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Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.

Abstract：

Background and Aims:Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In this meta-analysis, we integrated VBM studies on different BAs to investigate common GM abnormalities in individuals with BAs. Methods:Numerous studies on behavioral addictions (BAs) have reported gray matter (GM) alterations in multiple brain regions by using voxel-based morphometry (VBM). However, findings are poorly replicated and it remains elusive whether distinct addictive behaviors are underpinned by shared abnormalities. In this meta-analysis, we integrated VBM studies on different BAs to investigate common GM abnormalities in individuals with BAs. Results:Twenty studies including 505 individuals with BAs and 564 healthy controls met the inclusion criteria. Compared with healthy controls, individuals with BAs showed GM atrophy in the left anterior cingulate (extending to the left medial superior frontal gyrus and bilateral orbitofrontal gyrus), right putamen and right supplementary motor area. Subgroup analysis found heterogeneity in gender and subtypes of BAs. Meta-regression revealed that GM decreases in the left anterior cingulate and right supplementary motor area were positively correlated with addictive severity. Higher impulsivity was associated with smaller volume of the left anterior cingulate. Discussion and conclusions:Our findings on BAs were mainly derived from internet gaming disorder (IGD) and pathological gambling (PG) studies, preliminarily suggesting that GM atrophy in the prefrontal and striatal areas might be a common structural biomarker of BAs.

journal_name

J Behav Addict

journal_title

Journal of behavioral addictions

authors

Qin K,Zhang F,Chen T,Li L,Li W,Suo X,Lei D,Kemp GJ,Gong Q

doi

10.1556/2006.2020.00006

subject

Has Abstract

pub_date

2020-04-01 00:00:00

pages

1-14

issue

eissn

2062-5871

issn

2063-5303

journal_volume

pub_type

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Shared gray matter alterations in individuals with diverse behavioral addictions: A voxel-wise meta-analysis.