Abstract：
:The subtle mechanisms by which protein-DNA interactions remain functional across a wide range of temperatures are largely unknown. In this work, we manually curated available information relating fully sequenced archaeal genomes with organism growth temperatures. We built a motif that represents the core promoter of each species and calculated its information content. We then studied the relation between optimal growth temperature (OGT) and information content (IC) in the promoter region.We found a positive correlation between G + C content and OGT in tRNA regions and not in overall genome. Furthermore, we found that there is a positive correlation between information content and optimal growth temperatures in Archaea. This can't be explained by an increased C+G composition nor by other obvious mechanisms. These findings suggest that increased information content could produce a positive fitness in organisms living at high temperatures. We suggest that molecular information theory may need to be adapted for hyperthermophiles.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Aptekmann AA,Nadra ADdoi
10.1038/s41598-018-19495-8subject
Has Abstractpub_date
2018-01-22 00:00:00pages
1313issue
1issn
2045-2322pii
10.1038/s41598-018-19495-8journal_volume
8pub_type
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journal_title：Scientific reports
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pub_type： 杂志文章,已发布勘误
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pub_type： 杂志文章,meta分析,评审
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