Abstract:
:Sporotrichosis is a serious public health problem in Brazil that affects human patients and domestic animals, mainly cats. Thus, the search for new antifungal agents is required also due to the emergence and to the lack of effective drugs available in the therapeutic arsenal. The aim of this study was to evaluate the in vitro antifungal profile of two synthetic series of coumarin derivatives against Sporothrix schenckii and Sporothrix brasiliensis. The three-components synthetic routes used for the preparation of coumarin derivatives have proved to be quite efficient and compounds 16 and 17 have been prepared in good yields. The inhibitory activity of nineteen synthetic coumarins derivatives 16a-i and 17a-j were evaluated against Sporothrix spp. yeasts and the most potent compounds were 16b and 17i. However, according to concentrations able to inhibit (minimum inhibitory concentrations) and kill (minimum fungicidal concentrations) the cells, 17i was more effective than 16b against Sporothrix spp. Thus, 17i exhibited good antifungal activity against S. brasiliensis and S. schenckii, suggesting that it is an important scaffold for the development of novel antifungal agents.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
da S M Forezi L,Borba-Santos LP,Cardoso MFC,Ferreira VF,Rozental S,de C da Silva Fdoi
10.2174/1568026618666180221115508subject
Has Abstractpub_date
2018-01-01 00:00:00pages
164-171issue
2eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-88700journal_volume
18pub_type
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