Abstract:
:Fatty acid amide hydrolase (FAAH) and monoglyceride lipase (MGL) are hydrolytic enzymes which degrade the endogenous cannabinoids (endocannabinoids) N-arachidonoylethanolamine (anandamide, AEA) and 2-arachidonoylglycerol (2-AG), respectively. Endocannabinoids are an important class of lipid messenger molecules that are produced on demand in response to elevated intracellular calcium levels. They recognize and activate the cannabinoid CB(1) and CB(2) receptors, the molecular targets for Delta(9)-tetrahydrocannabinol (Delta(9)-THC) in marijuana evoking several beneficial therapeutic effects. However, in vivo the cannabimimetic effects of AEA and 2-AG remain weak owing to their rapid inactivation by FAAH and MGL, respectively. The inactivation of FAAH and MGL by specific enzyme inhibitors increases the levels of AEA and 2-AG, respectively, producing therapeutic effects such as pain relief and depression of anxiety.
journal_name
Curr Top Med Chemjournal_title
Current topics in medicinal chemistryauthors
Minkkilä A,Saario S,Nevalainen Tdoi
10.2174/156802610791164238subject
Has Abstractpub_date
2010-01-01 00:00:00pages
828-58issue
8eissn
1568-0266issn
1873-4294pii
BSP/ CTMC /E-Pub/-0051-10-8journal_volume
10pub_type
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