Abstract:
:Recent findings suggest an association between obesity, loss of gut barrier function and changes in microbiota profiles. Our primary objective was to examine the effect of caloric restriction and subsequent weight reduction on gut permeability in obese women. The impact on inflammatory markers and fecal microbiota was also investigated. The 4-week very-low calorie diet (VLCD, 800 kcal/day) induced a mean weight loss of 6.9 ± 1.9 kg accompanied by a reduction in HOMA-IR (Homeostasis model assessment-insulin resistance), fasting plasma glucose and insulin, plasma leptin, and leptin gene expression in subcutaneous adipose tissue. Plasma high-molecular weight adiponectin (HMW adiponectin) was significantly increased after VLCD. Plasma levels of high-sensitivity C-reactive protein (hsCRP) and lipopolysaccharide-binding protein (LBP) were significantly decreased after 28 days of VLCD. Using three different methods, gut paracellular permeability was decreased after VLCD. These changes in clinical parameters were not associated with major consistent changes in dominant bacterial communities in feces. In summary, a 4-week caloric restriction resulted in significant weight loss, improved gut barrier integrity and reduced systemic inflammation in obese women.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Ott B,Skurk T,Hastreiter L,Lagkouvardos I,Fischer S,Büttner J,Kellerer T,Clavel T,Rychlik M,Haller D,Hauner Hdoi
10.1038/s41598-017-12109-9subject
Has Abstractpub_date
2017-09-20 00:00:00pages
11955issue
1issn
2045-2322pii
10.1038/s41598-017-12109-9journal_volume
7pub_type
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