-27 00:00:00
abstract：:Circadian clocks generate reliable ~24-h rhythms despite being based on stochastic biochemical reactions. The circadian clock in Synechococcus elongatus uses a post-translational oscillator that cycles deterministically in a test tube. Because the volume of a single bacterial cell is much smaller than a macroscopic re...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05109-4
更新日期：2018-08-01 00:00:00
abstract：:The worldwide prevalence of infections caused by antibiotic-resistant Gram-negative bacteria poses a serious threat to public health due to the limited therapeutic alternatives. Cationic peptides represent a large family of antibiotics and have attracted interest due to their diverse chemical structures and potential ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-05781-6
更新日期：2018-08-16 00:00:00
abstract：:Drought comprehensively affects different interlinked aspects of the terrestrial water cycle, which have so far been mostly investigated without direct comparison. Resolving the partitioning of water deficit during drought into blue-water runoff and green-water evapotranspiration fluxes is critical, as anomalies in th...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-06013-7
更新日期：2018-09-06 00:00:00
abstract：:Anthropogenic CO2 emissions are causing ocean acidification, which can affect the physiology of marine organisms. Here we assess the possible effects of ocean acidification on the metabolic potential of sponge symbionts, inferred by metagenomic analyses of the microbiomes of two sponge species sampled at a shallow vol...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-12156-y
更新日期：2019-09-12 00:00:00
abstract：:Brain-inspired parallel computing, which is typically performed using a hardware neural-network platform consisting of numerous artificial synapses, is a promising technology for effectively handling large amounts of informational data. However, the reported nonlinear and asymmetric conductance-update characteristics ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17849-3
更新日期：2020-08-07 00:00:00
abstract：:Self-assembly of proteins and inorganic nanoparticles into terminal assemblies makes possible a large family of uniformly sized hybrid colloids. These particles can be compared in terms of utility, versatility and multifunctionality to other known types of terminal assemblies. They are simple to make and offer theoret...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms4593
更新日期：2014-05-20 00:00:00
abstract：:During animal cell division, the central spindle, an anti-parallel microtubule bundle structure formed between segregating chromosomes during anaphase, cooperates with astral microtubules to position the cleavage furrow. Because the central spindle is the only structure linking the two halves of the mitotic spindle, i...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms8290
更新日期：2015-06-19 00:00:00
abstract：:The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR st...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms6383
更新日期：2014-11-21 00:00:00
abstract：:Development of on-chip integrated carbon-based optoelectronic nanocircuits requires fast and non-invasive structural characterization of their building blocks. Recent advances in synthesis of single wall carbon nanotubes and graphene nanoribbons allow for their use as atomically precise building blocks. However, while...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-019-13728-8
更新日期：2020-01-03 00:00:00
abstract：:Fusion proteins containing blue-light-activable protein domains possess great potential as molecular switches in cell signalling. This has recently been impressively demonstrated by connecting the light oxygen voltage LOV2-Jα-protein domain of A. sativa (AsLOV2-Jα) with the Rac1-GTPase, responsible for regulating the ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms1121
更新日期：2010-11-16 00:00:00
abstract：:Trade-offs play an important role in evolution. Without trade-offs, evolution would maximize fitness of all traits leading to a "master of all traits". The shape of trade-offs has been shown to determine evolutionary trajectories and is often assumed to be static and independent of the actual evolutionary process. Her...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-01957-8
更新日期：2017-12-12 00:00:00
abstract：:Soliton microcombs constitute chip-scale optical frequency combs, and have the potential to impact a myriad of applications from frequency synthesis and telecommunications to astronomy. The demonstration of soliton formation via self-injection locking of the pump laser to the microresonator has significantly relaxed t...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20196-y
更新日期：2021-01-11 00:00:00
abstract：:The original version of this Article contained an error in the spelling of the author Woochul Song, which was incorrectly given as Woochul C. Song. This has been corrected in both the PDF and HTML versions of the Article. ...
journal_title：Nature communications
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41467-018-05447-3
更新日期：2018-08-14 00:00:00
abstract：:Hepatitis B virus causes chronic infections in 250 million people worldwide. Chronic hepatitis B virus carriers are at risk of developing fibrosis, cirrhosis, and hepatocellular carcinoma. A prophylactic vaccine exists and currently available antivirals can suppress but rarely cure chronic infections. The study of hep...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-017-00200-8
更新日期：2017-07-25 00:00:00
abstract：:Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic osteosarcoma lesions, 11 major cell clusters are identified based on unbiased clustering of gene expression profiles and canonical markers. The...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-20059-6
更新日期：2020-12-10 00:00:00
abstract：:Inorganic perovskites such as CsPbX3 (X=Cl, Br, I) have attracted attention due to their excellent thermal stability and high photoluminescence quantum efficiency. However, the electroluminescence quantum efficiency of their light-emitting diodes was <1%. We posited that this low efficiency was a result of high leakag...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms15640
更新日期：2017-06-07 00:00:00
abstract：:The low-energy elementary excitations in frustrated quantum magnets have fascinated researchers for decades. In frustrated Ising magnets on a pyrochlore lattice possessing macroscopically degenerate spin-ice ground states, the excitations have been discussed in terms of classical magnetic monopoles, which do not conta...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10807
更新日期：2016-02-25 00:00:00
abstract：:The time-dependent response of structural materials dominates our aging infrastructure's life expectancy and has important resilience implications. For calcium-silicate-hydrates, the glue of cement, nanoscale mechanisms underlying time-dependent phenomena are complex and remain poorly understood. This complexity origi...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-04174-z
更新日期：2018-05-03 00:00:00
abstract：:Quintulene, a non-graphitic cycloarene with fivefold symmetry, has remained synthetically elusive due to its high molecular strain originating from its curved structure. Here we report the construction of extended quintulene, which was unambiguously characterized by mass and NMR spectroscopy. The extended quintulene r...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-020-17691-7
更新日期：2020-08-07 00:00:00
abstract：:The superconducting gap structure in iron-based high-temperature superconductors (Fe-HTSs) is non-universal. In contrast to other unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries are close in energy. Probing the proximity between these very different superconducting sta...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9863
更新日期：2015-11-09 00:00:00
abstract：:Ultrasound sensors have wide applications across science and technology. However, improved sensitivity is required for both miniaturisation and increased spatial resolution. Here, we introduce cavity optomechanical ultrasound sensing, where dual optical and mechanical resonances enhance the ultrasound signal. We achie...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/s41467-018-08038-4
更新日期：2019-01-10 00:00:00
abstract：:The efficiency of an heat engine is traditionally defined as the ratio of its average output work over its average input heat. Its highest possible value was discovered by Carnot in 1824 and is a cornerstone concept in thermodynamics. It led to the discovery of the second law and to the definition of the Kelvin temper...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms5721
更新日期：2014-09-15 00:00:00
abstract：:Anterior pituitary is critical for endocrine systems. Its hormonal responses to positive and negative regulators are indispensable for homeostasis. For this reason, generating human anterior pituitary tissue that retains regulatory hormonal control in vitro is an important step for the development of cell transplantat...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms10351
更新日期：2016-01-14 00:00:00
abstract：:Metal ions can serve as a centre of molecular motions due to their coordination geometry, reversible bonding nature and external stimuli responsiveness. Such essential features of metal ions have been utilized for metal-mediated molecular machines with the ability to motion switch via metallation/demetallation or coor...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms14296
更新日期：2017-02-08 00:00:00
abstract：:Horizontal gene transfer is a major contributor to the evolution of bacterial genomes and can facilitate the dissemination of antibiotic resistance genes between environmental reservoirs and potential pathogens. Wastewater treatment plants (WWTPs) are believed to play a central role in the dissemination of antibiotic ...
journal_title：Nature communications
pub_type： 杂志文章
doi：10.1038/ncomms9452
更新日期：2015-09-30 00:00:00
