Abstract:
:As the first stable tachysterol analogs, 14-epi-19-nortachysterol and its 2-substituted derivatives were synthesized using the Stille coupling reaction between the A-ring precursor (three vinylstannanes) and the CD-ring vinyl trifrate. Among them, the 2-methylidene group was hydrogenated with Wilkinson's catalyst regioselectively to obtain 2α- and 2β-methyl analogs after separation; therefore, five new 14-epi-19- nortachysterols were constructed. All 14-epi-19-nortachysterols showed moderate to strong human vitamin D receptor (hVDR) binding affinity except the 2α-(3-hydroxypropoxy) substituted analog. X-ray cocrystallographic analysis of the [truncated hVDR]-[2-methyl-14-epi-19-nortachysterol] complex exhibited an unusual binding structure that has not been observed previously.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Sawada D,Kittaka Adoi
10.2174/1568026615666141208103741subject
Has Abstractpub_date
2014-01-01 00:00:00pages
2454-9issue
21eissn
1568-0266issn
1873-4294pii
CTMC-EPUB-63856journal_volume
14pub_type
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