Overexpression of G3BP1 facilitates the progression of colon cancer by activating β‑catenin signaling.

abstract：:The primary aim of the present study was to evaluate the effects of liraglutide on glucolipotoxicity‑induced liver cell apoptosis and the underlying mechanisms in Zucker diabetic fatty (ZDF) rats. The results revealed that liraglutide significantly decreased the body weight, hyperglycemia and hyperlipidemia of ZDF rat...

journal_title：Molecular medicine reports

authors： Guo J,Li C,Yang C,Li B,Wei J,Lin Y,Ye P,Hu G,Li J

更新日期：2018-06-01 00:00:00

abstract：:Longdan Xiegan Tang (LXT) is a mixture of herbal extracts commonly used in traditional Chinese medicine that may exert immunomodulatory effects for the treatment of autoimmune diseases. However, the detailed mechanisms that mediate the actions of LXT are unclear. The present study induced an experimental autoimmune uv...

journal_title：Molecular medicine reports

authors： Tang K,Guo D,Zhang L,Guo J,Zheng F,Si J,Bi H

更新日期：2016-09-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) is the most prevalent form of primary cardiomyopathy in humans and is a leading cause of heart failure and sudden cardiac death. Genetic abnormalities have been demonstrated to be a major contributor to the development of DCM. However, DCM is a genetically heterogeneous disease, and the ge...

journal_title：Molecular medicine reports

authors： Zhou YM,Dai XY,Huang RT,Xue S,Xu YJ,Qiu XB,Yang YQ

更新日期：2016-10-01 00:00:00

abstract：:Previous studies have suggested that the B‑cell lymphoma 2 (Bcl‑2) inhibitor, TW37, may induce apoptosis of the non‑small cell lung cancer cell line, H1975/epidermal growth factor receptor‑tyrosine kinase inhibitor (EGFR‑TKI), which exhibits secondary resistance to EGFR‑TKI. However, the effects of TW37 on H1975/EGFR‑...

journal_title：Molecular medicine reports

authors： Liu J,Yao X,Wu D,Ye Y,Wu Q,Liu S,Wu H

更新日期：2018-02-01 00:00:00

abstract：:Galectin‑3, a galactoside‑binding protein, is highly expressed in carotid plaques and plays an important role in the atherosclerotic lesions. The phenotype transformation of vascular smooth muscle cells is the basic pathological change of atherosclerosis. This study investigated the effects of exogenous galectin‑3 on ...

journal_title：Molecular medicine reports

authors： Tian L,Chen K,Cao J,Han Z,Wang Y,Gao L,Fan Y,Wang C

更新日期：2017-06-01 00:00:00

abstract：:The multipotent and easily accessible characteristics of dental pulp stem cells (DPSCs) make them a promising target for bone tissue engineering. Long non‑coding RNAs (lncRNAs) have an important role in the osteogenic differentiation of mesenchymal stem cells. Nevertheless, whether lncRNAs are involved in the osteogen...

journal_title：Molecular medicine reports

authors： Tao R,Li YX,Liu YK,Liu F,Zhou ZY

更新日期：2019-04-01 00:00:00

abstract：:Tumor necrosis factor‑related apoptosis-inducing ligand (TRAIL) is well known as a transmembrane cytokine and has been proposed as one of the most effective anti‑cancer therapeutic agents, owing to its efficiency to selectively induce cell death in a variety of tumor cells. Suppression of autophagy flux has been incre...

journal_title：Molecular medicine reports

authors： Nazim UM,Yin H,Park SY

更新日期：2019-02-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are endogenous transcribed RNA molecules without protein-coding potential, ranging between 200 and 100,000 nt in length. LncRNAs regulate the expression of specific genes in several ways, including guiding chromatin-remodeling, and affecting splicing, transcription or translation. The mut...

journal_title：Molecular medicine reports

authors： Li Y,Wang X

更新日期：2016-02-01 00:00:00

abstract：:The present study aimed to investigate whether brain death (BD) induces the activation of endoplasmic reticulum stress (ERS) and protein phosphatase 2A (PP2A), and reveal the possible association with BD‑induced liver cell apoptosis. A total of 30 healthy adult male Sprague‑Dawley rats were randomized into three group...

journal_title：Molecular medicine reports

authors： Lan J,Zhong Z,Wang Y,Xiong Y,Ye Q

更新日期：2020-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor. Studies have demonstrated that the toll‑like receptor 3 (TLR3)/interferon pathway is inhibitory in cancer cell proliferation, suggesting that the activation of this pathway may have therapeutic potential. In the present study, the inhib...

journal_title：Molecular medicine reports

authors： Xu YY,Chen L,Zhou JM,Wu YY,Zhu YY

更新日期：2013-10-01 00:00:00

abstract：:Human adipose tissue stem cells (ATSCs) can differentiate into various types of cell in response to lineage-specific induction factors. Reprogramming cells using nuclear and cytoplasmic extracts derived from another type of somatic cell is an effective method of producing specific types of differentiated cell. In the ...

journal_title：Molecular medicine reports

authors： Xie F,Tang X,Zhang Q,Deng C

更新日期：2015-01-01 00:00:00

abstract：:Prostaglandin E2 has exhibited pleiotropic effects in the regulation of glomerulosclerosis progression through its four receptors. The current study aimed to evaluate the effect of prostaglandin receptor EP4 on mesangial cell proliferation. In vivo, 5/6 nephrectomy was introduced into EP4+/‑ and wild‑type (WT) mice. C...

journal_title：Molecular medicine reports

authors： Cao Y,Pan T,Chen X,Wu J,Guo N,Wang B

更新日期：2018-12-01 00:00:00

abstract：:Hypertension affects one billion people worldwide and is an independent risk factor for death after acute coronary syndrome (ACS). The aim of this study was to examine the prevalence and medical treatment of hypertension among 1,301 ACS patients enrolled into the Chinese registry of acute coronary events (CRACE) trial...

journal_title：Molecular medicine reports

authors： Lin Y,Pan W,Ning S,Song X,Jin Z,Lv S

更新日期：2013-07-01 00:00:00

abstract：:Metabolic syndrome arises from a combination of disorders that increase the risk of cardiovascular disease and diabetes. In previous studies, it was observed that overexpression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) induced obesity and the insulin resistance that accompanies metabolic syndrome in roden...

journal_title：Molecular medicine reports

authors： Jung EM,An BS,Kim YK,Jeong YH,Hwang WS,Jeung EB

更新日期：2013-09-01 00:00:00

abstract：:Pancreatic carcinoma is one of the leading causes of cancer mortality worldwide, although the molecular mechanisms of this disease are poorly understood. The aim of this study was to examine the expression of cyclin-dependent kinase inhibitors (CDKIs) and the epigenetic modification...

journal_title：Molecular medicine reports

authors： Li G,Ji Y,Liu C,Li J,Zhou Y

更新日期：2012-04-01 00:00:00

abstract：:According to the results of the first genome-wide association study of ankylosing spondylitis (AS), endoplasmic reticulum aminopeptidase 1 (ERAP1) may serve an important role. However, a number of case-control studies have not been able to replicate this result using the same genetic markers. In the present study, the...

journal_title：Molecular medicine reports

authors： Wang X,Ma J,Ma J,Wen Y,Meng L,Yang H,Zhang R,Hao D

更新日期：2017-11-01 00:00:00

abstract：:Lipids extracted from Halocynthia roretzi contain n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid, as well as carotenoids. The aim of the present study was to evaluate the effect of H. roretzi lipids on white adipose tissue (WAT) weight and high blood glucose levels in diabetic/o...

journal_title：Molecular medicine reports

authors： Mikami N,Hosokawa M,Miyashita K

更新日期：2010-05-01 00:00:00

abstract：:Postmenopausal osteoporosis is a common systemic skeletal disease that is associated with estrogen‑deficiency. Bone loss associated with bisphosphonates therapy can increase the risk of developing oral osteonecrosis. Recent studies have indicated that enoxacin may inhibit osteoclast formation and bone resorption via a...

journal_title：Molecular medicine reports

authors： Zhang X,Xu X,Liu X,Mao C,Qin A,Lu E

更新日期：2018-02-01 00:00:00

abstract：:Soy milk, which is produced from whole soybeans, contains a variety of biologically active components. Isoflavones are a class of soy-derived phytoestrogens with beneficial effects, among which genistein (GEN) has been previously indicated to reduce the risk of prostate cancer. The present study evaluated the effects ...

journal_title：Molecular medicine reports

authors： Kang NH,Shin HC,Oh S,Lee KH,Lee YB,Choi KC

更新日期：2016-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most malignant types of tumor worldwide with a high rate of mortality. Diosmetin (DIOS) exhibits various activities, including anticancer activities. However, the role of DIOS in the metastasis of HCC, and its underlying molecular mechanism, remain to be fully elucidated. I...

journal_title：Molecular medicine reports

authors： Liu J,Wen X,Liu B,Zhang Q,Zhang J,Miao H,Zhu R

更新日期：2016-03-01 00:00:00

abstract：:Placental mesenchymal stem cells (PMSCs) have important biological properties and the potential for application in numerous clinical fields, including hematopoietic stem cell transplantation and myocardial repair. There are two types of MSCs in the placenta, amniotic mesenchymal stem cells (AMSCs) and chorion mesenchy...

journal_title：Molecular medicine reports

authors： Li F,Xu Y,Xu X,Xu B,Zhao J,Zhang X

更新日期：2014-07-01 00:00:00

abstract：:The purpose of the present study was to examine the effects of myricetin on reducing cerebral ischemia injury in a rat model. A rat model of permanent middle cerebral artery occlusion (pMCAO) was used in the present study. Rats were randomized into the following five groups: Sham, model, low‑myricetin (1 mg/kg), mediu...

journal_title：Molecular medicine reports

authors： Sun L,Xu P,Fu T,Huang X,Song J,Chen M,Tian X,Yin H,Han J

更新日期：2018-02-01 00:00:00

abstract：:In order to evaluate SCN2A as a candidate gene for epileptic susceptibility and the use of a Cu-Zn superoxide dismutase (SOD) supplement as a potential therapy for epilepsy, SCN2A expression in the cortex and the correlation between SCN2A and Cu-Zn SOD in SH-SY5Y cells were examined. SCN2A expression and the concentra...

journal_title：Molecular medicine reports

authors： Xiang J,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:The present study aimed to determine the profile of differentially expressed circular RNAs (circRNAs) in infertile patients treated with acupuncture and moxibustion and verify the role of acupuncture and moxibustion in altering endometrial receptivity (ER). High‑throughput RNA sequencing and bioinformatics analysis of...

journal_title：Molecular medicine reports

authors： Shen J,Chen L,Cheng J,Jin X,Mu Y,Li Q,Xia L,Gao Y,Xia Y

更新日期：2019-08-01 00:00:00

abstract：:Pneumonia accounts for ~1.3 million mortalities in children per year worldwide. MicroRNAs are implicated in several diseases, including cancer and pneumonia; however, the role of let7f‑5p in pneumonia is not completely understood. In the present study, lipopolysaccharide (LPS) was used to establish an in vitro pneumon...

journal_title：Molecular medicine reports

authors： Xu L,Song Q,Ouyang Z,Zhang X,Zhang C

更新日期：2021-02-01 00:00:00

abstract：:Several environmental contaminants have been linked to the development of diabetes and increased diabetes‑associated mortality. Perfluorooctanoic acid (PFOA) is a widely used perfluoroalkane found in surfactants and lubricants, and in processing aids used in the production of polymers. Furthermore, PFOA has been detec...

journal_title：Molecular medicine reports

authors： Suh KS,Choi EM,Kim YJ,Hong SM,Park SY,Rhee SY,Oh S,Kim SW,Pak YK,Choe W,Chon S

更新日期：2017-06-01 00:00:00

abstract：:B7-H1, a recently described B7 family member, has been reported to negatively regulate T-cell function in most cancer cells. In this study, we sought to investigate B7-H1 expression in four uveal melanoma (UM) cells (OCM1, SP6.5, OM431 and VUP) to determine the functional significance of B7-H1 expression in T-cell imm...

journal_title：Molecular medicine reports

authors： Jia R,Jiao Z,Xu X,Wang J,Zhou Y,Song X,Ge S,Fan X

更新日期：2011-01-01 00:00:00

abstract：:Signal transducer and activator of transcription 3 (STAT3) plays an important role in tumor cell survival and proliferation and thus has become a major focus in the development of anti-cancer therapies. Patrinia scabiosaefolia has been used for the treatment of various types of cancer. However, the precise mechanism o...

journal_title：Molecular medicine reports

authors： Peng J,Chen Y,Lin J,Zhuang Q,Xu W,Hong Z,Sferra TJ

更新日期：2011-03-01 00:00:00

abstract：:Advanced glycosylation end-product specific receptor (AGER) is a multi-ligand cell surface receptor abnormally expressed in lung cancer, and is a member of the immunoglobulin superfamily. Therefore, this study aimed to explore the effect of AGER on the biological behavior of non‑small cell lung cancer (NSCLC) H1299 ce...

journal_title：Molecular medicine reports

authors： Wang Q,Zhu W,Xiao G,Ding M,Chang J,Liao H

更新日期：2020-08-01 00:00:00

abstract：:Thymidylate synthase, as a rate-limiting step in DNA synthesis, catalyses the conversion of dUMP into dTMP using 5,10-methylenotetrahydrofolate as the methyl donor. Two polymorphisms have been described in this gene: a repeat polymorphism in the 5' promoter enhancer region (3R versus 2R) and a 6 bp deletion in the 3' ...

journal_title：Molecular medicine reports

authors： Carmona B,Guerreiro C,Cravo M,Nobre-Leitão C,Brito M

更新日期：2008-09-01 00:00:00