Abstract：
:Remote patient monitoring should reduce mortality rates, improve care, and reduce costs. We present an overview of the available technologies for the remote monitoring of chronic obstructive pulmonary disease (COPD) patients, together with the most important medical information regarding COPD in a language that is adapted for engineers. Our aim is to bridge the gap between the technical and medical worlds and to facilitate and motivate future research in the field. We also present a justification, motivation, and explanation of how to monitor the most important parameters for COPD patients, together with pointers for the challenges that remain. Additionally, we propose and justify the importance of electrocardiograms (ECGs) and the arterial carbon dioxide partial pressure (PaCO2) as two crucial physiological parameters that have not been used so far to any great extent in the monitoring of COPD patients. We cover four possibilities for the remote monitoring of COPD patients: continuous monitoring during normal daily activities for the prediction and early detection of exacerbations and life-threatening events, monitoring during the home treatment of mild exacerbations, monitoring oxygen therapy applications, and monitoring exercise. We also present and discuss the current approaches to decision support at remote locations and list the normal and pathological values/ranges for all the relevant physiological parameters. The paper concludes with our insights into the future developments and remaining challenges for improvements to continuous remote monitoring systems. Graphical abstract ᅟ.
journal_name
Med Biol Eng Computjournal_title
Medical & biological engineering & computingauthors
Tomasic I,Tomasic N,Trobec R,Krpan M,Kelava Tdoi
10.1007/s11517-018-1798-zsubject
Has Abstractpub_date
2018-04-01 00:00:00pages
547-569issue
4eissn
0140-0118issn
1741-0444pii
10.1007/s11517-018-1798-zjournal_volume
56pub_type
杂志文章,评审abstract：:The energy storage capacity of the human foot as a passive structure depends on both its geometry and elastic properties. The present study examines theoretically the relationship between the energy stored in the longitudinal arch and the inclination of the calcaneus, when a vertical load is applied. A simple two-dime...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441770
更新日期：1990-03-01 00:00:00
abstract：:Soleus muscle flap as coverage tissue is a possible surgical solution adopted to cover the wounds due to open fractures. Despite this procedure presents many clinical advantages, relatively poor information is available about the loss of functionality of triceps surae of the treated leg. In this study, a group of pati...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-020-02286-7
更新日期：2021-01-01 00:00:00
abstract：:A three-dimensional model of myocardial tissue has been developed which incorporates electrotonic interactions between neighbouring myocytes. The algorithms of the model are based on asynchronous planning of discrete events. Each cellular element is described in a logical way and traces a predefined action potential w...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441665
更新日期：1991-07-01 00:00:00
abstract：:The paper explains the application of a genetic algorithm (GA) to the problem of estimating parameters for a kinetic model of a biologically reacting system. It is demonstrated that the GA is a powerful tool for quantifying the kinetic parameters using kinetic data. As the operation of the GA does not depend on the fo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02510391
更新日期：1997-01-01 00:00:00
abstract：:In this paper, delivery devices for nanosecond pulsed electric field exposure of biological samples in direct contact with electrodes or isolated are presented and characterized. They are based on a modified electroporation cuvette and two transverse electromagnetic cells (TEM cells). The devices were used to apply pu...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1676-0
更新日期：2018-01-01 00:00:00
abstract：:The boundary-element method (BEM) is widely used for electrocardiogram (ECG) simulation. Its major disadvantage is its perceived inability to deal with the anisotropic electric conductivity of the myocardial interstitium, which led researchers to represent only intracellular anisotropy or neglect anisotropy altogether...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-009-0472-x
更新日期：2009-07-01 00:00:00
abstract：:The aim of the study was to compare experimentally conduction velocity (CV) estimates obtained with different estimation methods based on surface electromyogram (EMG) signals detected using five spatial filters. The filters investigated were the longitudinal single and double differential, transverse single and double...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02348440
更新日期：2003-05-01 00:00:00
abstract：:A generic framework for the automated classification of human movements using an accelerometry monitoring system is introduced. The framework was structured around a binary decision tree in which movements were divided into classes and subclasses at different hierarchical levels. General distinctions between movements...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02347551
更新日期：2004-09-01 00:00:00
abstract：:There is multiple evidence in the literature that a sub-threshold pre-pulse, delivered immediately prior to an electrical stimulation pulse, can alter the activation threshold of nerve fibers and motor unit recruitment characteristics. So far, previously published works combined monophasic stimuli with sub-threshold d...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1851-y
更新日期：2018-12-01 00:00:00
abstract：:We present a new, automatic, correlation-based method for measuring the duration of motor unit action potentials (MUAPs). The method seeks to replicate the way an expert elctromyographer uses his or her eyes, calculating the start and end of the MUAP waveform on the basis of the degree of similarity of non-excluded di...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02115-6
更新日期：2020-03-01 00:00:00
abstract：:Detailed finite element (FE) models are used as promising tools to investigate traumatic brain injuries, although their accuracy is strongly dependent on the characterization of the mechanical behaviors of the different anatomic structures in the brain. In some cases, when the FE models require finer spatial resolutio...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1891-3
更新日期：2019-03-01 00:00:00
abstract：:Self-generated mobility is a major contributor to the physical, emotional, cognitive, and social development of infants and toddlers. When young children have disorders that hinder self locomotion, their development is at risk for delay. Independent mobility via traditional power mobility devices may prevent this dela...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0820-5
更新日期：2011-10-01 00:00:00
abstract：:Global field synchronization (GFS) quantifies the synchronization level of brain oscillations. The GFS method has been introduced to measure functional synchronization of EEG data in the frequency domain. GFS also detects phase interactions between EEG signals acquired from all of the electrodes. If a considerable amo...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-017-1689-8
更新日期：2018-02-01 00:00:00
abstract：:Due to its capabilities in analysing injury risk, the ability to analyse an athlete's ground reaction force and joint moments is of high interest in sports biomechanics. However, using force plates for the kinetic measurements influences the athlete's performance. Therefore, this study aims to use a feed-forward neura...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02000-2
更新日期：2019-08-01 00:00:00
abstract：:A hydrodynamic model for the part of the human arterial network below the renal arteries has been constructed using specially fabricated distensible tubes and a pulsatile pump to simulate an aortoiliac bypass. The experiments and the computer model indicated that no 'steal' occurred due to the insertion of the bypass ...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02441802
更新日期：1993-11-01 00:00:00
abstract：:A method for the identification of the breast boundary in mammograms is presented. The method can be used in the preprocessing stage of a system for computer-aided diagnosis (CAD) of breast cancer and also in the reduction of image file size in picture archiving and communication system applications. The method starte...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02344632
更新日期：2004-03-01 00:00:00
abstract：:Very few computer models of the spine integrate vertebral growth plates to investigate their mechanical behavior and potential impacts on bone growth. An approach was developed to generate a finite element (FE) model of the lumbar spine and their connective tissues including the growth plate, which allowed a personali...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-007-0220-z
更新日期：2007-10-01 00:00:00
abstract：:Widespread misconceptions still exist regarding the formation of extracellular potentials over the innervation zone: the assumption (1) that the first phase of these potentials mainly reflects the process of initiation of the intracellular action potential (IAP) at the neuromuscular junction and that (2) these potenti...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1487-8
更新日期：2016-12-01 00:00:00
abstract：:In this paper, the limitations of the conventional formula for the computation of peripheral blood flow from impedance plethysmograms are highlighted, and a correction to the formula is suggested. A conductivity cell experiment is described to show the dependence of the value of the blood flow index (BFI), obtained fr...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02524237
更新日期：1994-11-01 00:00:00
abstract：:It is of great importance to effectively process and interpret surface electromyogram (sEMG) signals to actuate a robotic and prosthetic exoskeleton hand needed by hand amputees. In this paper, we have proposed a cepstrum analysis-based method for classification of basic hand movement sEMG signals. Cepstral analysis t...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-02024-8
更新日期：2019-10-01 00:00:00
abstract：:The alpha angle is a parameter extensively used to assess for cam-type femoroacetabular impingement (FAI) in a 2D image of the hip. As this angle requires estimation of the axis of the femoral neck, the drawing of this axis often results in measurement errors due to subjective judgment, influencing inter-rater and int...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-019-01973-4
更新日期：2019-07-01 00:00:00
abstract：:We estimated the dynamic cell metabolic activity and the distribution of the pH value and oxygen concentration in tissue samples cultured in vitro by using real-time sensor records and a numerical simulation of the underlying reaction-diffusion processes. As an experimental tissue model, we used chicken spleen slices....
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-015-1367-7
更新日期：2016-05-01 00:00:00
abstract：:A new technique is derived for estimating the conduction velocity of muscle fibre action potentials from surface EMG recordings in humans. The method is based on system identification and extends previous such methods by explicitly accounting for additive noise at the output as well as at the input. Experimental and s...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02446220
更新日期：1989-03-01 00:00:00
abstract：:In the PREVENIR-5 study, artificial neural networks (NN) were applied to a large sample of patients with recent first acute coronary syndrome (ACS) to identify determinants of persistence of evidence-based cardiovascular medications (EBCM: antithrombotic + beta-blocker + statin + angiotensin converting enzyme inhibito...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-011-0785-4
更新日期：2011-08-01 00:00:00
abstract：:Spinal pattern generators (SPGs), which are neural networks without a central input from the brain may be responsible for controlling locomotion. In this study, we used neural oscillators to examine the rhythmic patterns generated at the ankle during walking. Seven healthy male subjects were requested to walk at their...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-012-0944-2
更新日期：2012-09-01 00:00:00
abstract：:The aim of the study is to determine the effects of wound, patient and treatment attributes on the wound healing rate and to propose a system for wound healing rate prediction. Predicting the wound healing rate from the initial wound, patient and treatment data collected in a database of 300 chronic wounds is not poss...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/BF02345144
更新日期：2001-09-01 00:00:00
abstract：:A mathematical model has been developed to facilitate indirect measurements of difficult to measure variables of the human energy metabolism on a daily basis. The model performs recursive system identification of the parameters of the metabolic model of the human energy metabolism using the law of conservation of ener...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-016-1552-3
更新日期：2017-05-01 00:00:00
abstract：:The purpose of this study is to investigate the change in biomechanical milieu following removal of pedicle screws in instrumented single level lumbar arthrodesis. Using a validated finite element (FE) model of the intact lumbar spine (L2-5), two scenarios of L3-4 lumbar fusion were simulated: posterolateral fusion (P...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-010-0621-2
更新日期：2010-07-01 00:00:00
abstract：:Selective laser sintering (SLS) is a solid freeform fabrication technique, developed by Carl Deckard for his master's thesis at the University of Texas, patented in 1989. SLS manufacturing is a technique that produces physical models through a selective solidification of a variety of fine powders. SLS technology is ge...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章,评审
doi：10.1007/s11517-012-1001-x
更新日期：2013-03-01 00:00:00
abstract：:In a computer-aided diagnosis (CAD) system, especially for chest radiograph or chest X-ray (CXR) screening, CXR image view information is required. Automatically separating CXR image view, frontal and lateral can ease subsequent CXR screening process, since the techniques may not equally work for both views. We presen...
journal_title：Medical & biological engineering & computing
pub_type： 杂志文章
doi：10.1007/s11517-018-1786-3
更新日期：2018-08-01 00:00:00
