Protective effects of atorvastatin on cerebral vessel autoregulation in an experimental rabbit model of subarachnoid hemorrhage.

abstract：:MicroRNA (miR)-185, which has been reported to be abnormally expressed in some types of cancer, exerts significant effects on the proliferation, apoptosis, drug resistance and metastasis of cancer cells. The present study aimed to explore the effects and underlying molecular mechanisms of miR‑185 upregulation on the a...

journal_title：Molecular medicine reports

authors： Fan L,Tan B,Li Y,Zhao Q,Yuan H,Liu Y,Wang D,Zhang Z

更新日期：2018-02-01 00:00:00

abstract：:Induction of cardiomyocyte proliferation, the most promising approach to reverse myocardial attrition, has been gaining importance as a therapy for cardiovascular disease. Hypoxia and macrophages were previously independently reported to promote cardiomyocyte proliferation in mice. However, whether hypoxia promotes ca...

journal_title：Molecular medicine reports

authors： Liu B,Zhang HG,Zhu Y,Jiang YH,Luo GP,Tang FQ,Jian Z,Xiao YB

更新日期：2017-06-01 00:00:00

abstract：:The present study aimed to determine the role of arginase (Arg) in pulmonary arterial hypertension (PAH). In vitro, human pulmonary artery smooth muscle cells (HPASMCs) were cultured under hypoxic conditions with, or without, the Arg inhibitor, S‑(2‑boronoethyl)‑l‑cysteine (BEC), for 48 h, following which the prolifer...

journal_title：Molecular medicine reports

authors： Jiang W,Sun B,Song X,Zheng Y,Wang L,Wang T,Liu S

更新日期：2015-09-01 00:00:00

abstract：:Atherosclerosis (AS) is a progressive disease of multifactorial origin, which occurs in response to endothelial injury. Increased homocysteine (Hcy) is considered a major cause of endothelial dysfunction, oxidative stress and DNA methylation; however, the mechanisms remain to be fully elucidated. The aim of the presen...

journal_title：Molecular medicine reports

authors： Ma SC,Hao YJ,Jiao Y,Wang YH,Xu LB,Mao CY,Yang XL,Yang AN,Tian J,Zhang MH,Jin SJ,Xu H,Jiang YD,Zhang HP

更新日期：2017-12-01 00:00:00

abstract：:Ovarian hyperstimulation syndrome (OHSS) is a potentially life‑threatening, iatrogenic complication that occurs during assisted reproduction. Polycystic ovarian syndrome (PCOS) significantly increases the risk of OHSS during controlled ovarian stimulation. Therefore, a more effective early prediction technique is requ...

journal_title：Molecular medicine reports

authors： Wu L,Sun Y,Wan J,Luan T,Cheng Q,Tan Y

更新日期：2017-07-01 00:00:00

abstract：:Previous studies have reported that the Rho-associated coiled-coil containing protein kinase 2 (ROCKII) and glycogen synthase kinase‑3β (GSK)‑3β signaling pathways are involved in axonal regeneration. The present study investigated the effects of the combined application of Y27632 (a ROCKII inhibitor) and 4-benzyl-2‑m...

journal_title：Molecular medicine reports

authors： Zhang G,Lei F,Zhou Q,Feng D,Bai Y

更新日期：2016-12-01 00:00:00

abstract：:Acute lung injury (ALI) is a common complication following intestinal ischemia/reperfusion (I/R) and is a major contributing factor to its high mortality rate. Sirtuin 1 (SIRT1), a NAD+-dependent deacetylase, has been reported to have an important role in apoptosis inhibition, oxidative stress resistance and cell life...

journal_title：Molecular medicine reports

authors： Zhang F,Li ZL,Xu XM,Hu Y,Yao JH,Xu W,Jing HR,Wang S,Ning SL,Tian XF

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to investigate the effects of cinobufacini injection on the proliferation and expression of topoisomerases in human HepG-2 hepatocarcinoma cells. The cells were divided into a control group and an experimental group, in which 0.105, 0.21, 0.42 mg/l cinobufacini was injected. Cell proliferation ...

journal_title：Molecular medicine reports

authors： Liu Y,Ban LY,Su X,Gao S,Liu JW,Cui XN

更新日期：2015-07-01 00:00:00

abstract：:Ras‑GTPase‑activating protein SH3 domain‑binding protein 1 (G3BP1) has been reported to be of importance in the occurrence and development of colon cancer. However, the underlying mechanisms remain largely unknown. Therefore, the aim of the present study was to investigate the role of Wnt/β‑catenin signaling in G3BP1‑...

journal_title：Molecular medicine reports

authors： Li Y,Wang J,Zhong S,Li J,Du W

更新日期：2020-11-01 00:00:00

abstract：:The aim of the present study was to determine the role of interleukin-6 (IL-6) in the epithelial-mesenchymal transition (EMT) of human intrahepatic biliary epithelial cell (HIBEC) lines in vitro. HIBECs were stimulated with IL-6 at concentrations of 0, 10, 20, 50 and 100 µg/l for 24 h. A wound healing and Transwell as...

journal_title：Molecular medicine reports

authors： Jiang GX,Cao LP,Kang PC,Zhong XY,Lin TY,Cui YF

更新日期：2016-02-01 00:00:00

abstract：:β-amyloid (Aβ)-mediated neuronal apoptosis is an important pathological feature of Alzheimer's disease (AD). Inhibiting apoptosis induced by Aβ may lead to the development of a potential therapeutic target for AD treatment. κ‑carrageenan‑derived pentasaccharide (KCP) extracted from marine red algae is involved in a va...

journal_title：Molecular medicine reports

authors： Liu Y,Jiang L,Li X

更新日期：2017-01-01 00:00:00

abstract：:Metadherin (MTDH), also known as astrocyte-elevated gene-1, was first cloned in 2002 and has been confirmed as an oncogene in numerous types of cancer by previous studies. Overexpression of MTDH has been observed in multiple types of cancer, including breast, esophageal, prostate, cervical and non-small-cell lung canc...

journal_title：Molecular medicine reports

authors： Wei YB,Guo Q,Gao YL,Yan B,Wang Z,Yang JR,Liu W

更新日期：2015-07-01 00:00:00

abstract：:Misregulation of vascular endothelial growth factor A (VEGF‑A) has been implicated in numerous types of ovarian disease, such as polycystic ovarian syndrome, ovarian hyperstimulation syndrome, endometriosis and ovarian cancer. VEGF regulates blood vessel permeability and angiogenesis. In our previous study, VEGF‑regul...

journal_title：Molecular medicine reports

authors： Fang Y,Lu X,Liu L,Lin X,Sun M,Fu J,Xu S,Tan Y

更新日期：2016-06-01 00:00:00

abstract：:The expression and function of microRNA-497 (miR-497) has previously been reported in various types of human cancer; however, miR-497 has not previously been investigated in human osteosarcoma (OS). In the present study, the expression levels of miR‑497 were analyzed by reverse transcription‑quantitative polymerase ch...

journal_title：Molecular medicine reports

authors： Liu Q,Wang H,Singh A,Shou F

更新日期：2016-07-01 00:00:00

abstract：:Tubeimoside-1 (TBMS1), a triterpenoid saponin isolated from the tuber of Bolbostemma paniculatum (Maxim) Franquet, serves an universal suppressive role in multiple cancer types, including lung cancer. However, the mechanism involved in non‑small cell lung cancer (NSCLC) cells by which TBMS1 elicits its antitumor effec...

journal_title：Molecular medicine reports

authors： Shi H,Bi H,Sun X,Dong H,Jiang Y,Mu H,Liu G,Kong W,Gao R,Su J

更新日期：2018-03-01 00:00:00

abstract：:Micro (mi)RNAs are short non‑coding RNA molecules, which post‑transcriptionally regulate gene expression and exert key roles in cell growth, differentiation and apoptosis. In the present study, the mechanism and the function of miR‑1915‑3p in the apoptotic regulation of lung cancer cell lines (NCI‑H441 and NCI‑H1650) ...

journal_title：Molecular medicine reports

authors： Xu C,Li H,Zhang L,Jia T,Duan L,Lu C

更新日期：2016-01-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of chronic pulmonary inflammatory disease. Mucin5AC (MUC5AC) is a major component of airway gel‑forming mucin. Members of the Unc13 (Munc13) protein family act as important activators of granule exocytosis from various types of mammalian cells. The present s...

journal_title：Molecular medicine reports

authors： Xu R,Zhou J,Zhou XD,Li Q,Perelman JM,Kolosov VP

更新日期：2018-07-01 00:00:00

abstract：:The current study was performed with aim to investigate the fibroblast growth factor receptor 2 (FGFR2) gene in two Chinese families with two different forms of syndromic craniosynostosis, and to characterize their associated clinical features. Two families underwent complete ophthalmic examinations, and two patients ...

journal_title：Molecular medicine reports

authors： Lin Y,Gao H,Ai S,Eswarakumar JVP,Chen C,Zhu Y,Li T,Liu B,Liu X,Luo L,Jiang H,Li Y,Liang X,Jin C,Huang X,Lu L

更新日期：2017-10-01 00:00:00

abstract：:Centromere protein M (CENPM), a protein required for chromosome separation, is involved in in mitosis. However, little has been reported about the roles of CENPM in various types of cancer. The present study identified that the mRNA expression levels of CENPM were significantly upregulated in 14 types of human cancer ...

journal_title：Molecular medicine reports

authors： Liu Y,Yu W,Ren P,Zhang T

更新日期：2020-11-01 00:00:00

abstract：:Hypothermia is an effective neuroprotective treatment for brain injury caused by intracerebral hemorrhage (ICH). It is reported to reduce brain edema and neuronal cell death. Thrombin, a coagulation protease released from blood clots, is critical in brain edema formation following ICH. Protease activated receptor‑1 (P...

journal_title：Molecular medicine reports

authors： Gao D,Ding F,Lei G,Luan G,Zhang S,Li K,Wang D,Zhang L,Dai D

更新日期：2015-04-01 00:00:00

abstract：:Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enz...

journal_title：Molecular medicine reports

authors： Ahn JH,Noh Y,Shin BN,Kim SS,Park JH,Lee TK,Song M,Kim H,Lee JC,Yong JH,Kang IJ,Lee YL,Won MH,Kim JD

更新日期：2018-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is one of the most important causes of end‑stage renal disease. Astragaloside IV (AS-IV) is a saponin isolated from Astragalus membranaceus, which possesses various pharmacological activities. AS‑IV prevents podocyte apoptosis and ameliorates renal injury in DN; however, few studies have focu...

journal_title：Molecular medicine reports

authors： Yao XM,Liu YJ,Wang YM,Wang H,Zhu BB,Liang YP,Yao WG,Yu H,Wang NS,Zhang XM,Peng W

更新日期：2016-06-01 00:00:00

abstract：:The overexpression and hypersecretion of mucus is a hallmark of several chronic pulmonary inflammatory diseases, including chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis. Mucin 5ac (MUC5AC) is a major component of airway mucus. Annexin II (ANXII) has been reported to be expressed in various c...

journal_title：Molecular medicine reports

authors： Xu R,Li Q,Zhou X,Perelman JM,Kolosov VP

更新日期：2014-01-01 00:00:00

abstract：:Pentatricopeptide repeat domain protein 3 (PTCD3) is a mitochondrial RNA‑binding protein that serves a role in mitochondrial translation. PTCD3 was originally reported as an oncogene that is involved in breast cancer and lymphoma. However, the expression and function of PTCD3 in prostate cancer (PCa) are unknown. Ther...

journal_title：Molecular medicine reports

authors： Huang Y,Jiang G,Liang X,Lan Z,Su Z,Wu H,Weng J,Jiang X

更新日期：2018-10-01 00:00:00

abstract：:Cardiac fibrosis is considered an important pathological mechanism in the progression of cardiac remodeling and heart failure. Astragaloside IV (AsIV) is a major active ingredient in Astragalus membranaceus. In a preliminary experiment, it was demonstrated that this naturally occurring substance exhibited cardioprotec...

journal_title：Molecular medicine reports

authors： Dai H,Jia G,Lu M,Liang C,Wang Y,Wang H

更新日期：2017-04-01 00:00:00

abstract：:Multidrug resistance (MDR) has become a significant challenge in chemotherapeutic treatment of cancer. Quercetin, a naturally occurring flavonoid, has been found to possess anti-proliferative, anti-inflammatory and immunoregulatory bioactivities. The present study was performed to examine the effect of quercetin on hu...

journal_title：Molecular medicine reports

authors： Chen FY,Cao LF,Wan HX,Zhang MY,Cai JY,Shen LJ,Zhong JH,Zhong H

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to investigate the expression pattern of regenerating gene I (Reg I) in the lung and intestinal tissues of rats with acute necrotizing pancreatitis (ANP), as well as the correlation of Reg I expression with lung and intestinal injury. Sprague-Dawley rats were randomly allocated to control (n=...

journal_title：Molecular medicine reports

authors： Hu HL,Zhang Q,Kong B,Shi X

更新日期：2013-02-01 00:00:00

abstract：:Through searching for anti‑neuroinflammatory metabolites from Nardostachys jatamansi extracts, nardostachin was revealed to exert anti‑neuroinflammatory effects against lipopolysaccharide (LPS)‑induced overproduction of nitric oxide and prostaglandin E2 in BV2 and rat primary microglial cells. Furthermore, nardostachi...

journal_title：Molecular medicine reports

authors： Kim DC,Park JS,Yoon CS,Kim YC,Oh H

更新日期：2021-01-01 00:00:00

abstract：:Nerve growth factor (NGF) is expressed in the human corneal epithelium and stroma. It is an efficient therapy for human corneal ulcers caused by neurotropic disease. However, little is known about the molecular mechanism of NGF in healing human corneal epithelial diseases. Numerous microRNAs (miRNAs) are expressed in ...

journal_title：Molecular medicine reports

authors： Wu D,Qian T,Hong J,Li G,Shi W,Xu J

更新日期：2017-10-01 00:00:00

abstract：:Indoleamine 2,3‑dioxygenase (IDO), through L‑tryptophan depletion, activates general control non‑derepressible (GCN) 2 kinase and suppresses T‑cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of ...

journal_title：Molecular medicine reports

authors： Eleftheriadis T,Pissas G,Antoniadi G,Tsogka K,Sounidaki M,Liakopoulos V,Stefanidis I

更新日期：2016-01-01 00:00:00