Abstract：
:Papaveris pericarpium, a natural source of morphine and codeine, is the principal active component in many antitussive traditional Chinese medicines. We herein report the first PK study of papaveris pericarpium in human plasma and urine following oral administration of single (15, 30, 60 mL) and multiple dose (15 mL) of Qiangli Pipa Syrup (MOR 0.1 mg/mL, COD 0.028 mg/mL) by monitoring morphine and codeine using a HPLC-MS/MS method. Their Tmax and t1/2 values are independent of dosages, while the AUC0-t linearly increased with higher dosages, indicating linear PK characteristics. AUC0-t increased obviously after multiple doses, indicating possible risk of accumulative toxicity. Urine studies suggested risks of positive opiate drug tests with a cutoff of 300 ng/mL, which lasted 6-14 h at different doses. These results provide important information for clinical safety, efficacy and rational drug use of Qiangli Pipa Syrup and also guide the related judicial expertise of its administration.
journal_name
J Forensic Scijournal_title
Journal of forensic sciencesauthors
Guo BB,Zhang YQ,Wang SF,Ding JS,Zhou WHdoi
10.1111/1556-4029.13696subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1221-1228issue
4eissn
0022-1198issn
1556-4029journal_volume
63pub_type
杂志文章abstract：:Examination of the adult os coxae and sacrum is one of the most common methods of sex estimation from bone. Medical imaging, such as computed tomography (CT), provides the opportunity for three-dimensional (3D) imaging of the skeleton from clinical scans of known individuals in situ. In this study, a randomly selected...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01803.x
更新日期：2011-09-01 00:00:00
abstract：:Hunting gazelle is an offense according to Israeli law. When comparative isoelectric focusing was performed on bloodstains made from gazelle, goat, sheep, and cow blood, the pattern obtained from gazelle hemoglobin differed from those of the other animals tested. The use of this difference in hemoglobin pattern is sug...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
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更新日期：1989-03-01 00:00:00
abstract：:The "physical strength hypothesis" (PSH) predicts that where there is the greatest discrepancy in size and strength between offenders and victims, the former will use superior weaponry (e.g., firearms) to overcome structural imbalances against the latter. Using archival data from the New York Times and the Chicago Tri...
journal_title：Journal of forensic sciences
pub_type： 历史文章,杂志文章
doi：10.1111/j.1556-4029.2009.01210.x
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：:Deoxyribonucleic acid (DNA) samples extracted from stained pap smear, semen smear and postcoital slides were amplified by the polymerase chain reaction (PCR) and typed for the AmpliType PM and HLA DQ alpha alleles. HLA DQ alpha and PM types consistent with blood controls from the donors were obtained. Stained cells fi...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:The contribution of a physical anthropologist to a forensic investigation is generally associated with analysis of skeletal remains in a laboratory. This case, which deals with the identification of two U.S. journalists who disappeared in Guatemala in March 1985, shows that the observations of a physical anthropologis...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1993-11-01 00:00:00
abstract：:Electrokinetic injection (EI) is the primary method used in forensic laboratories to load amplified PCR product in capillary electrophoresis for short tandem repeat (STR) fragment separation. Because all samples subjected to capillary electrophoresis use internal lane standard (ILS), this study investigated the conseq...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12945
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12001
更新日期：2013-01-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2012.02108.x
更新日期：2012-07-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-07-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2003-07-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12771
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01702.x
更新日期：2011-05-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:The 1970s have yielded many situations in which psychiatrists have been summoned by agents of the state for help in resolving terrorist-related crises. This paper tries to examine the evolving role of forensic psychiatrists as they participate in such situations and reviews some of the functions involved in open commu...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13505
更新日期：2018-01-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2002-07-01 00:00:00
abstract：:Age estimation methods are often based on the age-related morphological changes of the auricular surface and the pubic bone. In this study, a mathematical approach to quantify these changes has been tested analyzing the curvature variation on 3D models from CT and laser scans. The sample consisted of the 24 Suchey-Bro...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12689
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1996-05-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/j.1556-4029.2011.01818.x
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
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journal_title：Journal of forensic sciences
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.12922
更新日期：2016-01-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
abstract：:Inks from seven black and eight blue ballpoint pens were separated by a high-performance liquid chromatography (HPLC) method utilizing a photodiode array detection (PDA). A classifier flowchart was designed for the chromatographic data based on the presence or absence of certain peaks at different wavelengths to quali...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：2000-07-01 00:00:00
abstract：:Two hundred and twenty-eight consecutive medicolegal autopsies were studied as to the cause of death established by a physician, the mode of death as suggested in the police report, and findings of medical interest often discovered following autopsy. Corrections had to be made even in some cases which seemed to be obv...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1988-03-01 00:00:00
abstract：:A portable capillary electrophoresis instrument with dual capacitively coupled contactless conductivity detection (C4 D) was used to determine the inorganic ionic profiles of three pharmaceutical samples and precursors of two illicit drugs (contemporary samples of methylone and para-methoxymethamphetamine). The LODs r...
journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：10.1111/1556-4029.13175
更新日期：2016-11-01 00:00:00
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journal_title：Journal of forensic sciences
pub_type： 杂志文章
doi：
更新日期：1975-07-01 00:00:00
