Abstract:
:Neural activity utilizes energy resources and requires replenishment of metabolites through vascular dilation. During wake, cortical neurons usually have depolarized membrane potentials and exhibit frequent spontaneous action potentials, requiring an increased metabolic delivery to activated tissue and causing blood vessels to dilate. Quiet sleep (QS) is characterized by alternating membrane potential between a depolarized and hyperpolarized state. The hyperpolarized state has a lower membrane potential and exhibits few action potentials, which may be less metabolically demanding. In order to investigate the relationship between evoked neural and metabolic responses across wake and sleep states, we combined electrical and optical imaging techniques. We implanted rats with screw electrodes to measure evoked response potentials (ERPs), and used a light emitting diode (LED) and photodiode to measure evoked changes in local hemodynamics based on hemoglobin absorption properties. During QS, hemodynamic changes were larger in amplitude compared to wake and rapid eye movement (REM) sleep. In this review, we explore the potential mechanisms for the larger hemodynamic changes. Wake periods may correspond to decreased vessel compliance as they expand to supply tissue with metabolites while sleep periods may decrease metabolic demand and allow vessels to relax and restore compliance.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Schei JL,Rector DMdoi
10.2174/156802611797470349subject
Has Abstractpub_date
2011-01-01 00:00:00pages
2447-51issue
19eissn
1568-0266issn
1873-4294pii
BSP/CTMC/E-Pub/-000188-11-21journal_volume
11pub_type
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章
doi:10.2174/156802607782341055
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journal_title:Current topics in medicinal chemistry
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doi:10.2174/1568026614666140523121427
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journal_title:Current topics in medicinal chemistry
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journal_title:Current topics in medicinal chemistry
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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journal_title:Current topics in medicinal chemistry
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2009-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
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journal_title:Current topics in medicinal chemistry
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
doi:10.2174/156802611796235143
更新日期:2011-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
doi:10.2174/1568026613666131204105652
更新日期:2014-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
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更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Biofilm is a critical virulence factor associated with the strains of Candida spp. pathogens as it confers significant resistance to the pathogen against antifungal drugs. METHODS:A systematic review of the literature was undertaken by focusing on natural products, which have been reported to inhibit biofil...
journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章
doi:10.2174/1568026619666191025154834
更新日期:2019-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
abstract::Multi-drug resistant bacteria are appearing at an alarming rate and impose significant burdens on healthcare systems worldwide. Cationic peptides have shown great promise as broad spectrum antimicrobial agents with a demonstrated ability to kill resistant bacteria, however, issues such as protease susceptibility and t...
journal_title:Current topics in medicinal chemistry
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更新日期:2010-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
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更新日期:2006-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2008-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
pub_type: 杂志文章,评审
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更新日期:2016-01-01 00:00:00
abstract::One of the major events occurring at biological interfaces is the specific recognition of bioactive ligands by their receptor proteins. The elucidation of interacting partners is an immediate entrance into the discovery of medicinal leads. The method of photoaffinity labeling enables the direct probing of target prote...
journal_title:Current topics in medicinal chemistry
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更新日期:2002-03-01 00:00:00
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journal_title:Current topics in medicinal chemistry
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更新日期:2012-01-01 00:00:00
abstract::Phyllanthus amarus is a medicinal herb used in traditional Indian medicine for liver disorders. Several researches also show that it acts primarily in the liver, but the molecules were unidentified for liver protective activity. This study was to determine whether the lignans isolated from P. amarus attenuates the D-g...
journal_title:Current topics in medicinal chemistry
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更新日期:2014-01-01 00:00:00
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journal_title:Current topics in medicinal chemistry
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更新日期:2006-01-01 00:00:00
abstract::Compared with the increasing and widespread bacterial resistance to clinical medicines and the urgent need for cures of intractable diseases, there is a dramatic decline in the numbers of drugs reaching the market or clinical trials. Accordingly, it has become imperative to discover more rational and efficient strateg...
journal_title:Current topics in medicinal chemistry
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更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Fabaceae are a rich source of protease inhibitors. METHODS:A proteinaceous protease inhibitor of 25 KDa designated as Macrotyloma uniflorum protease inhibitor (MUPI) was isolated from seeds of Macrotyloma uniflorum and purified to homogeneity by ammonium sulphate precipitation, DEAE Sepharose column and C...
journal_title:Current topics in medicinal chemistry
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更新日期:2018-01-01 00:00:00
abstract::The human tuberculosis (TB) is primarily caused by Mycobacterium tuberculosis (Mtb) that inhabits inside and amidst immune cells of the host with adapted physiology to regulate interdependent cellular functions with intact pathogenic potential. The complexity of this disease is attributed to various factors such as th...
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更新日期:2020-12-11 00:00:00
abstract::The serotonin receptor subtype 5 HT(1A) was one of the first serotonin receptor subtypes pharmacologically characterized. Over the last twenty years the 5 HT(1A) receptor has been the object of intense research efforts as witnessed by the 5 HT(1A) acting drugs marketed as anxiolytics. In recent years, several new chem...
journal_title:Current topics in medicinal chemistry
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更新日期:2008-01-01 00:00:00