Abstract：
:Serotonergic (5-HT) neuronal pathways regulate the release of adrenocorticotropin hormone (ACTH) from the pituitary gland probably through the action of hypothalamic corticotropin-releasing hormone (CRH). 8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a selective 5-HT1A receptor agonist, dose dependently (0.016-3 mg/kg s.c.) increased rat plasma ACTH concentration. This response was blocked stereoselectively by (-)-pindolol, known to have 5-HT1 antagonist properties, but not by (+)-pindolol, beta 1-, beta 2- or alpha 1-adrenoceptor, dopamine, muscarinic, 5-HT2 or 5-HT3 receptor antagonists. Similar increases of plasma ACTH were induced by other 5-HT1A receptor ligands (buspirone, ipsapirone and gepirone). These results suggest that activation of the 5-HT1A receptor induces the secretion of ACTH from the rat pituitary gland.
journal_name
Eur J Pharmacoljournal_title
European journal of pharmacologyauthors
Gilbert F,Brazell C,Tricklebank MD,Stahl SMdoi
10.1016/0014-2999(88)90178-1subject
Has Abstractpub_date
1988-03-15 00:00:00pages
431-9issue
3eissn
0014-2999issn
1879-0712pii
0014-2999(88)90178-1journal_volume
147pub_type
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