Immunome knowledge base (IKB): an integrated service for immunome research.

abstract：BACKGROUND:Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by the novel coronavirus SARS-CoV. The T cell epitopes of the SARS CoV spike protein are well known, but no systematic evaluation of the functional and structural roles of each residue has been reported for these antigenic epit...

journal_title：BMC immunology

authors： Huang J,Cao Y,Bu X,Wu C

更新日期：2012-09-10 00:00:00

abstract：BACKGROUND:Marginal zone (MZ) B cells play important roles in the early phases of humoral immune responses. In addition to possessing an inherent capacity to rapidly differentiate into antibody secreting cells, MZ B cells also help to regulate the fate of both T-independent and T-dependent blood-borne antigens in the s...

journal_title：BMC immunology

authors： Ferguson AR,Corley RB

更新日期：2005-04-18 00:00:00

abstract：BACKGROUND:The extracellular domains of cytokine receptors are released during inflammation, but little is known about the shedding of Toll-like receptors (TLR) and whether they can be used as diagnostic biomarkers. METHODS:The release of sTLR2 and sTLR4 was studied in in-vitro stimulations, as well as in-vivo during ...

journal_title：BMC immunology

authors： Ten Oever J,Kox M,van de Veerdonk FL,Mothapo KM,Slavcovici A,Jansen TL,Tweehuysen L,Giamarellos-Bourboulis EJ,Schneeberger PM,Wever PC,Stoffels M,Simon A,van der Meer JW,Johnson MD,Kullberg BJ,Pickkers P,Pachot A,Jooste

更新日期：2014-11-19 00:00:00

abstract：BACKGROUND:Toll-like receptor 2 (TLR2) plays a critical role in mediating inflammatory/immune responses against bacterial pathogens in lung. Streptococcus pneumoniae (S. pneumoniae) and nontypeable Haemophilus influenzae (NTHi) were previously reported to synergize with each other to induce inflammatory responses. Desp...

journal_title：BMC immunology

authors： Lim JH,Ha U,Sakai A,Woo CH,Kweon SM,Xu H,Li JD

更新日期：2008-07-29 00:00:00

abstract：BACKGROUND:Regulatory T cells (Treg) play a crucial role in maintaining immune homeostasis and self-tolerance. The immune suppressive effects of Tregs should however be limited in case effective immunity is required against pathogens or cancer cells. We previously found that the Toll-like receptor 2 (TLR2) agonist, Pam...

journal_title：BMC immunology

authors： van Maren WW,Nierkens S,Toonen LW,Bolscher JM,Sutmuller RP,Adema GJ

更新日期：2011-03-24 00:00:00

abstract：BACKGROUND:Recognition of pathogens by dendritic cells (DCs) through interaction with pattern recognition receptors, including Toll like receptors (TLR), is crucial for the initiation of appropriate polarized T helper (Th) cell responses. Yet, the characteristics and differences in molecular profiles of DCs with differ...

journal_title：BMC immunology

authors： van Riet E,Everts B,Retra K,Phylipsen M,van Hellemond JJ,Tielens AG,van der Kleij D,Hartgers FC,Yazdanbakhsh M

更新日期：2009-02-04 00:00:00

abstract：BACKGROUND:In genetically modified (GM) crops there is a risk that the inserted genes may introduce new allergens and/or adjuvants into the food and feed chain. The MON810 maize, expressing the insecticidal Cry1Ab toxin, is grown in many countries worldwide. In animal models, intranasal and intraperitoneal immunisation...

journal_title：BMC immunology

authors： Andreassen M,Bøhn T,Wikmark OG,Bodin J,Traavik T,Løvik M,Nygaard UC

更新日期：2016-05-04 00:00:00

abstract：BACKGROUND:Molecular mimicry between microbial antigens and host-proteins is one of the etiological enigmas for the occurrence of autoimmune diseases. T cells that recognize cross-reactive epitopes may trigger autoimmune reactions. Intriguingly, autoimmune diseases have been reported to be prevalent in tuberculosis end...

journal_title：BMC immunology

authors： Chodisetti SB,Rai PK,Gowthaman U,Pahari S,Agrewala JN

更新日期：2012-03-21 00:00:00

abstract：BACKGROUND:The bacterial biofilm at the gingival margin induces a host immune reaction. In this local inflammation epithelial cells defend the host against bacterial challenge. Porphyromonas gingivalis (P. gingivalis), a keystone pathogen, infects epithelial cells. The aim of this study was to investigate the activatio...

journal_title：BMC immunology

authors： Groeger S,Jarzina F,Domann E,Meyle J

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:Some patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) also have positivity of rheumatoid factor (RF). However, the clinical significance of this occurrence remains unknown in AAV patients. The aim of this study was to clarify an association between the presence of RF and c...

journal_title：BMC immunology

authors： Watanabe S,Gono T,Nishina K,Sugitani N,Watanabe E,Yabe H,Terai C

更新日期：2017-12-20 00:00:00

abstract：BACKGROUND:Respiratory burst function resulting in the release of reactive oxygen species such as superoxide anion (O2-) from neutrophils is one of the key mechanisms of the innate immune system, and maladaptive control of this mechanism is thought to play a pivotal role in the development of pathologies such as acute ...

journal_title：BMC immunology

authors： Tung JP,Fraser JF,Wood P,Fung YL

更新日期：2009-05-08 00:00:00

abstract：BACKGROUND:Human Papillomavirus, HPV, is the main etiological factor for cervical cancer. Different studies show that in women infected with HPV there is a positive correlation between lesion grade and number of infiltrating macrophages, as well as with IL-10 higher expression. Using a HPV16 associated tumor model in m...

journal_title：BMC immunology

authors： Bolpetti A,Silva JS,Villa LL,Lepique AP

更新日期：2010-06-07 00:00:00

abstract：BACKGROUND:Inappropriate activation of T lymphocytes plays an important role in perinatal complications. However, data on T lymphocyte activation markers of preterm infants is scarce. We investigated the association between gender, gestational and postnatal age, preeclampsia (PE), premature rupture of membranes (PROM) ...

journal_title：BMC immunology

authors： Sava F,Toldi G,Treszl A,Hajdú J,Harmath Á,Tulassay T,Vásárhelyi B

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:T-cells extravasation and CNS parenchyma infiltration during autoimmune neurodegenerative disease can be evoked by local antigen presenting cells. Studying the chemoattracting potential of spinal perivascular macrophages (SPM) during experimental allergic encephalomyelitis (EAE), we observed numerous infiltr...

journal_title：BMC immunology

authors： Hofmann N,Lachnit N,Streppel M,Witter B,Neiss WF,Guntinas-Lichius O,Angelov DN

更新日期：2002-08-26 00:00:00

abstract：BACKGROUND:Extracellular vesicles (EVs) are nano-sized particles secreted by most cells. EVs carry nucleic acids that hold promise as potential biomarkers in various diseases. Human immunodeficiency virus type 1 (HIV) infects CD4+ T cells and induces immune dysfunction, inflammation, and EV secretion, but little is kno...

journal_title：BMC immunology

authors： Chettimada S,Lorenz DR,Misra V,Wolinsky SM,Gabuzda D

更新日期：2020-11-11 00:00:00

abstract：BACKGROUND:Class I major histocompatibility complex (MHC) molecules bind, and present to T cells, short peptides derived from intracellular processing of proteins. The peptide repertoire of a specific molecule is to a large extent determined by the molecular structure accommodating so-called main anchor positions of th...

journal_title：BMC immunology

authors： Sidney J,Peters B,Frahm N,Brander C,Sette A

更新日期：2008-01-22 00:00:00

abstract：BACKGROUND:Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce IgE binding. It is suggested that these allergoid extracts also have...

journal_title：BMC immunology

authors： Urry ZL,Richards DF,Black C,Morales M,Carnés J,Hawrylowicz CM,Robinson DS

更新日期：2014-05-29 00:00:00

abstract：BACKGROUND:Macrophages are key players in the initiation, perpetuation and regulation of both innate and adaptive immune responses. They largely perform these roles through modulation of the expression of genes, especially those encoding cytokines. Murine bone marrow derived macrophages (BMDMs) are commonly used as a m...

journal_title：BMC immunology

authors： Tanaka A,To J,O'Brien B,Donnelly S,Lund M

更新日期：2017-10-03 00:00:00

abstract：BACKGROUND:Expressed in embryonic development, matrix metalloprotein-9 (MMP-9) is absent in most of developed adult tissues, but recurs in inflammation during tissue injury, wound healing, tumor formation and metastasis. Expression of MMP-9 is tightly controlled by extracellular cues including pro-inflammatory cytokine...

journal_title：BMC immunology

authors： Zhou L,Yan C,Gieling RG,Kida Y,Garner W,Li W,Han YP

更新日期：2009-03-19 00:00:00

abstract：BACKGROUND:Insulin dependent (i.e., "type 1") diabetes mellitus (T1DM) is considered to be a T cell mediated disease in which TH1 and Tc autoreactive cells attack the pancreatic islets. Among the beta-cell antigens implicated in T1DM, glutamic acid decarboxylase (GAD) 65 appears to play a key role in the development of...

journal_title：BMC immunology

authors： Pedotti R,Sanna M,Tsai M,DeVoss J,Steinman L,McDevitt H,Galli SJ

更新日期：2003-02-22 00:00:00

abstract：BACKGROUND:Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 co-i...

journal_title：BMC immunology

authors： Matavele Chissumba R,Silva-Barbosa SD,Augusto Â,Maueia C,Mabunda N,Gudo ES Jr,Bhatt N,Jani I,Savino W

更新日期：2015-09-02 00:00:00

abstract：BACKGROUND:Tuberculous pleural effusion (TPE) is one of the most common forms of extrapulmonary tuberculosis. Because most studies of TPE focused on the pleural space, little information regarding lung parenchyma is available. We therefore aimed to investigate immune responses in the lung parenchyma of TPE patients wit...

journal_title：BMC immunology

authors： Qama D,Choi WI,Kwon KY

更新日期：2012-08-13 00:00:00

abstract：BACKGROUND:Anthrax lethal toxin (LT), produced by the Gram-positive bacterium Bacillus anthracis, is a highly effective zinc dependent metalloprotease that cleaves the N-terminus of mitogen-activated protein kinase kinases (MAPKK or MEKs) and is known to play a role in impairing the host immune system during an inhalat...

journal_title：BMC immunology

authors： Chauncey KM,Lopez MC,Sidhu G,Szarowicz SE,Baker HV,Quinn C,Southwick FS

更新日期：2012-07-02 00:00:00

abstract：BACKGROUND:Parasite-specific IgE levels correlate with human resistance to reinfection with Schistosoma spp. after chemotherapy. Although the role of eosinophils in schistosomiasis has been the focus of a great deal of important research, the involvement of other Fcepsilon receptor-bearing cells, such as mast cells and...

journal_title：BMC immunology

authors： Satti MZ,Cahen P,Skov PS,Joseph S,Jones FM,Fitzsimmons C,Hoffmann KF,Reimert C,Kariuki HC,Kazibwe F,Mwatha JK,Kimani G,Vennervald BJ,Ouma JH,Kabatereine NB,Dunne DW

更新日期：2004-04-21 00:00:00

abstract：BACKGROUND:Dysregulation of the immune system has been shown to occur during spaceflight, although the detailed nature of the phenomenon and the clinical risks for exploration class missions have yet to be established. Also, the growing clinical significance of immune system evaluation combined with epidemic infectious...

journal_title：BMC immunology

authors： Crucian B,Lee P,Stowe R,Jones J,Effenhauser R,Widen R,Sams C

更新日期：2007-05-23 00:00:00

abstract：BACKGROUND:Besides their prominent role in the elimination of infected or malignantly transformed cells, natural killer (NK) cells serve as modulators of adaptive immune responses. Enhancing bidirectional crosstalk between NK cells and dendritic cells (DC) is considered a promising tool to potentiate cancer vaccines. W...

journal_title：BMC immunology

authors： Oth T,Habets THPM,Germeraad WTV,Zonneveld MI,Bos GMJ,Vanderlocht J

更新日期：2018-02-13 00:00:00

abstract：BACKGROUND:Deer mice (Peromyscus maniculatus) are the most common mammals in North America and are reservoirs for several zoonotic agents, including Sin Nombre virus (SNV), the principal etiologic agent of hantavirus cardiopulmonary syndrome (HCPS) in North America. Unlike human HCPS patients, SNV-infected deer mice sh...

journal_title：BMC immunology

authors： Oko L,Aduddell-Swope B,Willis D,Hamor R,Coons TA,Hjelle B,Schountz T

更新日期：2006-08-17 00:00:00

abstract：BACKGROUND:Burkholderia pseudomallei is the causative agent of melioidosis, an emerging bacterial infectious disease in tropical and subtropical areas. We recently showed that NADPH oxidase but not nitric oxide (NO) contributes to resistance in innately resistant C57BL/6 mice in a B. pseudomallei respiratory infection ...

journal_title：BMC immunology

authors： Breitbach K,Wongprompitak P,Steinmetz I

更新日期：2011-03-16 00:00:00

abstract：BACKGROUND:Cryopreservation of peripheral blood mononuclear cells has been used to preserve and standardize immunologic measurements for multicenter studies, however, effects of cryopreservation on cytokine responses are incompletely understood. In designing immunologic studies for a new multicenter birth cohort study ...

journal_title：BMC immunology

authors： Shreffler WG,Visness CM,Burger M,Cruikshank WW,Lederman HM,de la Morena M,Grindle K,Calatroni A,Sampson HA,Gern JE

更新日期：2006-12-12 00:00:00

abstract：BACKGROUND:Although plasmid DNA encoding an antigen from pathogens or tumor cells has been widely studied as vaccine, the use of plasmid vector (without insert) as therapeutic agent requires further investigation. RESULTS:Here, we showed that plasmid DNA (pcDNA3) at low doses inhibits the production of IL-6 and TNF-α ...

journal_title：BMC immunology

authors： Malardo T,Batalhão ME,Panunto-Castelo A,Almeida LP,Padilha E,Fontoura IC,Silva CL,Carnio EC,Coelho-Castelo AA

更新日期：2012-11-08 00:00:00