Abstract：
:One of the major events occurring at biological interfaces is the specific recognition of bioactive ligands by their receptor proteins. The elucidation of interacting partners is an immediate entrance into the discovery of medicinal leads. The method of photoaffinity labeling enables the direct probing of target protein through a covalent bond introduced between a ligand and its specific receptor. Thus, the photoaffinity labeling is applied in two stages of drug discovery and development processes. First, the method is useful for the screening of early leads. If the binding site analysis of target protein is important for defining a particular pharmacophore, the photoaffinity labeling will give the structural information at the contact point of drugs with receptors. Second, emerging new technologies, combinatorial chemistry, recombinant DNA techniques, and high-throughput analysis, are extending the potential of photoaffinity labeling to become a rapid and more sensitive means for the identification of drug-receptor pairs as well as the elucidation of molecular recognition mechanism at drug-receptor interfaces. This review focuses on several recent impacts of photoaffinity labeling as a useful tool for drug discovery and developments.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Hatanaka Y,Sadakane Ydoi
10.2174/1568026023394182keywords:
subject
Has Abstractpub_date
2002-03-01 00:00:00pages
271-88issue
3eissn
1568-0266issn
1873-4294journal_volume
2pub_type
杂志文章,评审abstract：:In recent years the development of small organic molecules modulating protein-protein interactions (P-PIs) has drawn major attention in both academic and industrial research. Despite the appreciable progress being made, targeting such extensive interaction areas with comparatively small, drug-like agents has proven to...
journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
pub_type： 杂志文章,评审
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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更新日期：2007-01-01 00:00:00
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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更新日期：2010-01-01 00:00:00
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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更新日期：2002-07-01 00:00:00
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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abstract：:Research over the years has gradually and sequentially highlighted contributory role of hypothalamic- based kisspeptin-signaling axis as a major positive modulator of the neuroendocrinological reproductive axis in mammals. However, a series of landmark studies provided convincing evidence of role of this signaling in ...
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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journal_title：Current topics in medicinal chemistry
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