Abstract:
:The serotonin receptor subtype 5 HT(1A) was one of the first serotonin receptor subtypes pharmacologically characterized. Over the last twenty years the 5 HT(1A) receptor has been the object of intense research efforts as witnessed by the 5 HT(1A) acting drugs marketed as anxiolytics. In recent years, several new chemical entities targeting the 5 HT(1A) receptor (alone or in combination with other molecular targets) have been proposed for novel therapeutic indications (neuroprotection, cognitive impairment, Parkinson Disease and related disorders, pain treatment). The present review will focus on those 5 HT(1A) receptor agents that entered preclinical trials starting from 2000.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Lacivita E,Leopoldo M,Berardi F,Perrone Rdoi
10.2174/156802608785161385subject
Has Abstractpub_date
2008-01-01 00:00:00pages
1024-34issue
12eissn
1568-0266issn
1873-4294journal_volume
8pub_type
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