Abstract:
:In recent years the development of small organic molecules modulating protein-protein interactions (P-PIs) has drawn major attention in both academic and industrial research. Despite the appreciable progress being made, targeting such extensive interaction areas with comparatively small, drug-like agents has proven to be an ambitious objective. This review highlights the reasons rendering this task highly challenging and provides an overview on the latest developments in rational design approaches for P-PI modulators. The significance, scope and limitations of computational methods in this particular field of research are analyzed. Recent successfully identified and designed P-PI modulators are discussed. Thereby, particular focus is taken on small organic molecules disrupting protein-protein interfaces of protein kinases.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Rechfeld F,Gruber P,Hofmann J,Kirchmair Jdoi
10.2174/156802611795589610subject
Has Abstractpub_date
2011-01-01 00:00:00pages
1305-19issue
11eissn
1568-0266issn
1873-4294pii
BSP/CTMC/E-Pub/-00080-11-11journal_volume
11pub_type
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