Effects of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in the Treatment of Goblet Cell Carcinoma: A Prospective Cohort Study.

Abstract:

BACKGROUND:Goblet cell carcinoma (GCC) of the appendix is a rare disease. Treatment options vary according to disease staging. Cytoreductive surgery in combination with hyperthermic intraperitoneal chemotherapy (CRS + HIPEC) may improve survival in patients with peritoneal spreading. OBJECTIVE:The aim of this study was to examine the prognosis of patients with appendiceal GCC treated per protocol, and to evaluate the results of CRS+HIPEC in cases of peritoneal spreading. METHODS:From 2009 to 2016, a total of 48 GCC patients were referred to the European Neuroendocrine Tumour Center of Excellence, Aarhus University Hospital. All patients received treatment per protocol according to disease staging. In patients with localized disease, the treatment was a right hemicolectomy. Patients with peritoneal spread who met the inclusion criteria for CRS + HIPEC, as well as patients with high-risk features of developing peritoneal spread, received CRS + HIPEC. If too-extensive disease was found, palliative chemotherapy was offered. RESULTS:Overall survival for patients with localized disease (n = 6) or deemed at risk of peritoneal spread (n = 8) was 100% after a median follow-up of 3.5 years. In patients with peritoneal spread and eligible for CRS+HIPEC(n = 27), the median survival was 3.2 years [95% confidence interval (CI) 2.3-4.1] and the 5-year survival rate was 57%. In contrast, the median survival for patients with too-extensive intraperitoneal disease (n = 7) was 1.3 years (95% CI 0.6-2.0), with a 3-year survival rate of 20%. CONCLUSIONS:Long-term survival can be achieved in patients with peritoneal spread treated with CRS + HIPEC. CRS+HIPEC was associated with a favorable outcome in GCC patients at high-risk of developing peritoneal spread.

journal_name

Ann Surg Oncol

authors

Madsen AH,Ladekarl M,Villadsen GE,Grønbæk H,Sørensen MM,Stribolt K,Verwaal VJ,Iversen LH

doi

10.1245/s10434-017-6272-x

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

422-430

issue

2

eissn

1068-9265

issn

1534-4681

pii

10.1245/s10434-017-6272-x

journal_volume

25

pub_type

杂志文章
  • Dickkopf-1 expression as a marker for predicting clinical outcome in esophageal squamous cell carcinoma.

    abstract:BACKGROUND AND OBJECTIVES:Dickkopf-1 (DKK1) is the inhibitor of the canonical Wnt signaling pathway, however it is highly transactivated in various cancers, suggesting the presence of unknown mechanism. Its implication in human esophageal squamous cell carcinoma (ESCC) has not been sufficiently investigated. PATIENTS ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-009-0476-7

    authors: Makino T,Yamasaki M,Takemasa I,Takeno A,Nakamura Y,Miyata H,Takiguchi S,Fujiwara Y,Matsuura N,Mori M,Doki Y

    更新日期:2009-07-01 00:00:00

  • Rationale for elective contralateral mastectomy with immediate bilateral reconstruction.

    abstract:BACKGROUND:Women with breast cancer treated by mastectomy with immediate breast reconstruction can get exceptionally good results if the reconstruction is performed with autogenous tissue using the transverse rectus abdominis myocutaneous (TRAM) flap. Bilateral reconstruction with TRAM flaps is also possible, but only ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02303609

    authors: Kroll SS,Miller MJ,Schusterman MA,Reece GP,Singletary SE,Ames F

    更新日期:1994-11-01 00:00:00

  • The Use and Benefit of Adjuvant Radiotherapy in Parathyroid Carcinoma: A National Cancer Database Analysis.

    abstract:BACKGROUND:The routine use of external beam radiotherapy (EBRT) is not recommended for parathyroid carcinoma (PC). However, case series have demonstrated a potential benefit in preventing local recurrence with EBRT. We aimed to characterize the patient population treated with EBRT and identify any impact of EBRT on ove...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08825-8

    authors: Limberg J,Stefanova D,Ullmann TM,Thiesmeyer JW,Bains S,Beninato T,Zarnegar R,Fahey TJ 3rd,Finnerty BM

    更新日期:2021-01-01 00:00:00

  • Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration.

    abstract:BACKGROUND:Male breast cancer accounts for less than 1% of all breast cancers, yet males have a worse prognosis than females with breast cancer. METHODS:Using the 1988-2003 Surveillance, Epidemiology, and End Results Program data, we conducted a retrospective, population-based cohort study to investigate stage-specifi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-1468-3

    authors: Gnerlich JL,Deshpande AD,Jeffe DB,Seelam S,Kimbuende E,Margenthaler JA

    更新日期:2011-07-01 00:00:00

  • Shear wave elastography in evaluation of cervical lymph node metastasis of papillary thyroid carcinoma: elasticity index as a prognostic implication.

    abstract:PURPOSE:The aim of this study was to evaluate the usefulness of shear wave elastography (SWE) for predicting cervical lymph node (LN) metastasis and the prognostic implication of SWE as histopathologic factors of papillary thyroid carcinoma (PTC). METHODS:Eighty-four LNs of 66 patients with PTC underwent B-mode ultras...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3627-4

    authors: Jung WS,Kim JA,Son EJ,Youk JH,Park CS

    更新日期:2015-01-01 00:00:00

  • Reconstruction patterns in a single institution cohort of women undergoing mastectomy for breast cancer.

    abstract:OBJECTIVES:The purpose of the current study was to conduct a patient-centered investigation of reconstruction practices following mastectomy at our institution. METHODS:A questionnaire was administered to patients who underwent unilateral or bilateral mastectomy for breast cancer from 2006 to 2010. The survey queried ...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-012-2530-0

    authors: Elmore L,Myckatyn TM,Gao F,Fisher CS,Atkins J,Martin-Dunlap TM,Margenthaler JA

    更新日期:2012-10-01 00:00:00

  • Peritoneal lavage cytology in gastric cancer: an independent predictor of outcome.

    abstract:BACKGROUND:The prevalence and significance of free cancer cells in the peritoneal cavity of clinically M0 gastric cancer patients is unknown. We reviewed our results with peritoneal washings to determine (1) the prevalence of positive cytology in M0 and M1 disease and (2) the influence of positive cytology on the patte...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303859

    authors: Burke EC,Karpeh MS Jr,Conlon KC,Brennan MF

    更新日期:1998-07-01 00:00:00

  • Survival benefit of hyperthermic intraperitoneal chemotherapy for recurrent ovarian cancer: a multi-institutional case control study.

    abstract:BACKGROUND:Hyperthermic intraperitoneal chemotherapy (HIPEC) and complete surgical removal of the tumor, in relapsing patients may provide a clinical benefit. There is no consensus considering the place of HIPEC for patients who had first ovarian cancer relapse. To assess for possible efficacy of HIPEC on overall survi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1245/s10434-014-3693-7

    authors: Le Brun JF,Campion L,Berton-Rigaud D,Lorimier G,Marchal F,Ferron G,Oger AS,Dravet F,Jaffre I,Classe JM

    更新日期:2014-10-01 00:00:00

  • ASO Author Reflections: Addressing Surgery-Specific Risk Factors Influencing Time to Chemotherapy in Breast Cancer.

    abstract:: ...

    journal_title:Annals of surgical oncology

    pub_type: 评论,杂志文章

    doi:10.1245/s10434-018-6852-4

    authors: James TA

    更新日期:2018-12-01 00:00:00

  • Prognostic value of cytokeratin-positive bone marrow cells of gastric cancer patients.

    abstract:BACKGROUND:Epithelial cells in the bone marrow of patients with gastric cancer suggest tumor dissemination; however, their prognostic implications are controversial. We prospectively evaluated the correlation of bone marrow findings, recurrence rate, and disease-free survival after long-term follow-up. METHODS:Bone ma...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-006-9039-3

    authors: Gretschel S,Schick C,Schneider U,Estevez-Schwarz L,Bembenek A,Schlag PM

    更新日期:2007-02-01 00:00:00

  • Optimal submucosal invasion of early gastric cancer for endoscopic resection.

    abstract:BACKGROUND:A small differentiated gastric cancer with minute submucosal invasion after endoscopic resection is regarded as the curative resection criterion of an expanded indication. However, recent studies have shown a high incidence of lymph node metastasis in those meeting the expanded criteria. The aim of this stud...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4308-z

    authors: Eom BW,Yu JS,Ryu KW,Kook MC,Kim YI,Cho SJ,Lee JY,Kim CG,Choi IJ,Yoon HM,Kim YW

    更新日期:2015-01-01 00:00:00

  • Intraperitoneal Administration of Paclitaxel Combined with S-1 Plus Oxaliplatin as Induction Therapy for Patients with Advanced Gastric Cancer with Peritoneal Metastases.

    abstract:BACKGROUND:Intraperitoneal (IP) administration of paclitaxel (PTX) has a great pharmacokinetic advantage to control peritoneal lesions and can be combined with various systemic chemotherapies. In this study, we evaluate the efficacy and tolerability of a combination of IP-PTX and systemic S-1/oxaliplatin (SOX) for indu...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-09388-4

    authors: Saito S,Yamaguchi H,Ohzawa H,Miyato H,Kanamaru R,Kurashina K,Hosoya Y,Lefor AK,Sata N,Kitayama J

    更新日期:2020-12-03 00:00:00

  • Intraoperative epidural analgesia prevents the early proinflammatory response to surgical trauma. Results from a prospective randomized clinical trial of intraoperative epidural versus general analgesia.

    abstract:BACKGROUND:The intraoperative epidural analgesia (EA) has the potential to reduce stress response to surgical trauma which induces a transient immunoactivation that has a negative impact on the outcome. This study investigates the effect of intraoperative EA versus intravenous analgesia (IA) on the immune function. ME...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1245/s10434-011-1700-9

    authors: Moselli NM,Baricocchi E,Ribero D,Sottile A,Suita L,Debernardi F

    更新日期:2011-10-01 00:00:00

  • The surgeon's role in cancer prevention. The model in colorectal carcinoma.

    abstract::Cancer Prevention is an emerging field, capturing the old traditional concept of anticipating the development of a major disease and preventing its full impact by early detection, treatment, or aborting the tumorigenic process by a "molecular vaccine" and alleviating the full impact of the disease. Surgeons are import...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-007-9485-6

    authors: Chu DZ,Gibson G,David D,Yen Y

    更新日期:2007-11-01 00:00:00

  • Intraoperative Margin Management in Breast-Conserving Surgery: A Systematic Review of the Literature.

    abstract:BACKGROUND:Breast surgeons have a wide variety of intraoperative techniques available to help achieve low rates for positive margins of excision, with variable levels of evidence. METHODS:A systematic review of the medical literature from 1995 to July 2016 was conducted, with 434 abstracts identified and evaluated. Th...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,meta分析

    doi:10.1245/s10434-016-5756-4

    authors: Gray RJ,Pockaj BA,Garvey E,Blair S

    更新日期:2018-01-01 00:00:00

  • Predictive Potential of Preoperative Nutritional Status in Long-Term Outcome Projections for Patients with Gastric Cancer.

    abstract:BACKGROUND:Preoperative nutritional status not only correlates with the incidence of postoperative complications but also may be indicative of long-term outcomes for patients with cancer. The impact of preoperative nutritional status on outcomes for patients undergoing gastrectomy for gastric cancer (GC) was investigat...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4814-7

    authors: Sakurai K,Ohira M,Tamura T,Toyokawa T,Amano R,Kubo N,Tanaka H,Muguruma K,Yashiro M,Maeda K,Hirakawa K

    更新日期:2016-02-01 00:00:00

  • Outcomes of Sentinel Lymph Node-Positive Breast Cancer Patients Treated with Mastectomy Without Axillary Therapy.

    abstract:PURPOSE:Early-stage breast cancer patients with minimal axillary disease identified by sentinel lymph node dissection (SLND) have low regional recurrence rates when treated with breast-conserving surgery and radiation therapy (XRT) and many avoid a completion axillary lymph node dissection (CLND). As the incidence of t...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5605-5

    authors: FitzSullivan E,Bassett RL,Kuerer HM,Mittendorf EA,Yi M,Hunt KK,Babiera GV,Caudle AS,Black DM,Bedrosian I,Reyna C,Teshome M,Meric-Bernstam F,Hwang R

    更新日期:2017-03-01 00:00:00

  • Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion.

    abstract:BACKGROUND:Isolated limb infusion (ILI) is a recently described minimally invasive technique developed in Australia for delivering regional chemotherapy. This study examined the efficacy and toxicity of ILI, compared to hyperthermic isolated limb perfusion (HILP), in treating extremity in-transit melanoma. METHODS:Var...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-008-9988-9

    authors: Beasley GM,Petersen RP,Yoo J,McMahon N,Aloia T,Petros W,Sanders G,Cheng TY,Pruitt SK,Seigler H,Tyler DS

    更新日期:2008-08-01 00:00:00

  • Survival of Patients with Uterine Carcinosarcoma Undergoing Sentinel Lymph Node Mapping.

    abstract:PURPOSE:This study was designed to evaluate the outcome of patients with uterine carcinosarcoma undergoing sentinel lymph node (SLN) mapping. METHODS:A prospectively maintained database was reviewed for all women with uterine cancer treated at our institution from January 1, 1998 to August 31, 2014. Patients were grou...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-015-4612-2

    authors: Schiavone MB,Zivanovic O,Zhou Q,Leitao MM Jr,Levine DA,Soslow RA,Alektiar KM,Makker V,Iasonos A,Abu-Rustum NR

    更新日期:2016-01-01 00:00:00

  • Prophylactic lymphadenectomy of neck level II in clinically node-positive papillary thyroid carcinoma.

    abstract:BACKGROUND:The purpose of this study was to examine the frequency, pattern, and predictive factors associated with occult level II lymph node (LN) metastases in papillary thyroid carcinoma (PTC) patients with clinically metastatic lymph nodes in the lateral neck (level III, IV, and/or V) by preoperative ultrasonography...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-010-0958-7

    authors: Koo BS,Seo ST,Lee GH,Kim JM,Choi EC,Lim YC

    更新日期:2010-06-01 00:00:00

  • The 1999 James Ewing Lecture: in pursuit of molecules of oncogenesis and neoplastic therapy.

    abstract::Breast cancer is a progressive, phenotypic, genetic and epigenetic alteration, induced by various stimulants of which the principal steroid hormone, estrogen, initiates and promotes neoplastic transformation of normal ductal mammary epithelium to acquire distinct biochemical and molecular characteristics. The molecula...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1007/s10434-999-0528-z

    authors: Bland KI

    更新日期:1999-09-01 00:00:00

  • Initial results with preoperative tattooing of biopsied axillary lymph nodes and correlation to sentinel lymph nodes in breast cancer patients.

    abstract:BACKGROUND:Pretreatment evaluation of axillary lymph nodes (ALNs) and marking of biopsied nodes in patients with newly diagnosed breast cancer is becoming routine practice. We sought to test tattooing of biopsied ALNs with a sterile black carbon suspension (Spot™). The intraoperative success of identifying tattooed ALN...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-4034-6

    authors: Choy N,Lipson J,Porter C,Ozawa M,Kieryn A,Pal S,Kao J,Trinh L,Wheeler A,Ikeda D,Jensen K,Allison K,Wapnir I

    更新日期:2015-02-01 00:00:00

  • Demonstration of second-tier lymph nodes during preoperative lymphoscintigraphy for melanoma: incidence varies with primary tumor site.

    abstract:BACKGROUND:Preoperative cutaneous lymphoscintigraphy (LS) to identify sentinel (first-tier) lymph nodes was performed in 250 consecutive melanoma patients before wide local excision only or wide local excision with sentinel node biopsy. METHODS:The location of the sentinel nodes was marked on the overlying skin in all...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1007/BF02303644

    authors: Uren RF,Howman-Giles RB,Thompson JF

    更新日期:1998-09-01 00:00:00

  • ROS1 receptor tyrosine kinase, a druggable target, is frequently overexpressed in non-small cell lung carcinomas via genetic and epigenetic mechanisms.

    abstract:BACKGROUND:Microarray analyses have revealed significantly elevated expression of the proto-oncogene ROS1 receptor tyrosine kinase in 20-30% of non-small cell lung carcinomas (NSCLC). Selective and potent ROS1 kinase inhibitors have recently been developed and oncogenic rearrangement of ROS1 in NSCLC identified. METHO...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-012-2553-6

    authors: Lee HJ,Seol HS,Kim JY,Chun SM,Suh YA,Park YS,Kim SW,Choi CM,Park SI,Kim DK,Kim YH,Jang SJ

    更新日期:2013-01-01 00:00:00

  • Impact of Neoadjuvant Chemotherapy on Clinical Risk Scores and Survival in Patients with Colorectal Liver Metastases.

    abstract:BACKGROUND:Several clinical risk scores for patients with colorectal liver metastases (CLM) were established in cohorts of patients undergoing liver resection (LR) without neoadjuvant chemotherapy (NAC). The purpose of the study was to evaluate the predictive values of four common risk scores in the setting of NAC and ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-016-5615-3

    authors: Wimmer K,Schwarz C,Szabo C,Bodingbauer M,Tamandl D,Mittlböck M,Kaczirek K

    更新日期:2017-01-01 00:00:00

  • A systematic review of microvascular invasion in hepatocellular carcinoma: diagnostic and prognostic variability.

    abstract::Selected patients with hepatocellular carcinoma are candidates to receive potentially curative treatments, such as hepatic resection or liver transplantation, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion is a histological feature of hepatocellular carcinoma related to aggressive bi...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章,评审

    doi:10.1245/s10434-012-2513-1

    authors: Rodríguez-Perálvarez M,Luong TV,Andreana L,Meyer T,Dhillon AP,Burroughs AK

    更新日期:2013-01-01 00:00:00

  • Serum matrilysin levels predict outcome in curatively resected colorectal cancer patients.

    abstract:BACKGROUND:Matrix metalloproteinase 7 (MMP-7) is involved in invasion, metastasis, growth, and angiogenesis. The aim of this study is to assess the prognostic role of serum MMP-7 in curatively resected colorectal cancer (CRC). MATERIALS AND METHODS:Patients undergoing resection for CRC (n = 175) were recruited from Ju...

    journal_title:Annals of surgical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1245/s10434-009-0405-9

    authors: Martínez-Fernandez A,García-Albeniz X,Pineda E,Visa L,Gallego R,Codony-Servat J,Augé JM,Longarón R,Gascón P,Lacy A,Castells A,Maurel J

    更新日期:2009-05-01 00:00:00

  • Treatment patterns and outcomes for patients with adrenocortical carcinoma associated with hospital case volume in the United States.

    abstract:BACKGROUND:Adrenocortical carcinoma (ACC) is a rare, aggressive disease with no apparent change in treatment or survival in the United States over the past two decades. Our objective was to determine whether treatment patterns or clinical outcomes vary by hospital case volume. METHODS:Patients with ACC were identified...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-014-3931-z

    authors: Gratian L,Pura J,Dinan M,Reed S,Scheri R,Roman S,Sosa JA

    更新日期:2014-10-01 00:00:00

  • A new policy regarding ovarian resection in young women treated for peritoneal carcinomatosis.

    abstract:OBJECTIVE:To appreciate if the ovaries can be preserved in selected young women with peritoneal carcinomatosis (PC). BACKGROUND:The traditional rule is to resect the ovaries systematically when PC is found at surgery. METHODS:A new policy was developed to preserve the ovaries when they were macroscopically normal in ...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-013-2879-8

    authors: Elias D,Duchalais E,Dartigues P,Duvillard P,Poirot C,Goéré D

    更新日期:2013-06-01 00:00:00

  • How Effective is Neoadjuvant Endocrine Therapy (NET) in Downstaging the Axilla and Achieving Breast-Conserving Surgery?

    abstract:BACKGROUND:Neoadjuvant endocrine therapy (NET) is effective in downstaging large hormone receptor-positive (HR+) breast cancers and increasing rates of breast-conserving surgery (BCS), but data regarding nodal pathologic complete response (pCR) are sparse. We reported nodal and breast downstaging rates with NET, and co...

    journal_title:Annals of surgical oncology

    pub_type: 杂志文章

    doi:10.1245/s10434-020-08888-7

    authors: Montagna G,Sevilimedu V,Fornier M,Jhaveri K,Morrow M,Pilewskie ML

    更新日期:2020-11-01 00:00:00