Abstract:
BACKGROUND:Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the World Health Organization. There is hardly any FDA approved anti-Zika viral drugs available. OBJECTIVE:Therefore, it is a big panic for the scientists to destroy the virus completely by generating potent inhibitors. METHODS:For the purpose, various Zika viral targets were explored by structure-based design in the present review in connection with the discovery of various synthetic and natural sourced inhibitors against Zika virus. RESULTS:The structure-based drug design tools such as x-ray crystallography and molecular docking reported various co-crystallized ligands and Zika virus inhibitors. CONCLUSION:Such inhibitors could further be modified for the design of highly active leads to combat Zika virus utilizing chemoinformatics modules.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Nandi S,Kaur R,Kumar M,Sharma A,Naaz A,Mandal SCdoi
10.2174/1568026619666181120125525subject
Has Abstractpub_date
2018-01-01 00:00:00pages
1792-1803issue
20eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-94684journal_volume
18pub_type
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journal_title:Current topics in medicinal chemistry
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abstract:: ...
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