Can Untargeted Metabolomics Be Utilized in Drug Discovery/Development?

Abstract:

:Untargeted metabolomics is a promising approach for reducing the significant attrition rate for discovering and developing drugs in the pharmaceutical industry. This review aims to highlight the practical decision-making value of untargeted metabolomics for the advancement of drug candidates in drug discovery/development including potentially identifying and validating novel therapeutic targets, creating alternative screening paradigms, facilitating the selection of specific and translational metabolite biomarkers, identifying metabolite signatures for the drug efficacy mechanism of action, and understanding potential drug-induced toxicity. The review provides an overview of the pharmaceutical process workflow to discover and develop new small molecule drugs followed by the metabolomics process workflow that is involved in conducting metabolomics studies. The pros and cons of the major components of the pharmaceutical and metabolomics workflows are reviewed and discussed. Finally, selected untargeted metabolomics literature examples, from primarily 2010 to 2016, are used to illustrate why, how, and where untargeted metabolomics can be integrated into the drug discovery/preclinical drug development process.

journal_name

Curr Top Med Chem

authors

Caldwell GW,Leo GC

doi

10.2174/1568026617666170707130032

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

2716-2739

issue

24

eissn

1568-0266

issn

1873-4294

pii

CTMC-EPUB-84592

journal_volume

17

pub_type

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