Morphology and biochemistry of the pork tapeworm, Taenia solium.

Abstract:

:This chapter describes the life cycle, general morphology and ultrastructure of the larval and adult stages of Taenia solium, a parasitic flatworm of humans found in underdeveloped countries. Experimental results describing the role of proteins and glycoproteins in the host-parasite relationship, as well as the various strategies the larval stage has developed to evade the host immune responses are analyzed. Characteristics of the tapeworm attachment site in the hamster intestine and the host inflammatory reaction are reviewed. The general morphology and ultrastructure of the experimental tapeworm is described, with emphasis on muscle fiber distribution, the abundance of cytoplasmic glycogen and its association with gap junctions, the development of testis, structure of mature spermatids and vas efferens. Recent descriptions of T. solium actin, myosin and calreticulin components, metabolic steroid pathways, apoptosis and glucose uptake of tapeworms in the hamster model are reviewed.

journal_name

Curr Top Med Chem

authors

Willms K

doi

10.2174/156802608783790875

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

375-82

issue

5

eissn

1568-0266

issn

1873-4294

journal_volume

8

pub_type

杂志文章,评审
  • The critical distance for the cycloaromatization reactions of enediynes.

    abstract::It has been shown that the enediyne anticancer antibiotics e.g., calicheamicin, neocarzinostatin and others cleave DNA via the putative intermediate 1,4-diradical formed in the Bergmann cyclization and are thus useful for cancer chemotherapy. The pharmacological activity of these drugs is based, in general, on the act...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/156802608783955719

    authors: Capitani JF,Gaffney SM,Castaldo L,Mitra A

    更新日期:2008-01-01 00:00:00

  • Innate immunity and vaccines.

    abstract::The use of vaccines has led to tremendous decreases in disease burdens across the world. Many challenges remain in expanding vaccine coverage to new pathogens, however, a struggle further hampered by a lack of understanding into many of the fundamental processes through which vaccines elicit robust immunity. In this r...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/15680266113136660185

    authors: Platt A,Wetzler L

    更新日期:2013-01-01 00:00:00

  • Genetic variability of matrix metalloproteinase genes in cardiovascular disease.

    abstract::It is well established that matrix metalloproteinases (MMPs) contribute to the degradation of the extracellular matrix of coronary plaque and contribute to the thinning of the fibrous cap. As a result, the atheromatous plaque becomes unstable and prone to rupture with consequent clinical manifestations including acute...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026611208011206

    authors: Papageorgiou N,Tousoulis D,Hatzis G,Briasoulis A,Androulakis E,Giolis A,Siasos G,Latsios G,Vogiatzi G,Tentolouris C,Stefanadis C

    更新日期:2012-01-01 00:00:00

  • Inhibition of Pyruvate Dehydrogenase Kinase as a Therapeutic Strategy against Cancer.

    abstract::Cancer cells alter their metabolism to support the uninterrupted supply of biosynthetic molecules required for continuous proliferation. Glucose metabolism is frequently reprogrammed in several tumors in addition to fatty acid, amino acid and glutamine metabolism. Pyruvate Dehydrogenase Kinase (PDK) is a gatekeeper en...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026618666180523105756

    authors: Sradhanjali S,Reddy MM

    更新日期:2018-01-01 00:00:00

  • Therapeutic potential of nitrate esters of commonly used drugs.

    abstract::Organic nitrates, such as nitroglycerin, have been used in clinical practice for more than one century for the treatment of angina, even before the identification of Nitric Oxide (NO) as the so-called Endothelium Derived Relaxing Factor (EDRF). Recently, multiple functions of this molecule in biology and pathophysiolo...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026054679335

    authors: Bolla M,Almirante N,Benedini F

    更新日期:2005-01-01 00:00:00

  • Tyrosinase enzyme: 1. An overview on a pharmacological target.

    abstract::The tyrosinase enzyme (EC 1.14.18.1) is an oxidoreductase inside the general enzyme classification and is involved in the oxidation and reduction process in the epidermis. These chemical reactions that the enzyme catalyzes are of principal importance in the melanogenesis process. This process of melanogenesis is relat...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026614666140523121427

    authors: Casanola-Martin GM,Le-Thi-Thu H,Marrero-Ponce Y,Castillo-Garit JA,Torrens F,Rescigno A,Abad C,Khan MT

    更新日期:2014-01-01 00:00:00

  • Elucidating Treatment of Alzheimer's Disease via Different Receptors.

    abstract::Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. Presently, it is the most common reason for the memory loss and dementia in older individuals. It is patho-physiologically described by extracellular amyloid beta (Aβ) deposition, intracellular n...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026617666170103163715

    authors: Ul Islam B,Khan MS,Jabir NR,Kamal MA,Tabrez S

    更新日期:2017-01-01 00:00:00

  • Surface chemistry influences implant biocompatibility.

    abstract::Implantable medical devices are increasingly important in the practice of modern medicine. Unfortunately, almost all medical devices suffer to a different extent from adverse reactions, including inflammation, fibrosis, thrombosis and infection. To improve the safety and function of many types of medical implants, a m...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802608783790901

    authors: Thevenot P,Hu W,Tang L

    更新日期:2008-01-01 00:00:00

  • Strategies for the discovery and advancement of novel cationic antimicrobial peptides.

    abstract::Multi-drug resistant bacteria are appearing at an alarming rate and impose significant burdens on healthcare systems worldwide. Cationic peptides have shown great promise as broad spectrum antimicrobial agents with a demonstrated ability to kill resistant bacteria, however, issues such as protease susceptibility and t...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802610793176648

    authors: Hadley EB,Hancock RE

    更新日期:2010-01-01 00:00:00

  • Membrane-active Antimicrobial Peptides as Template Structures for Novel Antibiotic Agents.

    abstract::The increase of pathogens being resistant to antibiotics represents a global health problem and therefore it is a pressing need to develop antibiotics with novel mechanisms of action. Host defense peptides, which have direct antimicrobial activity (also termed antimicrobial peptides) or immune modulating activity, are...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:

    authors: Lohner K

    更新日期:2017-01-01 00:00:00

  • Molecular biology of nucleoside transporters and their distributions and functions in the brain.

    abstract::Pyrimidine and purine nucleosides and their derivatives have critical functions and pharmacological applications in the brain. Nucleosides and nucleobases are precursors of nucleotides, which serve as the energy-rich currency of intermediary metabolism and as precursors of nucleic acids. Nucleosides (e.g., adenosine) ...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802611795347582

    authors: Parkinson FE,Damaraju VL,Graham K,Yao SY,Baldwin SA,Cass CE,Young JD

    更新日期:2011-01-01 00:00:00

  • Antioxidative Effects of Rhodiola Genus: Phytochemistry and Pharmacological Mechanisms against the Diseases.

    abstract::Rhodiola as one of traditional medicines has been used for clinical treatments due to its strong antioxidant properties. Phytochemical analysis revealed the presence of flavonoids, phenylpropanoids, phenylethanol/benzyl alcohol derivatives, cyanogenic glycosides and terpenoids. The bioactive compounds had been demonst...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026617666161116141334

    authors: Li Y,Wu J,Shi R,Li N,Xu Z,Sun M

    更新日期:2017-01-01 00:00:00

  • Transient receptor potential (TRP) channels and cardiac fibrosis.

    abstract::Cardiac fibrosis is associated with most cardiac diseases. Fibrosis is an accumulation of excessive extracellular matrix proteins (ECM) synthesized by cardiac fibroblasts and myofibroblasts. Fibroblasts are the most prevalent cell type in the heart, comprising 75% of cardiac cells. Myofibroblasts are hardly present in...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026611313030005

    authors: Yue Z,Zhang Y,Xie J,Jiang J,Yue L

    更新日期:2013-01-01 00:00:00

  • Progress in the development of selective inhibitors of aurora kinases.

    abstract::Errors in the mitotic process are thought to be one of the principal sources of the genetic instability that hallmarks cancer. Unsurprisingly, many of the proteins that regulate mitosis are aberrantly expressed in tumour cells when compared to their normal counterparts. These may represent a good source of targets for...

    journal_title:Current topics in medicinal chemistry

    pub_type: 更正并重新发布的文章,杂志文章,评审

    doi:10.2174/1568026054637719

    authors: Mortlock AA,Keen NJ,Jung FH,Heron NM,Foote KM,Wilkinson RW,Green S

    更新日期:2005-01-01 00:00:00

  • The medicinal chemistry of agents targeting monoacylglycerol lipase.

    abstract::Monoacylglycerol lipase (MAGL) has been recently proposed as the main enzymatic activity responsible for the in vivo hydrolysis of the most abundant endocannabinoid in the brain, the 2-arachidonoylglycerol (2-AG). The endocannabinoids, mainly anandamide (AEA) and 2-AG, are a class of lipid messengers that modulate a b...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802608783498032

    authors: Viso A,Cisneros JA,Ortega-Gutiérrez S

    更新日期:2008-01-01 00:00:00

  • World Chagas Disease Day and the New Road Map for Neglected Tropical Diseases.

    abstract::The first-ever World Chagas Disease Day, celebrated in April 14, 2020, is a key initiative to raise awareness of the impact of this neglected tropical disease (NTD). This landmark comes along with the first World NTD Day and the new WHO Road Map on NTDs for 2021-2030. ...

    journal_title:Current topics in medicinal chemistry

    pub_type: 社论

    doi:10.2174/156802662017200624115305

    authors: Ferreira LLG,Andricopulo AD

    更新日期:2020-01-01 00:00:00

  • CORAL: classification model for predictions of anti-sarcoma activity.

    abstract::A modified version of the CORAL software (http://www.insilico.eu/coral) allows building up the classification model for the case of the Yes/No data on the anti-sarcoma activity of organic compounds. Three random splits into the sub-training, calibration, and test sets of the data for 3017 compounds were examined. The ...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1568026611212240004

    authors: Toropov AA,Toropova AP,Benfenati E,Gini G,Leszczynska D,Leszczynski J

    更新日期:2012-01-01 00:00:00

  • Ethnobotany and natural products: the search for new molecules, new treatments of old diseases or a better understanding of indigenous cultures?

    abstract::Results of various projects on Mexican Indian ethnobotany and some of the subsequent pharmacological and phytochemical studies are summarised focusing both on chemical-pharmacological as well as anthropological (ethnopharmacological) aspects of our research. We have identified taste and smell properties of medicinal (...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026033392570

    authors: Heinrich M

    更新日期:2003-01-01 00:00:00

  • Molecules and Metabolites from Natural Products as Inhibitors of Biofilm in Candida spp. pathogens.

    abstract:BACKGROUND:Biofilm is a critical virulence factor associated with the strains of Candida spp. pathogens as it confers significant resistance to the pathogen against antifungal drugs. METHODS:A systematic review of the literature was undertaken by focusing on natural products, which have been reported to inhibit biofil...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1568026619666191025154834

    authors: Singla RK,Dubey AK

    更新日期:2019-01-01 00:00:00

  • Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives.

    abstract::Chagas disease and African sleeping sickness are trypanosomal infections that represent important public health problems in Latin America and Africa, respectively. The restriction of these diseases to the poorer parts of the world has meant that they have been largely neglected and limited progress has been made in th...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802611796575894

    authors: Wilkinson SR,Bot C,Kelly JM,Hall BS

    更新日期:2011-01-01 00:00:00

  • Immunotherapeutic and immunoregulatory drugs in haematologic malignancies.

    abstract::A better understanding of the biology and pathogenesis of hematological malignancies has led to the development of immunotherapeutic and immunoregulatory drugs. Many of these agents have revolutionized the current treatment modalities, while others are under investigation. Rituximab (anti-CD20 antibody) has been estab...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802606778194235

    authors: Pangalis GA,Kyrtsonis MC,Vassilakopoulos TP,Dimopoulou MN,Siakantaris MP,Emmanouilides C,Doufexis D,Sahanas S,Kontopidou FN,Kalpadakis C,Angelopoulou MK,Dimitriadou EM,Kokoris SI,Panayiotidis P

    更新日期:2006-01-01 00:00:00

  • Metal-based antioxidants--potential therapeutic candidates for prevention the oxidative stress-related carcinogenesis: mini-review.

    abstract::The oxidative stress that is associated with the abnormal level of reactive oxygen species (ROS) is considered to be involved in the carcinogenesis process. The antioxidative defense system in the living organism regulates the toxic impact of ROS and there is strong evidence that the antioxidants prevent carcinogenesi...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802611798040741

    authors: Milaeva ER

    更新日期:2011-01-01 00:00:00

  • Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking.

    abstract::The connection of microbial biosynthetic gene clusters to the small molecule metabolites they encode is central to the discovery and characterization of new metabolic pathways with ecological and pharmacological potential. With increasing microbial genome sequence information being deposited into publicly available da...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026616666151012111046

    authors: Trautman EP,Crawford JM

    更新日期:2016-01-01 00:00:00

  • Pyranose N-glycosyl amines: emerging targets with diverse biological potential.

    abstract::Interest in the chemistry and biological properties of non-nucleoside N-glycosidic compounds has gathered pace over the past several years; the occurrence of the N-glycoside moiety in glycoproteins and a range of active natural products has prompted the synthesis of a diverse spectrum of related materials with promisi...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/156802608783378837

    authors: Norris P

    更新日期:2008-01-01 00:00:00

  • Repurposed drugs for the treatment of schizophrenia and bipolar disorders.

    abstract::Characteristic symptoms of schizophrenia and bipolar disorders have been described and classified about a century ago. Each of these disorders may cause considerable impairment reflecting substantial alterations in cognition, perception, and mood. Though both disease concepts are well established, psychopharmacologica...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/15680266113136660165

    authors: Bumb JM,Enning F,Leweke FM

    更新日期:2013-01-01 00:00:00

  • Nanoparticles vs cancer: a multifuncional tool.

    abstract::Nanotechnology is revolutionizing the development of different branches of science. The investigation of nanomaterials in the battle against cancer is not an exception. The main goal of this contribution is to bring an overview about the types of organic and inorganic nanomaterials that are under investigation for its...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026614666140118213316

    authors: Sanchez-Dominguez CN,Gallardo-Blanco HL,Rodriguez-Rodriguez AA,Vela-Gonzalez AV,Sanchez-Dominguez M

    更新日期:2014-03-01 00:00:00

  • Cyclic Peptides that Govern Signal Transduction Pathways: From Prokaryotes to Multi-Cellular Organisms.

    abstract::Cyclic peptide scaffolds are key components of signal transduction pathways in both prokaryotic and eukaryotic organisms since they act as chemical messengers that activate or inhibit specific cognate receptors. In prokaryotic organisms these peptides are utilized in non-essential pathways, such as quorum sensing, tha...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026618666180518090705

    authors: Mull RW,Harrington A,Sanchez LA,Tal-Gan Y

    更新日期:2018-01-01 00:00:00

  • Lanreotide and its Potential Applications in Polycystic Kidney and Liver Diseases.

    abstract::Multiple Gαi protein-coupled somatostatin receptors (SSTRs) are expressed in human kidney and liver tissues. Also, aberrant cAMP signaling has been shown to play a critical role in cysto-genesis and enlargement of the human kidney and liver. Thus, somatostatin (SST) analogs become potential and promising alternatives ...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章,评审

    doi:10.2174/1568026615666150701115157

    authors: Sun L,Yu CY,Mackey LV,Coy DH

    更新日期:2015-01-01 00:00:00

  • Current Breakthroughs in Structure-based Design of Synthetic and Natural Sourced Inhibitors Against Zika Viral Targets.

    abstract:BACKGROUND:Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly a...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/1568026619666181120125525

    authors: Nandi S,Kaur R,Kumar M,Sharma A,Naaz A,Mandal SC

    更新日期:2018-01-01 00:00:00

  • Dipeptide inhibitors of thermolysin and angiotensin I-converting enzyme.

    abstract::Thermolysin (TLN) and other thermolysin-like zinc metalloproteinases (TLPs),are important virulence factors for pathogenesis of bacterial infections by suppressing the innate immune system of the host. Therapeutic inhibition ofTLPs is believed to be a novel strategy inthe development of a new generation antibiotics.In...

    journal_title:Current topics in medicinal chemistry

    pub_type: 杂志文章

    doi:10.2174/156802612803989246

    authors: Khan MT,Dedachi K,Matsui T,Kurita N,Borgatti M,Gambari R,Sylte I

    更新日期:2012-01-01 00:00:00