Abstract:
OBJECTIVE:Comorbidities add to the burden of disease and its complexity, and may prevent the achievement of treat-to-target goals. The objective of this study was to study the relationship between comorbidities and key disease outcomes in spondyloarthritis (SpA), namely function, work ability, and quality of life. METHODS:Patients from the multinational (22 countries), cross-sectional Assessment in SpondyloArthritis international Society (ASAS) Comorbidities in Spondyloarthritis study were included in the analysis, provided they fulfilled the ASAS criteria. Data on comorbidities based on both self- and physician-report were collected through questionnaires and were subsequently used to compute the Rheumatic Disease Comorbidity Index (RDCI). Univariable and multivariable (adjusted for relevant confounders) multilevel (with country as a random effect) linear or logistic (as appropriate) regression analyses were conducted to investigate the relationship between the RDCI and functional ability, work ability, and quality of life. RESULTS:In total, 3,370 of 3,984 recruited patients (85%) fulfilled the ASAS criteria: 66% were male, mean ± SD age was 43 ± 14 years, mean ± SD disease duration was 8.4 ± 9.5 years, and mean ± SD RDCI was 0.7 ± 1.1. At least 1 comorbidity was reported in 51% of patients; 9% had ≥3 comorbidities. RDCI was independently associated with a higher Bath Ankylosing Spondylitis Functional Index score (β = 0.37, 95% confidence interval [95% CI] 0.30, 0.43), lower EuroQol 5-domain questionnaire (β = -0.03, 95% CI -0.04, -0.02), less work employment (odds ratio [OR] 0.83, 95% CI 0.76, 0.91), higher absenteeism (OR 1.18, 95% CI 1.04, 1.34), and higher presenteeism (OR 1.42, 95% CI 1.26, 1.61). CONCLUSION:Comorbidities in SpA adversely influence physical function, work ability, and quality of life and are important to take into account in daily clinical practice.
journal_name
Arthritis Care Res (Hoboken)journal_title
Arthritis care & researchauthors
Nikiphorou E,Ramiro S,van der Heijde D,Norton S,Moltó A,Dougados M,van den Bosch F,Landewé R,Assessment of SpondyloArthritis International Society Comorbidities in Spondyloarthritis Study Task Force.doi
10.1002/acr.23468subject
Has Abstractpub_date
2018-08-01 00:00:00pages
1257-1262issue
8eissn
2151-464Xissn
2151-4658journal_volume
70pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To determine the clinical manifestations and disease damage associated with discoid rash in a large multiethnic systemic lupus erythematosus (SLE) cohort. METHODS:SLE patients (per American College of Rheumatology [ACR] criteria) ages ≥16 years with a disease duration of ≤10 years at enrollment and defined e...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21581
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:We examined quality measures for screening, diagnosis, and treatment of lupus nephritis (LN) among participants of the California Lupus Epidemiology Study across 25 different clinical sites to identify gaps in quality of care. METHODS:Data from 250 participants with lupus were analyzed across 3 sources (medi...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23915
更新日期:2020-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.21970
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:Low-dose aspirin may reduce the risk of developing rheumatoid arthritis (RA) through its effect on cyclooxygenase activity and its antioxidant pathways. Previous randomized trial data have demonstrated a beneficial effect of low-dose aspirin in reducing other inflammatory diseases, such as asthma and colorect...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20042
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To compare the quality of care received by patients with systemic lupus erythematosus (SLE) in 2 settings within the academic institution (a dedicated lupus clinic and a general rheumatology clinic) using validated SLE quality measures. METHODS:One hundred fifty consenting, consecutive SLE patients receiving...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Since 2014, rheumatology fellows have been assessed not only based on their ability to provide patient care and possess medical knowledge but also on their skill in serving as patient advocates, navigators of health systems, and members of a health care team. Such assessments have been carried out through the...
journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-11-12 00:00:00
abstract:OBJECTIVE:To evaluate if exercise programs in trials for patients with ankylosing spondylitis (AS) have the potential for effectiveness. METHODS:A systematic literature search was performed and randomized trials examining the effectiveness of exercise programs for AS patients were analyzed according to 3 elements: whe...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20415
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:The influence of specific medications on the risk of postoperative infection in patients with rheumatoid arthritis and other inflammatory rheumatic diseases (IRDs) remains unclear. This retrospective study examined the risk of postoperative infection at the site of surgery in patients treated with immunosuppr...
journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22077
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To determine the extent to which thigh intermuscular fat (IMF) and quadriceps muscle (QM) volumes explained variance in knee extensor strength and physical performance in women with radiographic knee osteoarthritis (ROA) and without. METHODS:Baseline data from 125 women (age ≥50 years) in the Osteoarthritis ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.21868
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between biochemical markers involved in bone turnover and bone features on imaging in knees with osteoarthritis (OA). METHODS:We analyzed data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative (n = 600). Bone ...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
abstract:OBJECTIVE:The hepatitis B virus (HBV) testing rates and patterns in rheumatoid arthritis (RA) patients starting disease-modifying antirheumatic drugs (DMARDs) have not been well studied. We describe and compare the practice patterns of HBV testing among RA patients in the US and Taiwan. METHODS:We conducted a retrospe...
journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.23241
更新日期:2018-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,meta分析
doi:10.1002/acr.24097
更新日期:2020-12-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22542
更新日期:2015-07-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.23613
更新日期:2019-02-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究
doi:10.1002/acr.22667
更新日期:2016-03-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22306
更新日期:2014-09-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/acr.23255
更新日期:2017-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.22845
更新日期:2016-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2020-04-27 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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journal_title:Arthritis care & research
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Arthritis care & research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2016-04-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
doi:10.1002/acr.20548
更新日期:2011-10-01 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章,随机对照试验
doi:10.1002/acr.21699
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-07-03 00:00:00
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journal_title:Arthritis care & research
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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更新日期:2012-04-01 00:00:00