Activated Leukocyte Cell Adhesion Molecule Stimulates the T-Cell Response in Allergic Asthma.

abstract：:In mechanically ventilated neonates, the instrumental dead space is a major determinant of total minute ventilation. By flushing this dead space, continuous tracheal gas insufflation (CTGI) may allow reduction of the risk of overinflation. We conducted a randomized trial to evaluate the efficacy of CTGI in reducing ai...

journal_title：American journal of respiratory and critical care medicine

authors： Dassieu G,Brochard L,Benani M,Avenel S,Danan C

更新日期：2000-09-01 00:00:00

abstract：RATIONALE:Peroxisome proliferator-activated receptor (PPAR)-β/δ is a transcription factor that belongs to the PPAR nuclear hormone receptor family, but the role of PPAR-β/δ in sepsis is unknown. OBJECTIVES:We investigated the role of PPAR-β/δ in murine models of LPS-induced organ injury and dysfunction and cecal ligat...

journal_title：American journal of respiratory and critical care medicine

authors： Kapoor A,Shintani Y,Collino M,Osuchowski MF,Busch D,Patel NS,Sepodes B,Castiglia S,Fantozzi R,Bishop-Bailey D,Mota-Filipe H,Yaqoob MM,Suzuki K,Bahrami S,Desvergne B,Mitchell JA,Thiemermann C

更新日期：2010-12-15 00:00:00

abstract：:REM-related oxygen desaturation occurs in advanced Duchenne muscular dystrophy (DMD) and might be an independent predictor of disease progression. We have followed 18 patients for 10 yr after an initial respiratory sleep study or until death or onset of nasal ventilation. We measured baseline spirometry, blood gas ten...

journal_title：American journal of respiratory and critical care medicine

authors： Phillips MF,Smith PE,Carroll N,Edwards RH,Calverley PM

更新日期：1999-07-01 00:00:00

abstract：RATIONALE:Most patients with pulmonary arterial hypertension (PAH) die from right heart failure. Beta-adrenergic receptor blockade reduces mortality by about 30% in patients with left-sided systolic heart failure, but is not used in PAH. OBJECTIVES:To assess the effect of the adrenergic receptor blocker carvedilol on ...

journal_title：American journal of respiratory and critical care medicine

authors： Bogaard HJ,Natarajan R,Mizuno S,Abbate A,Chang PJ,Chau VQ,Hoke NN,Kraskauskas D,Kasper M,Salloum FN,Voelkel NF

更新日期：2010-09-01 00:00:00

abstract：:To determine the incidence and 90-d mortality of acute respiratory failure (ARF), acute lung injury (ALI), and the acute respiratory distress syndrome (ARDS), we carried out an 8-wk prospective cohort study in Sweden, Denmark, and Iceland. All intensive care unit (ICU) admissions (n = 13,346) >/= 15 yr of age were ass...

journal_title：American journal of respiratory and critical care medicine

authors： Luhr OR,Antonsen K,Karlsson M,Aardal S,Thorsteinsson A,Frostell CG,Bonde J

更新日期：1999-06-01 00:00:00

abstract：RATIONALE:Very little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles. OBJECTIVES:To examine the structure of preterminal bronchioles located one generation proximal to terminal bronchioles in centrilobular and panlobular em...

journal_title：American journal of respiratory and critical care medicine

authors： Tanabe N,Vasilescu DM,McDonough JE,Kinose D,Suzuki M,Cooper JD,Paré PD,Hogg JC

更新日期：2017-03-01 00:00:00

abstract：:A variety of substances including human meconium have been found to affect adversely the surface tension-lowering activity of pulmonary surfactants, and this effect may be important in the pathogenesis of a number of human diseases. To find whether inactivation of surfactant could be prevented or reduced by nonionic p...

journal_title：American journal of respiratory and critical care medicine

authors： William Taeusch H,Lu KW,Goerke J,Clements JA

更新日期：1999-05-01 00:00:00

abstract：:The respiratory-related evoked potential (RREP) is the electroencephalographic response to brief inspiratory occlusion. The P3 component of the response reflects the active cognitive processing of stimulus information. This study investigated the RREP in 16 subjects with asthma and 16 control subjects. In addition, au...

journal_title：American journal of respiratory and critical care medicine

authors： Webster KE,Colrain IM

更新日期：2002-07-01 00:00:00

abstract：RATIONALE:Transthoracic Doppler echocardiography is recommended for screening for the presence of pulmonary hypertension (PH). However, some recent studies have suggested that Doppler echocardiographic pulmonary artery pressure estimates may frequently be inaccurate. OBJECTIVES:Evaluate the accuracy of Doppler echocar...

journal_title：American journal of respiratory and critical care medicine

authors： Fisher MR,Forfia PR,Chamera E,Housten-Harris T,Champion HC,Girgis RE,Corretti MC,Hassoun PM

更新日期：2009-04-01 00:00:00

abstract：RATIONALE:Severe sepsis and septic shock are leading causes of intensive care unit (ICU) admission, morbidity, and mortality. The effect of compliance with sepsis management guidelines on outcomes is unclear. OBJECTIVES:To assess the effect on mortality of compliance with a severe sepsis and septic shock management bu...

journal_title：American journal of respiratory and critical care medicine

authors： Miller RR 3rd,Dong L,Nelson NC,Brown SM,Kuttler KG,Probst DR,Allen TL,Clemmer TP,Intermountain Healthcare Intensive Medicine Clinical Program.

更新日期：2013-07-01 00:00:00

abstract：:The expression of renin-angiotensin system components and the elevation of angiotensin-converting enzyme (ACE) in a number of fibrotic lung diseases suggests angiotensin II (AII) could play a role in the pathogenesis of pulmonary fibrosis. However, the effect of AII on lung fibroblasts has not previously been assessed...

journal_title：American journal of respiratory and critical care medicine

authors： Marshall RP,McAnulty RJ,Laurent GJ

更新日期：2000-06-01 00:00:00

abstract：RATIONALE:Venous thromboembolism is difficult to diagnose in critically ill patients and may increase morbidity and mortality. OBJECTIVES:To evaluate the cost-effectiveness of strategies to reduce morbidity from venous thromboembolism in critically ill patients. METHODS:A Markov decision analytic model to compare wee...

journal_title：American journal of respiratory and critical care medicine

authors： Sud S,Mittmann N,Cook DJ,Geerts W,Chan B,Dodek P,Gould MK,Guyatt G,Arabi Y,Fowler RA,Canadian Critical Care Trials Group.,E-PROTECT Investigators.

更新日期：2011-12-01 00:00:00

abstract：:Clinicians are frequently faced with patients in whom the radiographic resolution of community-acquired pneumonia seems delayed. Previous studies of radiographic resolution of the disease have yielded conflicting results. We prospectively assessed the radiographic resolution of pneumonia in 81 non-immuno-compromised p...

journal_title：American journal of respiratory and critical care medicine

authors： Mittl RL Jr,Schwab RJ,Duchin JS,Goin JE,Albeida SM,Miller WT

更新日期：1994-03-01 00:00:00

abstract：:Lipoteichoic acids (LTA) and peptidoglycans (PepG) are major components of the cell walls of gram-positive bacteria that trigger inflammatory responses in vitro. To study the in vivo effects of LTA and PepG from Staphylococcus aureus in lungs and to determine the role of interleukin (IL)-6 herein, these compounds were...

journal_title：American journal of respiratory and critical care medicine

authors： Leemans JC,Vervoordeldonk MJ,Florquin S,van Kessel KP,van der Poll T

更新日期：2002-05-15 00:00:00

abstract：:The number of patients awaiting lung transplantation (LT) and waiting time for surgery is increasing. In Australia, LT rates are 4. 6/million population/yr, which despite low organ donation rates, are the highest published in the world. The Australian organ allocation system allows identification of marginal donors an...

journal_title：American journal of respiratory and critical care medicine

authors： Gabbay E,Williams TJ,Griffiths AP,Macfarlane LM,Kotsimbos TC,Esmore DS,Snell GI

更新日期：1999-07-01 00:00:00

abstract：:The virulence of Pseudomonas aeruginosa is partly controlled by the las quorum-sensing system. A rat model of acute pneumonia was used to investigate the pathophysiological impact of this system by comparing the virulence of the wild-type virulent laboratory strain PAO1 with that of its lasR-deleted mutant PAOR. In co...

journal_title：American journal of respiratory and critical care medicine

authors： Lesprit P,Faurisson F,Join-Lambert O,Roudot-Thoraval F,Foglino M,Vissuzaine C,Carbon C

更新日期：2003-06-01 00:00:00

abstract：:Numerous in vitro and in vivo studies in both animals and patients with asthma have shown that interleukin (IL)-9 is an important inflammatory mediator in asthma. To examine the effects of IL-9 antagonism on airway inflammation, ovalbumin-sensitized BALB/c mice were intravenously given anti-IL-9 antibody or an isotype...

journal_title：American journal of respiratory and critical care medicine

authors： Cheng G,Arima M,Honda K,Hirata H,Eda F,Yoshida N,Fukushima F,Ishii Y,Fukuda T

更新日期：2002-08-01 00:00:00

abstract：:Dysfunction of the muscles of ambulation contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). Men with COPD have high prevalence of low testosterone levels, which may contribute to muscle weakness. We determined effects of testosterone supplementation (100 mg of testosterone enanthate i...

journal_title：American journal of respiratory and critical care medicine

authors： Casaburi R,Bhasin S,Cosentino L,Porszasz J,Somfay A,Lewis MI,Fournier M,Storer TW

更新日期：2004-10-15 00:00:00

abstract：:The effects of conventional mechanical ventilation (CMV) and high-frequency oscillatory ventilation (HFO) on intraalveolar expression of the tumor necrosis factor-alpha (TNF-alpha) gene were studied in surfactant-depleted rabbits. After lung lavage with saline, 13 rabbits were administered either CMV (n = 6) or HFO (n...

journal_title：American journal of respiratory and critical care medicine

authors： Takata M,Abe J,Tanaka H,Kitano Y,Doi S,Kohsaka T,Miyasaka K

更新日期：1997-07-01 00:00:00

abstract：RATIONALE:The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF. OBJECTIVES:To understand the gene expression patterns of acute exacerbations of IPF. METHODS:RNA was extracted ...

journal_title：American journal of respiratory and critical care medicine

authors： Konishi K,Gibson KF,Lindell KO,Richards TJ,Zhang Y,Dhir R,Bisceglia M,Gilbert S,Yousem SA,Song JW,Kim DS,Kaminski N

更新日期：2009-07-15 00:00:00

abstract：RATIONALE:Activins are members of the transforming growth factor-beta superfamily thought to be involved in repair processes after tissue injury. OBJECTIVES:The aim of this study was to clarify whether activin and its antagonist, follistatin, played a significant role in lung injury and fibrosis. METHODS AND RESULTS:...

journal_title：American journal of respiratory and critical care medicine

authors： Aoki F,Kurabayashi M,Hasegawa Y,Kojima I

更新日期：2005-09-15 00:00:00

abstract：:Although considerable evidence indicates a role for CD4(+) T lymphocytes (T cells) in airway inflammation, little data exist regarding the mechanisms underlying the induction and regulation of CD4(+) T cell reactivity to lung-specific antigens. To dissect the immunologic and molecular mechanisms of CD4(+) T cell dysre...

journal_title：American journal of respiratory and critical care medicine

authors： Bruder D,Westendorf AM,Geffers R,Gruber AD,Gereke M,Enelow RI,Buer J

更新日期：2004-12-01 00:00:00

abstract：:The inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha) and interleukin-1-beta (IL-1 beta), have been associated with accelerated metabolism and protein turnover following exogenous administration in normal humans. We hypothesized that these inflammatory cytokines might contribute to the weight-losing proc...

journal_title：American journal of respiratory and critical care medicine

authors： de Godoy I,Donahoe M,Calhoun WJ,Mancino J,Rogers RM

更新日期：1996-02-01 00:00:00

abstract：:The reaction of nitric oxide (NO) and superoxide anions (O(2)(-)) in the airway results in the formation of peroxynitrite, a highly reactive oxidant species. Peroxynitrite reacts with tyrosine residues in proteins to form the stable product nitrotyrosine. We investigated whether nitrotyrosine in exhaled breath condens...

journal_title：American journal of respiratory and critical care medicine

authors： Hanazawa T,Kharitonov SA,Barnes PJ

更新日期：2000-10-01 00:00:00

abstract：:The role of nutritional status in the prognosis of subjects with severe chronic obstructive pulmonary disease was studied in a cohort of Canadian men and women followed for 3 to 5 yr. A total of 348 subjects who were recruited for a study of negative pressure ventilation were evaluated for lung function and body weigh...

journal_title：American journal of respiratory and critical care medicine

authors： Gray-Donald K,Gibbons L,Shapiro SH,Macklem PT,Martin JG

更新日期：1996-03-01 00:00:00

abstract：:To investigate the mechanisms underlying ventilator-dependence in patients with chronic obstructive pulmonary disease (COPD), and to assess the effects of the combination of positive end-expiratory pressure (PEEP) and pressure-support ventilation (PSV) on inspiratory muscle effort, we investigated respiratory mechanic...

journal_title：American journal of respiratory and critical care medicine

authors： Appendini L,Purro A,Patessio A,Zanaboni S,Carone M,Spada E,Donner CF,Rossi A

更新日期：1996-11-01 00:00:00

abstract：RATIONALE:HIV-tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is an immunopathological reaction to mycobacterial antigens induced by antiretroviral therapy. Prednisone reduces morbidity in TB-IRIS, but the mechanisms are unclear. OBJECTIVES:To determine the effect of prednisone on the inf...

journal_title：American journal of respiratory and critical care medicine

authors： Meintjes G,Skolimowska KH,Wilkinson KA,Matthews K,Tadokera R,Conesa-Botella A,Seldon R,Rangaka MX,Rebe K,Pepper DJ,Morroni C,Colebunders R,Maartens G,Wilkinson RJ

更新日期：2012-08-15 00:00:00

abstract：:To gain insight into the source of exhaled nitric oxide (NO) in normal humans, we examined the effects of respiratory pattern on the concentration of NO in exhaled air while subjects were wearing a noseclip and then under endotracheal intubation, using a specially designed gas sampling system to separate exhaled air i...

journal_title：American journal of respiratory and critical care medicine

authors： Tsujino I,Miyamoto K,Nishimura M,Shinano H,Makita H,Saito S,Nakano T,Kawakami Y

更新日期：1996-11-01 00:00:00

abstract：:E-selectin, an early mediator of leukocyte-endothelial adhesion, is expressed on activated endothelium. Soluble E-selectin is present in the supernatant of cytokine-activated endothelial cells and elevated serum levels are found in a variety of inflammatory conditions. We documented elevated E-selectin serum levels in...

journal_title：American journal of respiratory and critical care medicine

authors： Cummings CJ,Sessler CN,Beall LD,Fisher BJ,Best AM,Fowler AA 3rd

更新日期：1997-08-01 00:00:00

abstract：:The cost effectiveness of asthma care is the first topic of the National Asthma Education and Prevention Program Task Force Report on the Cost Effectiveness, Quality of Care, and Financing of Asthma Care. This working group characterized the role of health economics in understanding optimal asthma management strategie...

journal_title：American journal of respiratory and critical care medicine

authors： Sullivan S,Elixhauser A,Buist AS,Luce BR,Eisenberg J,Weiss KB

更新日期：1996-09-01 00:00:00