Abstract:
:Background Addictive-like behaviors (e.g., hoarding and shopping) may be the result of the cumulative effects of dopaminergic and other neurotransmitter genetic variants as well as elevated stress levels. We, therefore, propose that dopamine homeostasis may be the preferred goal in combating such challenging and unwanted behaviors, when simple dopaminergic activation through potent agonists may not provide any resolution. Case presentation C.J. is a 38-year-old, single, female, living with her mother. She has a history of substance use disorder as well as attention deficit hyperactivity disorder, inattentive type. She had been stable on buprenorphine/naloxone combination and amphetamine, dextroamphetamine mixed salts for many years when unexpectedly she lost her job for oversleeping and not calling into work. KB200z (a pro-dopamine compound) was added to her regimen for complaints of low drive and motivation. After taking this nutraceutical for 4 weeks, she noticed a marked improvement in her mental status and many behaviors. She noted that her shopping and hoarding addictions had appreciably decreased. Furthermore, her lifelong history of terrifying lucid dreams was eliminated. Finally, she felt more in control; her locus of control shifted from external to more internal. Discussion The hypothesis is that C.J.'s reported, behavioral, and psychological benefits resulted from the pro-dopamine-regulating effect of KB220Z across the brain reward system. Conclusions This effect, we surmise, could be the result of a new dopamine balance, across C.J.'s brain reward system. Dopamine homeostasis is an effect of KB220Z seen in both animal and human placebo-controlled fMRI experiments.
journal_name
J Behav Addictjournal_title
Journal of behavioral addictionsauthors
McLaughlin T,Blum K,Steinberg B,Modestino EJ,Fried L,Baron D,Siwicki D,Braverman ER,Badgaiyan RDdoi
10.1556/2006.6.2017.081subject
Has Abstractpub_date
2018-03-01 00:00:00pages
192-203issue
1eissn
2062-5871issn
2063-5303journal_volume
7pub_type
杂志文章abstract:BACKGROUND:Decision-making and risk-taking behavior undergo developmental changes during adolescence. Disadvantageous decision-making and increased risk-taking may lead to problematic behaviors such as substance use and abuse, pathological gambling and excessive internet use. METHODS:Based on MEDLINE searches, this ar...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/JBA.2.2013.1.1
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Past research suggests that sleep problems are associated with increased risky decision-making. Similarly, gambling disorder and alcohol use disorder are also associated with increased risky decision-making. Individuals with gambling disorder or alcohol use disorder have also reported higher rates o...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/JBA.3.2014.014
更新日期:2014-09-01 00:00:00
abstract::Background and aims People with substance abuse and pathological gamblers show an attentional bias. In a laboratory setting, we found an attentional bias using an addiction Stroop in adults with Internet Gaming Disorder (IGD). We aimed at investigating this effect using two web-based experiments. Methods Study 1: Game...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.5.2016.075
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND AND AIMS:Overindulgence in Internet gaming, which is related to rapid development of the online game industry, can cause a psychiatric disorder known as Internet gaming disorder (IGD). The number of adolescents with IGD is on the rise in countries with developed Internet technologies, such as South Korea. Th...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.8.2019.65
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The "process-model" of self-control proposes that the ego-depletion effect is better explained by a switch between interest in "have-to" labor and cognitive "want-to" leisure, rather than being mainly due to a decrease in cognitive resources, as advanced by the "strength-model" of self-control. Howe...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.7.2018.97
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND AIMS:This systematic review analyzes and summarizes gambling-related findings from the nationally representative US National Epidemiological Survey on Alcohol and Related Conditions (NESARC) data. METHODS:Systematic literature searches in accordance with PRISMA guidelines found 51 eligible studies that ...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.8.2019.64
更新日期:2019-12-01 00:00:00
abstract::Background and aims Problem gambling has been identified as an emergent public health issue, and there is a need to identify gambling trends and to regularly update worldwide gambling prevalence rates. This paper aims to review recent research on adult gambling and problem gambling (since 2000) and then, in the contex...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章,评审
doi:10.1556/2006.5.2016.073
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:The initial treatment of obsessive-compulsive disorder (OCD) has generally been limited to serotonergic agents, cognitive-behavioral therapy (CBT), or a combination of the two. These findings were supported by the POTS study for OCD in children and adolescents. However, treatment with serotonergic agents or ...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/JBA.1.2012.2.6
更新日期:2012-06-01 00:00:00
abstract::Background and aims Personalized feedback interventions (PFI) have shown success as a low-cost, scalable intervention for reducing problematic and excessive consumption of alcohol. Recently, researchers have begun to apply PFI as an intervention method for problematic gambling behaviors. A systematic review of the lit...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章,评审
doi:10.1556/2006.5.2016.006
更新日期:2016-03-01 00:00:00
abstract:Background and Aims:Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.2020.00006
更新日期:2020-04-01 00:00:00
abstract:Background and aims:Interest surrounding the relationship between flow and problematic gameplay has surged. An important antecedent of flow in the context of video-gaming is the skill-challenge balance, but researchers have only manipulated this balance by changing speed of play. The current research seeks to examine t...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.2020.00070
更新日期:2020-10-06 00:00:00
abstract:BACKGROUND AND AIMS:Direct messaging via text messages (texts) and emails is a widely used method to advertise sports and race-betting offers. However, they have attracted little research, as this advertising is not in the public domain. This study aimed to determine whether betting expenditure is related to receiving ...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.7.2018.99
更新日期:2018-12-01 00:00:00
abstract::Backgrounds and aims This study focuses on the role of time perspective (TP) in Internet gaming disorder (IGD). An inventory-based study on 377 massive multiplayer online role playing game players was conducted, followed by a 3-year-follow-up in which 48 active players from the original sample participated. We propose...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.6.2017.089
更新日期:2018-03-01 00:00:00
abstract::The proposed introduction of gaming disorder (GD) in the 11th revision of the International Classification of Diseases (ICD-11) developed by the World Health Organization (WHO) has led to a lively debate over the past year. Besides the broad support for the decision in the academic press, a recent publication by van R...
journal_title:Journal of behavioral addictions
pub_type: 评论,杂志文章
doi:10.1556/2006.7.2018.59
更新日期:2018-09-01 00:00:00
abstract::Background and aims Epidemiological data have suggested that the prevalence of co-occurring personality disorders is particularly high in people with gambling disorder (GD). Among the personality disorders, obsessive-compulsive personality disorder (OCPD) appears to be the most common problem. The objective of this st...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.7.2018.50
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Problematic Internet use and excessive alcohol consumption have been associated with a host of maladaptive outcomes. Further, low (blunted) cardiovascular and stress hormone (e.g. cortisol) reactions to acute psychological stress are a feature of individuals with a range of adverse health and behavi...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.4.2015.006
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Previous research has identified exercise identity and social physique anxiety as two independent factors that are associated with exercise dependence. AIMS:The purpose of our study was to investigate the unique and interactive effect of these two known correlates of exercise dependence in a sample of 1,766...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.4.2015.020
更新日期:2015-09-01 00:00:00
abstract::This commentary intends to provide constructive input into the "Ten myths about work addiction" by Griiffiths et al. (2018). I place the information into an appetitive motivation theoretical lens of addiction as well as outline the kernels of truth associated with each myth. Advancement of an understanding of the unde...
journal_title:Journal of behavioral addictions
pub_type: 评论,杂志文章
doi:10.1556/2006.7.2018.120
更新日期:2018-12-01 00:00:00
abstract::The present paper encompasses a response to the debate paper by Griffiths et al. about work addiction myths. Generally, we found weak empirical basis for the statement that there exist major myths and controversies regarding work addiction. Although we agree with Griffiths et al. on several issues, we argue that: (a) ...
journal_title:Journal of behavioral addictions
pub_type: 评论,杂志文章
doi:10.1556/2006.7.2018.126
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND AND AIMS:To investigate the potential indications and adverse effects of using the opioid antagonist naltrexone to treat problem gamblers. CASE PRESENTATION:The files of the 1,192 patients who were referred to the National Problem Gambling Clinic between January 2015 and June 2016 were audited. Seventeen pa...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.7.2018.89
更新日期:2018-09-01 00:00:00
abstract::Background and aims Although Internet gaming disorder (IGD) has been investigated in detail, minimal research has been conducted regarding the influence of different game genres on IGD. The aim of this study is to compare the characteristics of members of game genre-specific groups with IGD and to identify factors ass...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.6.2017.033
更新日期:2017-06-29 00:00:00
abstract:BACKGROUND AND AIMS:Internet gaming disorder (IGD) was proposed in Diagnostic and Statistical Manual of Mental Disorders of American Psychiatric Association as an area warranting more research attention. High prevalence of excessive Internet game use and related addictions has been reported in China, especially among y...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.8.2019.18
更新日期:2019-06-01 00:00:00
abstract::Background and aims A considerable body of literature has emerged over the past two decades assessing the relationship between problematic or addictive use of the Internet and various indices of psychological well-being. Conversely, comparatively little research has assessed the relationship between problematic or add...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/JBA.1.2012.016
更新日期:2013-06-01 00:00:00
abstract::Background and aims Although first treatment approaches for Internet Use Disorders (IUDs) have proven to be effective, health care utilization remained low. New service models focus on integrated health care systems, which facilitate access and reduce burdens of health care utilization, and stepped-care interventions,...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.6.2017.065
更新日期:2017-12-01 00:00:00
abstract::Background and aims Impulsivity has consistently been associated with over-consumption and addiction. Recent research has reconceptualized impulsivity as a two-dimensional construct ( Dawe, Gullo, & Loxton, 2004 ). This study explores the relationship of the two components of impulsivity, reward drive (RD) and rash im...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.5.2016.047
更新日期:2016-06-01 00:00:00
abstract:PURPOSE:Evidences indicate that Internet addiction disorder (IAD) has a higher risk of developing aggression and violent behavior. A few correlation studies between IAD and aggression have implicated a common biological mechanism. However, neurobiological approaches to IAD and aggression have not yet been studied. MET...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章,评审
doi:10.1556/JBA.3.2014.1.2
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Cue-induced brain reactivity has been suggested to be a fundamental and important mechanism explaining the development, maintenance, and relapse of addiction, including Internet gaming disorder (IGD). Altered activity in addiction-related brain regions has been found during cue-reactivity in IGD using functi...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.8.2019.25
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Many people present excessive patterns of social networking site (SNS) use and try to self-regulate it. However, little is known regarding the strategies employed by young adult SNS users and their role in preventing the emergence of addiction-like symptoms in relation to SNS use. METHODS:In Study ...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.8.2019.49
更新日期:2019-09-01 00:00:00
abstract::Background Behavioral addictions often onset in adolescence and increase the risk of psychological and social problems later in life. The core symptoms of addiction are tolerance, withdrawal symptoms, lack of control, and compulsive occupation with the behavior. Psychometrically validated tools are required for detect...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.7.2018.01
更新日期:2018-03-01 00:00:00
abstract::Background and aims There is a well-established association between pathological gambling and substance use disorders in adolescents. The aim of this study was to shed light on the association between adolescents' different levels of involvement in gambling activities and substance use (smoking tobacco and cannabis an...
journal_title:Journal of behavioral addictions
pub_type: 杂志文章
doi:10.1556/2006.6.2017.043
更新日期:2017-09-01 00:00:00